INT111858

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Context Info
Confidence 0.41
First Reported 2003
Last Reported 2010
Negated 0
Speculated 4
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.75
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Rock1) cytoskeleton (Rock1) cytoskeleton organization (Rock1)
cytoplasm (Rock1)
Anatomy Link Frequency
nucleus accumbens 2
synapses 1
Rock1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
amygdala 294 98.44 Very High Very High Very High
Dopamine 28 96.76 Very High Very High Very High
Nucleus accumbens 22 96.12 Very High Very High Very High
long-term potentiation 26 87.20 High High
Glutamate 6 58.96 Quite High
Morphine 8 25.00 Low Low
tetrodotoxin 6 25.00 Low Low
opioid receptor 2 25.00 Low Low
agonist 2 25.00 Low Low
antagonist 12 7.76 Low Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 152 99.52 Very High Very High Very High
Shock 40 5.00 Very Low Very Low Very Low
Overdose 4 5.00 Very Low Very Low Very Low
Aids-related Complex 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study was designed to investigate the role of the Rho/Rho-associated kinase (ROCK)-dependent pathway in the expression of the increase in extracellular levels of dopamine in the nucleus accumbens and its related behaviors induced by methamphetamine in rats.
Spec (investigate) Regulation (role) of Rho-associated kinase in nucleus accumbens associated with nucleus accumbens and dopamine
1) Confidence 0.41 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12871568 Disease Relevance 0 Pain Relevance 0.27
The present study was designed to investigate the role of the Rho/Rho-associated kinase (ROCK)-dependent pathway in the expression of the increase in extracellular levels of dopamine in the nucleus accumbens and its related behaviors induced by methamphetamine in rats.
Spec (investigate) Regulation (role) of ROCK in nucleus accumbens associated with nucleus accumbens and dopamine
2) Confidence 0.41 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12871568 Disease Relevance 0 Pain Relevance 0.27
Additional studies will be required to determine whether auditory fear conditioning similarly regulates Rho/ROCK signaling at presynaptic sites in the LA, and whether this is driven by NO-cGMP-PKG signaling.
Spec (whether) Regulation (regulates) of Rho/ROCK associated with anxiety disorder and amygdala
3) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0.50 Pain Relevance 0.24
In this final series of experiments, we examined the involvement of the Rho/ROCK and CaMKII signaling pathways in regulating these pre- and postsynaptic modifications at LA synapses.
Spec (examined) Regulation (involvement) of Rho/ROCK in synapses associated with amygdala
4) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0.25 Pain Relevance 0.30

General Comments

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