INT111903

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Context Info
Confidence 0.61
First Reported 2003
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 9
Total Number 13
Disease Relevance 3.95
Pain Relevance 7.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Mmp2) cytoplasm (Mmp2) extracellular space (Mmp2)
peptidase activity (Mmp2) extracellular region (Mmp2) proteinaceous extracellular matrix (Mmp2)
Anatomy Link Frequency
lungs 2
hippocampus 2
Mmp2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 546 100.00 Very High Very High Very High
intrathecal 2 100.00 Very High Very High Very High
antidepressant 54 99.90 Very High Very High Very High
Inflammation 96 99.68 Very High Very High Very High
Hippocampus 40 97.52 Very High Very High Very High
IPN 1 97.04 Very High Very High Very High
fibrosis 160 96.84 Very High Very High Very High
cytokine 28 95.16 Very High Very High Very High
Desipramine 6 92.92 High High
fluoxetine 6 91.56 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 92 99.68 Very High Very High Very High
Nociception 1 99.68 Very High Very High Very High
Pulmonary Fibrosis 112 97.24 Very High Very High Very High
Inflammatory Pain 1 97.04 Very High Very High Very High
Hypoxia 78 95.24 Very High Very High Very High
Convulsion 8 92.16 High High
Neurodegenerative Disease 12 90.96 High High
Disease 8 90.64 High High
Edema 20 90.08 High High
Fibrosis 92 87.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, zymography studies addressed the regulation of the gelatinase activity of MMP-2/9 following acute and chronic antidepressant administration.
Regulation (regulation) of gelatinase associated with antidepressant
1) Confidence 0.61 Published 2008 Journal Synapse Section Abstract Doc Link 18509851 Disease Relevance 0.16 Pain Relevance 0.76
We observed that acute and chronic ECS differentially regulate the transcript levels of MMP-2/9 and TIMPs 1-4 and also increase gelatinase activity in the hippocampus.
Regulation (regulate) of MMP-2 in hippocampus associated with hippocampus
2) Confidence 0.61 Published 2008 Journal Synapse Section Abstract Doc Link 18509851 Disease Relevance 0.15 Pain Relevance 0.80
The change of MMP-2 was not as profound as MMP-9, nevertheless, still showed a similar pattern, reaching the maximum on the 4th day and decreasing thereafter.
Regulation (change) of MMP-2 associated with metalloproteinase
3) Confidence 0.49 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2649867 Disease Relevance 0.11 Pain Relevance 0.63
Antidepressant treatments regulate matrix metalloproteinases-2 and -9 (MMP-2/MMP-9) and tissue inhibitors of the metalloproteinases (TIMPS 1-4) in the adult rat hippocampus.
Regulation (regulate) of MMP-2 in hippocampus associated with antidepressant, metalloproteinase and hippocampus
4) Confidence 0.45 Published 2008 Journal Synapse Section Title Doc Link 18509851 Disease Relevance 0.16 Pain Relevance 0.64
In the present study, the authors examined the effect of intrathecal injection of MMP-2 on the nociceptive transmission during the rat formalin test (a model of inflammatory pain).
Spec (examined) Regulation (effect) of MMP-2 associated with nociception, ipn and intrathecal
5) Confidence 0.38 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12873732 Disease Relevance 0.20 Pain Relevance 0.43
In our study, the levels of the MMP-2 and MMP-9 in the lung parenchyma corresponded well to those of BAL fluid.
Regulation (corresponded) of MMP-2 in lung associated with metalloproteinase
6) Confidence 0.36 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2649867 Disease Relevance 0.58 Pain Relevance 1.08
From the 7th day, there were fewer inflammatory cells, and the intensity of the MMP-2 and MMP-9 staining was weakened.
Regulation (intensity) of MMP-2 associated with inflammation and metalloproteinase
7) Confidence 0.36 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2649867 Disease Relevance 0.51 Pain Relevance 0.66
Given the hippocampal structural remodeling associated with antidepressant treatments, we hypothesized that antidepressants may regulate the expression and activity of MMP-2/9 and TIMPs 1-4.
Spec (may) Regulation (regulate) of MMP-2 associated with antidepressant
8) Confidence 0.27 Published 2008 Journal Synapse Section Abstract Doc Link 18509851 Disease Relevance 0.17 Pain Relevance 0.70
Acute and chronic pharmacological antidepressants on the other hand differentially alter the expression of the TIMPs without any observed effect on hippocampal MMP-2/9 expression or activity.
Neg (without) Regulation (effect) of MMP-2 associated with antidepressant
9) Confidence 0.27 Published 2008 Journal Synapse Section Abstract Doc Link 18509851 Disease Relevance 0.12 Pain Relevance 0.73
In addition, zymography studies addressed the regulation of the gelatinase activity of MMP-2/9 following acute and chronic antidepressant administration.
Regulation (regulation) of MMP-2 associated with antidepressant
10) Confidence 0.27 Published 2008 Journal Synapse Section Abstract Doc Link 18509851 Disease Relevance 0.16 Pain Relevance 0.76
In contrast, previous data from our laboratory demonstrated the up regulation of MMP-9 and/or MMP-2 levels in the brain [15] and lungs [42] as early as 2.5 h post-resuscitation, with a good correlation between MMP levels and in situ zymography activity in the lungs.
Regulation (regulation) of MMP-2 in lungs
11) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000320 Disease Relevance 0.22 Pain Relevance 0.03
0.002 and p<0.001 for the 21%, 40% and 100% groups), suggesting an up regulation of the MMP activity, particularly the gelatinases MMP-2 and/or MMP-9.
Regulation (up regulat) of MMP-2
12) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000320 Disease Relevance 0.61 Pain Relevance 0.09
In this study, we tried to investigate the changes in the level of MMP-2 and MMP-9 and their various cellular sources in different stages of pulmonary fibrosis by estimating the changes of the activity of those MMPs at different time intervals in bleomycin-induced pulmonary fibrosis in rats.


Spec (investigate) Regulation (changes) of MMP-2 associated with fibrosis, metalloproteinase and pulmonary fibrosis
13) Confidence 0.09 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2649867 Disease Relevance 0.80 Pain Relevance 0.65

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