INT112013

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Context Info
Confidence 0.38
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.57
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ighg1)
Anatomy Link Frequency
CII 2
Ighg1 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 91 99.48 Very High Very High Very High
cINOD 5 97.68 Very High Very High Very High
dexamethasone 5 94.80 High High
methotrexate 5 94.40 High High
Inflammation 62 92.04 High High
Inflammatory response 9 90.28 High High
rheumatoid arthritis 77 84.24 Quite High
tolerance 4 77.68 Quite High
agonist 9 72.16 Quite High
transdermal 7 50.00 Quite Low
Disease Link Frequency Relevance Heat
Pulmonary Eosinophilia 1 99.92 Very High Very High Very High
Arthritis 91 99.48 Very High Very High Very High
Asthma 40 99.48 Very High Very High Very High
Aspergillus Infection 44 97.80 Very High Very High Very High
INFLAMMATION 76 92.92 High High
Hypersensitivity 72 91.84 High High
Sprains And Strains 22 90.88 High High
Immunization 65 88.44 High High
Rheumatoid Arthritis 87 84.24 Quite High
Influenza Virus Infection 35 82.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Administration of indomethacin resulted in suppression of antigen (OVA)-induced arthritis that was associated with inhibition of anti-OVA IgG2a but not IgG1 production.
Negative_regulation (inhibition) of Gene_expression (production) of IgG1 associated with arthritis
1) Confidence 0.38 Published 2003 Journal J Pharm Sci Section Abstract Doc Link 12884258 Disease Relevance 0.33 Pain Relevance 0.38
Administrations of all the drugs used resulted in suppression of antigen (OVA)-induced arthritis in mice which was associated with inhibition of anti-OVA IgG2a but not IgG1 production.
Negative_regulation (inhibition) of Gene_expression (production) of IgG1 associated with arthritis
2) Confidence 0.36 Published 2005 Journal Int J Immunopathol Pharmacol Section Abstract Doc Link 15698518 Disease Relevance 0.62 Pain Relevance 0.57
C57BL/6 mice developed significant systemic IgE and IgG1 levels following allergenic sensitization and challenge with Af, comparable to the responses of Balb/c mice
Negative_regulation (developed) of Gene_expression (levels) of IgG1 associated with aspergillus infection
3) Confidence 0.34 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 0.83 Pain Relevance 0.04
production after IM vaccination is consistent with the heightened Th1-like response indicated by the reduced IgG1/IgG2a ratio in the IM groups, since IFN-?
Negative_regulation (reduced) of Gene_expression (ratio) of IgG1
4) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651574 Disease Relevance 0.16 Pain Relevance 0
VAD reduced serum IgE and IgG1 responses, pulmonary eosinophilia, and the levels of IL-4 and IL-5 in BALF specimen [39].
Negative_regulation (reduced) of Gene_expression (responses) of IgG1 associated with pulmonary eosinophilia
5) Confidence 0.30 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2773769 Disease Relevance 0.28 Pain Relevance 0.05
Furthermore, B7-H4Ig plasmid treatment suppressed the production of total IgG (Figure 5C) and IgG1, IgG2a, and IgG2b autoantibodies to CII (Figure S7).
Negative_regulation (suppressed) of Gene_expression (production) of IgG1 in CII
6) Confidence 0.29 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 0.67 Pain Relevance 0.30
They also reported that the two bacteria significantly decrease serum levels of OVA-specific IgE/IgG1 and prevent asthma before and after OVA sensitization, which is not in accordance with our results.
Negative_regulation (decrease) of Gene_expression (specific) of IgG1 associated with asthma
7) Confidence 0.29 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2892053 Disease Relevance 0.68 Pain Relevance 0.08

General Comments

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