INT111886

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Context Info
Confidence 0.69
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0.91
Pain Relevance 1.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Dnm2) cytoskeleton (Dnm2) nucleus (Dnm2)
GTPase activity (Dnm2) protein complex (Dnm2) cytoplasm (Dnm2)
Anatomy Link Frequency
spinal cord 2
Dnm2 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 9 99.60 Very High Very High Very High
Potency 2 99.42 Very High Very High Very High
agonist 2 99.26 Very High Very High Very High
Opioid 5 98.24 Very High Very High Very High
antagonist 4 97.96 Very High Very High Very High
MU agonist 4 90.32 High High
opioid receptor 1 88.16 High High
Immobilon 5 86.80 High High
analgesia 1 79.60 Quite High
mu opioid receptor 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Convulsion 68 86.44 High High
Ataxia 14 84.52 Quite High
Epilepsy 30 77.32 Quite High
Paralysis 2 73.28 Quite High
Cancer 2 56.88 Quite High
Stroke 2 56.12 Quite High
Brain Injury 2 55.80 Quite High
Hearing Impairment 8 42.40 Quite Low
Ganglion Cysts 2 33.00 Quite Low
Sprains And Strains 12 15.28 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dnm2 is expressed in all tissues [11].
Gene_expression (expressed) of Dnm2
1) Confidence 0.69 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2916854 Disease Relevance 0.80 Pain Relevance 0
This particular alternative exon pair of Dnm1 and Dnm2 is conserved in all vertebrates including mice (e.g.
Gene_expression (pair) of Dnm2
2) Confidence 0.60 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2916854 Disease Relevance 0.11 Pain Relevance 0
Analysis of these results indicated a significant correlation between muOR down-regulation and DYN-2 abundance in mouse spinal cord.
Gene_expression (abundance) of DYN-2 in spinal cord associated with spinal cord
3) Confidence 0.58 Published 2005 Journal Synapse Section Abstract Doc Link 15765525 Disease Relevance 0 Pain Relevance 0.86
Therefore, this study examined muOR density, agonist potency, and the abundance and gene expression of GRK-2, DYN-2, and G(ialpha2) in mouse spinal cord after opioid antagonist treatment.
Gene_expression (expression) of DYN-2 in spinal cord associated with antagonist, agonist, opioid, spinal cord and potency
4) Confidence 0.55 Published 2003 Journal Synapse Section Abstract Doc Link 12872295 Disease Relevance 0 Pain Relevance 0.79

General Comments

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