INT111943

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.46
First Reported 2003
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.33
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (RAC1) cell motility (RAC1) cell adhesion (RAC1)
plasma membrane (RAC1) enzyme binding (RAC1) GTPase activity (RAC1)
Anatomy Link Frequency
MCF7 2
RAC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 8 98.52 Very High Very High Very High
agonist 2 75.80 Quite High
MU agonist 1 72.08 Quite High
opioid receptor 1 70.24 Quite High
opiate 1 54.32 Quite High
depression 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Glutamate receptor 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Malignant Neoplastic Disease 9 98.84 Very High Very High Very High
Breast Cancer 53 93.96 High High
Adhesions 2 86.40 High High
Apoptosis 11 81.28 Quite High
Death 2 48.16 Quite Low
Cancer 25 5.00 Very Low Very Low Very Low
Metastasis 4 5.00 Very Low Very Low Very Low
Reprotox - General 3 2 5.00 Very Low Very Low Very Low
Hyperplasia 1 5.00 Very Low Very Low Very Low
Repression 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment of MCF7 cells with the specific PI-3 kinase inhibitor wortmannin abolished both the activation of Rac1 and actin reorganization, while the opioid-induced phosphorylation of FAK and vinculin remained unaffected.
Negative_regulation (abolished) of Positive_regulation (activation) of Rac1 in MCF7 associated with malignant neoplastic disease and opioid
1) Confidence 0.46 Published 2003 Journal Exp. Cell Res. Section Abstract Doc Link 12878162 Disease Relevance 0.68 Pain Relevance 0.78
The resveratrol-mediated induction of p21WAF1 was blocked by treatment with the pure anti-oestrogen ICI 182,780, confirming p21WAF1 gene regulation as an ER-mediated event.


Negative_regulation (blocked) of Positive_regulation (induction) of p21WAF1
2) Confidence 0.01 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400678 Disease Relevance 0.65 Pain Relevance 0.07

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox