INT111944

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Context Info
Confidence 0.73
First Reported 2003
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 6
Disease Relevance 5.23
Pain Relevance 1.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (VCL) extracellular region (VCL) cell adhesion (VCL)
structural molecule activity (VCL) plasma membrane (VCL) cytoskeleton (VCL)
Anatomy Link Frequency
MCF7 2
epithelial cells 1
VCL (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 16 99.84 Very High Very High Very High
peptic ulcer disease 4 91.60 High High
MU agonist 2 87.00 High High
opioid receptor 2 85.16 High High
opiate 2 61.28 Quite High
Disease Link Frequency Relevance Heat
Adhesions 18 100.00 Very High Very High Very High
Ulcers 12 99.92 Very High Very High Very High
Malignant Neoplastic Disease 16 99.24 Very High Very High Very High
Injury 4 96.60 Very High Very High Very High
Disease 12 96.56 Very High Very High Very High
Alagille Syndrome 4 96.28 Very High Very High Very High
Stomach Cancer 4 90.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The Helicobacter pylori CagA protein disrupts matrix adhesion of gastric epithelial cells by dephosphorylation of vinculin.
Phosphorylation (dephosphorylation) of vinculin in epithelial cells associated with ulcers and adhesions
1) Confidence 0.73 Published 2007 Journal Cell. Microbiol. Section Title Doc Link 17217431 Disease Relevance 1.01 Pain Relevance 0.09
Tyrosine dephosphorylation of vinculin results in severe cellular deficiencies in cell-matrix adhesion, cell spreading and wound repair.
Phosphorylation (dephosphorylation) of vinculin associated with injury and adhesions
2) Confidence 0.73 Published 2007 Journal Cell. Microbiol. Section Abstract Doc Link 17217431 Disease Relevance 0.94 Pain Relevance 0.07
Vinculin dephosphorylation disturbs the interaction and recruitment of the actin-related protein 2/3 (Arp2/3) complex by p34Arc, resulting in a reduction of focal adhesion complexes.
Phosphorylation (dephosphorylation) of Vinculin associated with adhesions
3) Confidence 0.73 Published 2007 Journal Cell. Microbiol. Section Abstract Doc Link 17217431 Disease Relevance 0.97 Pain Relevance 0.08
Owing to the inactivation of c-Src via CagA interaction, vinculin is dephosphorylated at tyrosine residues, 100 and 1065, by corresponding phosphatases.
Phosphorylation (dephosphorylated) of vinculin
4) Confidence 0.73 Published 2007 Journal Cell. Microbiol. Section Abstract Doc Link 17217431 Disease Relevance 0.97 Pain Relevance 0.09
Pretreatment of MCF7 cells with the specific PI-3 kinase inhibitor wortmannin abolished both the activation of Rac1 and actin reorganization, while the opioid-induced phosphorylation of FAK and vinculin remained unaffected.
Phosphorylation (phosphorylation) of vinculin in MCF7 associated with malignant neoplastic disease and opioid
5) Confidence 0.50 Published 2003 Journal Exp. Cell Res. Section Abstract Doc Link 12878162 Disease Relevance 0.66 Pain Relevance 0.80
Immunoprecipitation and immunoblot analyses showed rapid phosphorylation of focal adhesion kinase (FAK) and vinculin in opioid-treated MCF7 cells.
Phosphorylation (phosphorylation) of vinculin in MCF7 associated with malignant neoplastic disease, opioid and adhesions
6) Confidence 0.50 Published 2003 Journal Exp. Cell Res. Section Abstract Doc Link 12878162 Disease Relevance 0.68 Pain Relevance 0.59

General Comments

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