INT111958

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Context Info
Confidence 0.16
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.34
Pain Relevance 1.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
vein 1
Thim (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 7 98.84 Very High Very High Very High
hypoalgesia 5 98.84 Very High Very High Very High
Chronic pancreatitis 96 98.08 Very High Very High Very High
Morphine 2 97.20 Very High Very High Very High
Pain 9 93.56 High High
Central grey 27 92.76 High High
Neuronal excitability 1 83.44 Quite High
Neurotransmitter 1 82.20 Quite High
iatrogenic 1 78.80 Quite High
Hippocampus 9 76.88 Quite High
Disease Link Frequency Relevance Heat
Pancreatic Cancer 16 99.56 Very High Very High Very High
Hypoalagesia 5 98.84 Very High Very High Very High
Nicotine Addiction 3 98.40 Very High Very High Very High
Ovarian Hyperstimulation Syndrome 3 98.20 Very High Very High Very High
Pancreatitis 123 98.08 Very High Very High Very High
Thrombosis 6 97.28 Very High Very High Very High
Pain 11 93.56 High High
Urological Neuroanatomy 27 92.76 High High
Sepsis 1 91.12 High High
Stress 1 85.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed we observed such an effect in THIM-treated rats in the form of hypoalgesia and amplified sensitivity to morphine [11].
Regulation (effect) of THIM associated with hypoalgesia and morphine
1) Confidence 0.16 Published 2010 Journal Neurochem Res Section Body Doc Link PMC2957583 Disease Relevance 0.56 Pain Relevance 0.82
Additionally, phenotype-genotype associations will be confirmed in offspring from multiple pairs of G3 mice, effectively eliminating the chance of an occurrence of co-homozygosity for an off-target mutation in all G4 target-mutation homozygotes.
Regulation (target) of mutation
2) Confidence 0.01 Published 2005 Journal BMC Genomics Section Body Doc Link PMC1325271 Disease Relevance 0 Pain Relevance 0
We report the case of a 30-year-old woman heterozygous for both the prothrombin 3' UTR mutation and for the factor V Leiden mutation who presented with a proximal deep vein thrombosis following in vitro fertilization.
Regulation (heterozygous) of mutation in vein associated with thrombosis
3) Confidence 0.00 Published 2003 Journal Am. J. Hematol. Section Abstract Doc Link 12879433 Disease Relevance 1.04 Pain Relevance 0.10
However, affected mutation carriers should be strongly advised to stop smoking, as it is an additional risk factor for pancreatic cancer [34].


Regulation (affected) of mutation associated with nicotine addiction and pancreatic cancer
4) Confidence 0.00 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 1.74 Pain Relevance 0.75

General Comments

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