INT111960

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Context Info
Confidence 0.37
First Reported 2003
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 2.03
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Sod2) oxidoreductase activity (Sod2) mitochondrion organization (Sod2)
DNA binding (Sod2) response to stress (Sod2) cytoplasm (Sod2)
Sod2 (Mus musculus)
Pain Link Frequency Relevance Heat
Angina 4 98.76 Very High Very High Very High
spinal inflammation 1 75.00 Quite High
tolerance 1 71.76 Quite High
imagery 9 57.16 Quite High
Glutamate 2 54.80 Quite High
Central nervous system 8 54.72 Quite High
cytokine 3 47.04 Quite Low
Inflammation 28 18.08 Low Low
Eae 5 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 7 99.08 Very High Very High Very High
Cv General 3 Under Development 4 98.76 Very High Very High Very High
Hyperglycemia 55 97.98 Very High Very High Very High
Stress 49 93.20 High High
Death 8 89.04 High High
Cancer 77 79.76 Quite High
Low Back Pain 1 75.00 Quite High
Neuropathic Pain 1 74.16 Quite High
Disease 10 69.84 Quite High
Targeted Disruption 72 62.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
During hyperglycemia, excess glucose levels induce over-production of ROS in the mitochondria, which subsequently causes depletion of SOD2 and leads to cellular injury [2], [8]–[10].
SOD2 Binding (depletion) of associated with hyperglycemia and injury
1) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956689 Disease Relevance 1.36 Pain Relevance 0.08
SOD2 activity in knockdown lysates was determined by comparing with an SOD2 standard curve (SOD2 enzyme; Sigma) and expressed relative to that in the wild-type lysates.


SOD2 Spec (determined) Binding (comparing) of
2) Confidence 0.32 Published 2006 Journal PLoS Genet Section Body Doc Link PMC1358942 Disease Relevance 0.22 Pain Relevance 0.04
This might be due to the interaction between MnSOD and p53, which leads to inactivation of MnSOD activity, as previous studies have demonstrated [36].
MnSOD Spec (might) Binding (interaction) of
3) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2668769 Disease Relevance 0 Pain Relevance 0.03
MnSOD and total SOD activity assays
MnSOD Binding (activity) of
4) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2668769 Disease Relevance 0.08 Pain Relevance 0
Association of the manganese superoxide dismutase polymorphism with vasospastic angina pectoris.
manganese superoxide dismutase Binding (Association) of associated with angina
5) Confidence 0.06 Published 2010 Journal J Cardiol Section Title Doc Link 20206073 Disease Relevance 0.29 Pain Relevance 0.37
OBJECTIVES: To investigate the associations of cytochrome p450 1A1 (CYP1A1) and manganese superoxide dismutase (MnSOD) genes polymorphisms with the susceptibility to AS in Taiwan.
manganese superoxide dismutase Binding (associations) of
6) Confidence 0.04 Published 2003 Journal Immunol. Lett. Section Abstract Doc Link 12880680 Disease Relevance 0.07 Pain Relevance 0.07

General Comments

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