INT111993

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.22
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 5.02
Pain Relevance 2.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Acta2) cytoplasm (Acta2)
Anatomy Link Frequency
PSCs 18
smooth muscle 6
Acta2 (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 35 98.00 Very High Very High Very High
COX-2 inhibitor 3 96.96 Very High Very High Very High
cytokine 15 95.64 Very High Very High Very High
fibrosis 22 94.96 High High
alcohol 4 90.20 High High
Inflammatory response 3 82.68 Quite High
Inflammation 2 68.80 Quite High
Kinase C 1 50.00 Quite Low
COX2 3 25.00 Low Low
anesthesia 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Primary Sclerosing Cholangitis 26 100.00 Very High Very High Very High
Pancreatitis 38 98.00 Very High Very High Very High
Fibrosis 29 94.96 High High
Injury 10 91.36 High High
Hyperlipidemia 4 82.92 Quite High
INFLAMMATION 5 82.28 Quite High
Disease 5 80.32 Quite High
Stress 4 75.00 Quite High
Keloid Scars 2 69.36 Quite High
Necrosis 4 68.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of mRNA for collagen alpha1(I), alpha-smooth muscle actin or CTGF were all increased and co-localized exclusively to activated PSC in ACP.
Positive_regulation (increased) of Gene_expression (Expression) of alpha-smooth muscle actin in PSC associated with primary sclerosing cholangitis and chronic pancreatitis
1) Confidence 0.22 Published 2010 Journal Lab. Invest. Section Abstract Doc Link 20368699 Disease Relevance 1.32 Pain Relevance 0.72
In mice receiving ethanol plus cerulein, there was increased collagen deposition as compared with other treatment groups as well as increased frequency of alpha-smooth muscle actin and desmin-positive PSC, which also showed significantly enhanced CTGF protein production.
Positive_regulation (enhanced) of Gene_expression (production) of alpha-smooth muscle actin in PSC associated with primary sclerosing cholangitis
2) Confidence 0.19 Published 2010 Journal Lab. Invest. Section Abstract Doc Link 20368699 Disease Relevance 1.31 Pain Relevance 0.71
Whether the increased expression of alpha smooth muscle actin is related to the tumorgenic nature of Huh-7 cells has to be determined.
Positive_regulation (increased) of Gene_expression (expression) of alpha smooth muscle actin in smooth muscle
3) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722022 Disease Relevance 0 Pain Relevance 0
Engrafted MSC in liver express alpha smooth muscle actin and their localization merges with collagen deposition
Positive_regulation (Engrafted) of Gene_expression (express) of alpha smooth muscle actin in smooth muscle
4) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722022 Disease Relevance 0.09 Pain Relevance 0.05
In addition, alpha-SMA expression was up-regulated significantly (p < 0.05).
Positive_regulation (up-regulated) of Gene_expression (expression) of alpha-SMA
5) Confidence 0.01 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16814251 Disease Relevance 0.69 Pain Relevance 0.05
In animal experiment, alpha-SMA expression was detected 7 days after the ligation and was increased on the 10th day.
Positive_regulation (increased) of Gene_expression (expression) of alpha-SMA
6) Confidence 0.01 Published 2003 Journal J. Surg. Res. Section Body Doc Link 13678692 Disease Relevance 0 Pain Relevance 0
Adenovirus-mediated expression of dominant negative Smad2/3 inhibited the increase in expression of COX-2, alpha-SMA, and collagen-1 mediated by TGF-beta1 in activated PSCs.
Positive_regulation (increase) of Gene_expression (expression) of alpha-SMA in PSCs
7) Confidence 0.01 Published 2007 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 16837651 Disease Relevance 0.42 Pain Relevance 0.29
TGF-beta1, IL-1beta, and IL-6 enhanced COX-2 expression in activated PSCs, concomitantly increasing the expression of alpha-smooth muscle actin (alpha-SMA), a parameter of PSC activation.
Positive_regulation (increasing) of Gene_expression (expression) of alpha-SMA in smooth muscle associated with primary sclerosing cholangitis
8) Confidence 0.00 Published 2007 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 16837651 Disease Relevance 0.43 Pain Relevance 0.34
Anti-TGF-beta neutralizing antibody also attenuated the increase in COX-2 and alpha-SMA expression caused by IL-1beta and IL-6.
Positive_regulation (increase) of Gene_expression (expression) of alpha-SMA
9) Confidence 0.00 Published 2007 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 16837651 Disease Relevance 0.34 Pain Relevance 0.22
Treatment of PSCs with SB203580 abolished the ethanol- and acetaldehyde-induced increase in p38 MAPK activity and also prevented the induction of alpha-SMA expression in PSCs.
Positive_regulation (induction) of Gene_expression (expression) of alpha-SMA in PSCs
10) Confidence 0.00 Published 2003 Journal Pancreas Section Body Doc Link 12883264 Disease Relevance 0 Pain Relevance 0
RESULTS: High glucose concentrations significantly increased PSC proliferation, alpha-SMA expression, and collagen type I production in PSCs.
Positive_regulation (increased) of Gene_expression (expression) of alpha-SMA in PSCs
11) Confidence 0.00 Published 2007 Journal Pancreas Section Body Doc Link 17414061 Disease Relevance 0.16 Pain Relevance 0
Treatment of PSC with TGF-beta1 decreased proliferation, had no significant effect on migration and MMP expression, but increased expression and synthesis of procollagen alpha2(I) and alpha-SMA.
Neg (no) Positive_regulation (increased) of Gene_expression (expression) of alpha-SMA in PSC
12) Confidence 0.00 Published 2005 Journal Pancreas Section Body Doc Link 16025003 Disease Relevance 0 Pain Relevance 0
Application of pressure significantly increased BrdU incorporation and alpha-SMA expression.
Positive_regulation (increased) of Gene_expression (expression) of alpha-SMA
13) Confidence 0.00 Published 2004 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15319186 Disease Relevance 0.13 Pain Relevance 0.18
CONCLUSIONS: (1) The MAP kinase pathway is induced in PSCs after exposure to ethanol or acetaldehyde and this induction is sustained for at least 24h. (2) The p38 MAPK pathway mediates the activation (as indicated by increased alpha-SMA expression) of PSCs by ethanol or acetaldehyde.


Positive_regulation (increased) of Gene_expression (expression) of alpha-SMA in PSCs
14) Confidence 0.00 Published 2003 Journal Pancreas Section Body Doc Link 12883264 Disease Relevance 0 Pain Relevance 0
However, inhibition of ERK 1/2 and JNK had no effect on ethanoland acetaldehyde-induced alpha-SMA expression in PSCs.
Positive_regulation (induced) of Gene_expression (expression) of alpha-SMA in PSCs
15) Confidence 0.00 Published 2003 Journal Pancreas Section Body Doc Link 12883264 Disease Relevance 0 Pain Relevance 0
AIMS: To examine the effects of ethanol and acetaldehyde on the MAPK pathway (by assessing the activities of the 3 major subfamilies (extracellular-regulated kinases 1 and 2 [ERK 1/2], JNK and p38 kinase) in PSCs and to examine the role of p38 kinase in mediating the ethanol- and acetaldehyde-induced increase in alpha-SMA expression in activated rat PSCs.
Positive_regulation (increase) of Gene_expression (expression) of alpha-SMA in PSCs
16) Confidence 0.00 Published 2003 Journal Pancreas Section Body Doc Link 12883264 Disease Relevance 0 Pain Relevance 0
However, at the protein level, PDGF-BB impairs typical TGF-beta1 effects such as increased synthesis of collagen (type I) and alpha-SMA.
Positive_regulation (increased) of Gene_expression (synthesis) of alpha-SMA
17) Confidence 0.00 Published 2005 Journal Pancreas Section Body Doc Link 16025003 Disease Relevance 0 Pain Relevance 0
Application of pressure significantly increased BrdU incorporation and alpha-SMA expression.
Positive_regulation (incorporation) of Gene_expression (expression) of alpha-SMA
18) Confidence 0.00 Published 2004 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15319186 Disease Relevance 0.12 Pain Relevance 0.18

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox