INT111859

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Context Info
Confidence 0.61
First Reported 2003
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.23
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Rhoa) mitochondrion (Rhoa) cell morphogenesis (Rhoa)
intracellular (Rhoa) GTPase activity (Rhoa) cytoplasm (Rhoa)
Anatomy Link Frequency
nucleus accumbens 1
smooth muscle 1
Rhoa (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Serotonin 2 99.84 Very High Very High Very High
Spinal cord 66 99.72 Very High Very High Very High
Nucleus accumbens 11 99.68 Very High Very High Very High
Dopamine 14 87.68 High High
opioid receptor 1 74.40 Quite High
agonist 1 73.12 Quite High
fluoxetine 2 73.04 Quite High
Morphine 4 72.48 Quite High
tetrodotoxin 3 64.32 Quite High
Central nervous system 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Spinal Cord Injury 33 89.44 High High
Death 10 88.28 High High
Apoptosis 28 5.00 Very Low Very Low Very Low
Injury 5 5.00 Very Low Very Low Very Low
Infection 4 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low
Obesity 2 5.00 Very Low Very Low Very Low
Adenovirus Infection 2 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low
Demyelinating Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we analyze the mechanisms of RhoA regulation by serotonin (5-HT) in arterial smooth muscle. 5-HT (0.1-10 microM) induced activation of RhoA followed by RhoA depletion at 24-72 h.
Regulation (regulation) of RhoA in smooth muscle associated with serotonin
1) Confidence 0.61 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17142836 Disease Relevance 0 Pain Relevance 0.21
Under these conditions, there were no changes in protein levels of membrane-bound RhoA in the nucleus accumbens following methamphetamine treatment.
Neg (no) Regulation (changes) of RhoA in nucleus accumbens associated with nucleus accumbens
2) Confidence 0.47 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12871568 Disease Relevance 0 Pain Relevance 0.89
Down regulation of RhoA activity alone did not enhance survival of transplanted cells in our experiments.
Regulation (regulation) of RhoA
3) Confidence 0.29 Published 2009 Journal Mol Brain Section Body Doc Link PMC2789715 Disease Relevance 0.23 Pain Relevance 0.12

General Comments

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