INT112

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Context Info
Confidence 0.74
First Reported 1976
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 0.18
Pain Relevance 3.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Pdia3) endoplasmic reticulum (Pdia3)
Anatomy Link Frequency
liver 1
brainstem 1
thalamus 1
reticulum 1
Pdia3 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 58 100.00 Very High Very High Very High
methadone 8 95.56 Very High Very High Very High
tolerance 3 79.04 Quite High
Face pain 2 50.00 Quite Low
Central nervous system 33 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Spinal cord 3 5.00 Very Low Very Low Very Low
Intracerebroventricular 2 5.00 Very Low Very Low Very Low
allodynia 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 2 89.56 High High
Leukemia 3 50.00 Quite Low
Facial Pain 2 50.00 Quite Low
Necrosis 2 49.24 Quite Low
Infection 62 5.00 Very Low Very Low Very Low
Stress 40 5.00 Very Low Very Low Very Low
Disease 8 5.00 Very Low Very Low Very Low
Targeted Disruption 7 5.00 Very Low Very Low Very Low
Eclampsia 6 5.00 Very Low Very Low Very Low
INFLAMMATION 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Exposure to heme or arsenite induced the synthesis of a protein of similar molecular weight but did not result in the inhibition of p58 biosynthesis.
Gene_expression (biosynthesis) of p58
1) Confidence 0.74 Published 1992 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 1539164 Disease Relevance 0 Pain Relevance 0.61
The fact that the reactive metabolites of both APAP and 3,5-DMA, but not 2,6-DMA, possess oxidative properties suggests that the alterations in the synthesis of p32 and p58 may be related to an oxidative component induced by these compounds.
Gene_expression (synthesis) of p58 associated with paracetamol
2) Confidence 0.74 Published 1992 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 1539164 Disease Relevance 0 Pain Relevance 0.52
Here, we present genetic and functional evidence that another gene with a fundamental role in MHC class I presentation, endoplasmic reticulum aminopeptidase 2 (ERAP2), has also evolved under balancing selection and contains a variant that affects antigen presentation.
Gene_expression (presentation) of endoplasmic reticulum in reticulum
3) Confidence 0.65 Published 2010 Journal PLoS Genetics Section Abstract Doc Link PMC2954825 Disease Relevance 0 Pain Relevance 0
These studies indicate that, although the 58-kDa proteins appear to be endogenous to both target and nontarget tissues, the 58-kDa APAP-protein adducts are detectable only in tissues which become damaged by APAP.
Gene_expression (detectable) of 58-kDa associated with paracetamol
4) Confidence 0.65 Published 1989 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 2734789 Disease Relevance 0 Pain Relevance 0.61
Purification, antibody production, and partial amino acid sequence of the 58-kDa acetaminophen-binding liver proteins.
Gene_expression (production) of 58-kDa in liver associated with paracetamol
5) Confidence 0.65 Published 1992 Journal Toxicol. Appl. Pharmacol. Section Title Doc Link 1553752 Disease Relevance 0 Pain Relevance 0.53
First was a progressive diminution in the de novo synthesis of a protein migrating at approximately 58 kDa (p58).
Gene_expression (synthesis) of p58
6) Confidence 0.64 Published 1992 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 1539164 Disease Relevance 0 Pain Relevance 0.93
Grp58/ERp57: F-TCAAGGGTTTTCCTACCATCTACTTC,
Gene_expression (/) of Grp58
7) Confidence 0.30 Published 2006 Journal Retrovirology Section Body Doc Link PMC1475625 Disease Relevance 0 Pain Relevance 0
Cytochrome P-450 content, when expressed per milligram of microsomal protein, was elevated as early as day 1 of administration.
Gene_expression (expressed) of microsomal protein
8) Confidence 0.09 Published 1980 Journal Drug Alcohol Depend Section Abstract Doc Link 6768537 Disease Relevance 0 Pain Relevance 0.46
PtdCho-PLC and ASMase activities were also assayed in the brainstem, thalamus, and somatosensory cortex.
Gene_expression (assayed) of PtdCho-PLC in brainstem
9) Confidence 0.09 Published 2009 Journal J Orofac Pain Section Body Doc Link 19492541 Disease Relevance 0.09 Pain Relevance 0
The Vmax for each substrate, when expressed per mg of microsomal protein, did not change during the last third of gestation.
Gene_expression (expressed) of microsomal protein
10) Confidence 0.04 Published 1976 Journal Drug Metab. Dispos. Section Abstract Doc Link 10140 Disease Relevance 0 Pain Relevance 0.09
PtdCho-PLC and ASMase activities were also assayed in the brainstem, thalamus, and somatosensory cortex.
Gene_expression (assayed) of PtdCho-PLC in thalamus
11) Confidence 0.03 Published 2009 Journal J Orofac Pain Section Body Doc Link 19492541 Disease Relevance 0.09 Pain Relevance 0

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