INT11197

Context Info Confidence 0.06 First Reported 1992 Last Reported 1992 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.20 Pain Relevance 0.14

signal transduction (Gnat3) GTPase activity (Gnat3) cytoplasm (Gnat3) signal transducer activity (Gnat3)

Anatomy Link Frequency heart 2 Gnat3 (Mus musculus)

Pain Link Frequency Relevance Heat Angina 1 98.00 tolerance 1 87.92

Disease Link Frequency Relevance Heat Cv General 3 Under Development 1 98.00 Heart Rate Under Development 1 97.20

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Metabolism of nitroglycerin (GTN) in the vascular smooth muscle is required for the drug to be effective in the treatment of angina pectoris and congestive heart failure.

Positive_regulation (required) of Negative_regulation (Metabolism) of GTN in heart associated with heart rate under development and angina

1) Confidence 0.06 Published 1992 Journal Biochem. Pharmacol. Section Abstract Doc Link 1540213 Disease Relevance 0.20 Pain Relevance 0.14

General Comments

This test has worked.