INT111869

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Context Info
Confidence 0.64
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.63
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (AVP) cell-cell signaling (AVP) response to stress (AVP)
signal transducer activity (AVP) cytosol (AVP) extracellular space (AVP)
AVP (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 12 100.00 Very High Very High Very High
Enkephalin 1 100.00 Very High Very High Very High
substance P 3 99.68 Very High Very High Very High
alcohol 1 94.52 High High
depression 4 65.76 Quite High
antagonist 20 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
beta blocker 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyponatremia 64 84.52 Quite High
Autism 9 79.12 Quite High
Neurological Disease 3 78.40 Quite High
Stress 1 78.32 Quite High
Depression 4 65.76 Quite High
Manic Depressive Disorder 4 64.80 Quite High
Schizophrenia 4 64.00 Quite High
Syndrome 7 56.80 Quite High
Volume Depletion And Dehydration 3 46.56 Quite Low
Congenital Anomalies 1 39.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, PEP also degrades many active hormones/neuropeptides, e.g. oxytocin, arginine vasopressin (AVP), substance P, neurotensin, luteinizing hormone-releasing hormone (LH-RH) and thyrotropin-releasing hormone (TRH) [2].
Protein_catabolism (degrades) of arginine vasopressin associated with neuropeptide and substance p
1) Confidence 0.64 Published 2005 Journal BMC Psychiatry Section Body Doc Link PMC1190193 Disease Relevance 0.55 Pain Relevance 0.27
During transport, pro-vasopressin is enzymatically cleaved into AVP, neurophysin, and a C-terminal glycopeptide.
Protein_catabolism (cleaved) of vasopressin
2) Confidence 0.53 Published 2010 Journal Core evidence Section Body Doc Link PMC2899773 Disease Relevance 0.08 Pain Relevance 0
Of a range of peptides tested, only vasopressin, oxytocin, and met-enkephalin were rapidly cleaved by IRAP.
Protein_catabolism (cleaved) of vasopressin associated with enkephalin
3) Confidence 0.04 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12871575 Disease Relevance 0 Pain Relevance 0.15

General Comments

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