INT111947

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Context Info
Confidence 0.68
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.75
Pain Relevance 4.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grin2a) plasma membrane (Grin2a) locomotion (Grin2a)
Anatomy Link Frequency
neurons 4
NAc 2
PAG 2
cortex 2
Grin2a (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 346 100.00 Very High Very High Very High
Central grey 2 99.84 Very High Very High Very High
tolerance 14 99.70 Very High Very High Very High
Morphine 16 99.38 Very High Very High Very High
withdrawal 2 99.22 Very High Very High Very High
Nucleus accumbens 10 99.12 Very High Very High Very High
Ventral tegmentum 6 98.48 Very High Very High Very High
addiction 11 97.48 Very High Very High Very High
amygdala 3 95.84 Very High Very High Very High
Physical dependence 6 95.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 35 99.84 Very High Very High Very High
Drug Dependence 6 95.56 Very High Very High Very High
Aging 228 91.68 High High
Depression 87 90.68 High High
Nociception 2 90.60 High High
Cognitive Disorder 50 61.88 Quite High
Targeted Disruption 22 40.84 Quite Low
Sprains And Strains 16 36.16 Quite Low
Disease 19 30.40 Quite Low
Anxiety Disorder 4 14.72 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GluRepsilon1-/- mice showed marked loss of typical withdrawal abstinence behaviors, and significant enhancement of GluRepsilon1 protein expression was only observed in NAc by chronic morphine treatments after dependence paradigm.
Positive_regulation (enhancement) of Gene_expression (expression) of GluRepsilon1 protein in NAc associated with addiction, nucleus accumbens, withdrawal and morphine
1) Confidence 0.68 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12878694 Disease Relevance 0.41 Pain Relevance 2.08
In C57BL/6J mice treated with chronic morphine after tolerance paradigm, the GluRepsilon1 protein expression significantly increased in periaqueductal gray matter (PAG), ventral tegmental area (VTA) and nucleus accumbens (NAc), but not amygdala or hippocampus.
Neg (not) Positive_regulation (increased) of Gene_expression (expression) of GluRepsilon1 protein in PAG associated with ventral tegmentum, central grey, morphine, nucleus accumbens, tolerance, hippocampus, urological neuroanatomy and amygdala
2) Confidence 0.68 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12878694 Disease Relevance 0.51 Pain Relevance 2.00
Viral-mediated overexpression of NR2A or RNAi knockdown of NR2B in the visual cortex specifically during the period of MD may be able to test this by preventing a decrease in the NR2A/B ratio.
Positive_regulation (overexpression) of Gene_expression (overexpression) of NR2A in cortex
3) Confidence 0.45 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2674473 Disease Relevance 0.24 Pain Relevance 0.22
This suggests that enhancing the expression of the NR2A subunit in aged individuals may be beneficial in light of the declines seen in the other subunits with age.
Positive_regulation (enhancing) of Gene_expression (expression) of NR2A subunit
4) Confidence 0.38 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874396 Disease Relevance 0.40 Pain Relevance 0.09
Furthermore, several lines of evidence suggest that the enhanced NMDA currents in cultured neurons are not caused by an enhanced expression of NR2A and/or NR2B subunits.
Positive_regulation (enhanced) of Gene_expression (expression) of NR2A in neurons
5) Confidence 0.35 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0 Pain Relevance 0.07
These data suggest that NMDA receptors with both types of NR2 subunits are present on these EGFP+ lamina II neurons.
Positive_regulation (present) of Gene_expression (receptors) of NR2 in neurons associated with nmda receptor
6) Confidence 0.30 Published 2010 Journal Mol Pain Section Body Doc Link PMC2879240 Disease Relevance 0 Pain Relevance 0.29
Two subunits have been discovered in the GluN3 family, GluN3A and GluN3B subunits (Ciabarra et al., 1995; Sucher et al., 1995; Nishi et al., 2001; Chatterton et al., 2002).
Positive_regulation (discovered) of Gene_expression (discovered) of GluN3A
7) Confidence 0.27 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874396 Disease Relevance 0.18 Pain Relevance 0.10

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