INT11198

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Context Info
Confidence 0.59
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.49
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gclc) ligase activity (Gclc)
Anatomy Link Frequency
smooth muscle cells 1
Gclc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 10 91.88 High High
tolerance 2 69.32 Quite High
Angina 1 65.52 Quite High
methotrexate 1 52.64 Quite High
Bioavailability 2 49.12 Quite Low
Multiple sclerosis 4 47.96 Quite Low
gABA 18 5.00 Very Low Very Low Very Low
Dopamine 14 5.00 Very Low Very Low Very Low
Glutamate 8 5.00 Very Low Very Low Very Low
depression 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 6 78.64 Quite High
Mitochondrial Disorders 5 76.36 Quite High
Cerebellar Diseases 9 67.16 Quite High
Heart Rate Under Development 1 66.68 Quite High
Cv General 3 Under Development 1 65.52 Quite High
Miller Fisher Syndrome 2 62.32 Quite High
Demyelinating Disease 5 47.96 Quite Low
Ataxia 73 44.28 Quite Low
Neurodegenerative Disease 5 37.28 Quite Low
Enteropathy 1 36.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Buthionine sulfoximine selectively inhibits gamma-glutamylcysteine synthetase, thereby preventing cysteine utilization for glutathione resynthesis.
Negative_regulation (inhibits) of gamma-glutamylcysteine synthetase
1) Confidence 0.59 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3941389 Disease Relevance 0 Pain Relevance 0.74
Gamma-glutamylcysteine synthetase is inhibited by feedback from GSH (Ki around 1, 5 mM).
Negative_regulation (inhibited) of Gamma-glutamylcysteine synthetase
2) Confidence 0.09 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2866461 Disease Relevance 0.35 Pain Relevance 0.03
Pretreatment with buthionine sulfoximine, inhibitor of gamma-glutamylcysteine synthetase, decreased intracellular glutathione and caused decreased GTN metabolism in smooth muscle cells.
Negative_regulation (inhibitor) of gamma-glutamylcysteine synthetase in smooth muscle cells
3) Confidence 0.06 Published 1992 Journal Biochem. Pharmacol. Section Abstract Doc Link 1540213 Disease Relevance 0.13 Pain Relevance 0.10

General Comments

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