INT11183

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Context Info
Confidence 0.34
First Reported 1992
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 6.99
Pain Relevance 2.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SH2B2) signal transduction (SH2B2) plasma membrane (SH2B2)
cytoplasm (SH2B2) signal transducer activity (SH2B2)
Anatomy Link Frequency
neurons 1
hearts 1
SH2B2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Action potential 4 100.00 Very High Very High Very High
interstitial cystitis 11 98.92 Very High Very High Very High
aspirin 32 98.34 Very High Very High Very High
qutenza 8 94.76 High High
Demyelination 6 88.20 High High
tetrodotoxin 1 87.84 High High
Central nervous system 13 82.08 Quite High
dorsal root ganglion 1 71.44 Quite High
imagery 27 68.76 Quite High
Pain 5 64.72 Quite High
Disease Link Frequency Relevance Heat
Anti-phospholipid Antibody Syndrome 261 100.00 Very High Very High Very High
Recurrence 17 100.00 Very High Very High Very High
Neurological Disease 6 100.00 Very High Very High Very High
Syndrome 97 99.96 Very High Very High Very High
Psychosis 10 99.04 Very High Very High Very High
Interstitial Cystitis 11 98.92 Very High Very High Very High
Autoimmune Disease 18 98.04 Very High Very High Very High
Hemorrhage 5 97.92 Very High Very High Very High
Thrombophilia 158 97.64 Very High Very High Very High
Thrombosis Related Under Development 138 96.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
High-intensity anticoagulation is recommended as a standard for preventing thrombotic recurrences in APS with a lower intensity in patients at high risk of bleeding or at low risk of severe thrombosis.205,209-211

CONCLUSION

Negative_regulation (preventing) of APS associated with anti-phospholipid antibody syndrome, hemorrhage, thrombosis related under development and recurrence
1) Confidence 0.34 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628175 Disease Relevance 2.07 Pain Relevance 0.16
Apamin, a bee venom polypeptide, was reported to block the naturally occurring Ca2+ slow action potentials (APs) in cultured cell reaggregates from old chick hearts [Bkaily, G. et al.
Negative_regulation (block) of APs in hearts associated with action potential
2) Confidence 0.27 Published 1992 Journal Am. J. Physiol. Section Abstract Doc Link 1539705 Disease Relevance 0 Pain Relevance 0.14
Other neurological disorders in APS
Negative_regulation (disorders) of APS associated with neurological disease and anti-phospholipid antibody syndrome
3) Confidence 0.25 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628175 Disease Relevance 2.12 Pain Relevance 0.12
The number of APs was increased 4.5 fold in FIC neurons.
Negative_regulation (number) of APs in neurons associated with interstitial cystitis
4) Confidence 0.04 Published 2005 Journal Exp. Neurol. Section Abstract Doc Link 15869946 Disease Relevance 1.01 Pain Relevance 1.60
The combination of aspirin and heparin or low molecular weight (LMW) heparin is effective in recurrent fetal loss in APS syndrome and could be considered for women with inherited thrombophilias and history of severe preeclampsia, IUGR, abruptio placentae or fetal loss, although no controlled studies on the subject are currently available.
Negative_regulation (loss) of APS associated with aspirin, thrombophilia, syndrome, abruptio placentae, anti-phospholipid antibody syndrome and pre-eclampsia
5) Confidence 0.03 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC305329 Disease Relevance 1.80 Pain Relevance 0.10

General Comments

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