INT112015

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Context Info
Confidence 0.33
First Reported 2003
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.48
Pain Relevance 2.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hand1) nucleoplasm (Hand1) enzyme binding (Hand1)
DNA binding (Hand1) cytoplasm (Hand1) nucleolus (Hand1)
Hand1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 84 100.00 Very High Very High Very High
cINOD 4 99.40 Very High Very High Very High
Multiple sclerosis 122 99.30 Very High Very High Very High
Transcranial magnetic stimulation 1 99.04 Very High Very High Very High
Demyelination 6 93.92 High High
Inflammation 69 92.92 High High
imagery 47 92.16 High High
rheumatoid arthritis 19 89.32 High High
Enkephalin 3 87.40 High High
Arthritis 13 85.04 High High
Disease Link Frequency Relevance Heat
Multiple Sclerosis 224 99.30 Very High Very High Very High
INFLAMMATION 80 98.68 Very High Very High Very High
Targeted Disruption 14 97.84 Very High Very High Very High
Handedness 18 94.64 High High
Demyelinating Disease 8 93.92 High High
Hypersensitivity 17 91.24 High High
Arthritis 8 91.24 High High
Inflammatory Bowel Disease 2 89.60 High High
Rheumatoid Arthritis 19 89.32 High High
Disease 117 86.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indomethacin inhibited both Th1 and Th2 responses, although the nonsteroidal anti-inflammatory drug suppressed the former more effectively than the latter.
Negative_regulation (inhibited) of Regulation (responses) of Th1 associated with inflammation and cinod
1) Confidence 0.33 Published 2003 Journal J Pharm Sci Section Abstract Doc Link 12884258 Disease Relevance 0.33 Pain Relevance 0.37
We found a clear reduction in Th1 response (IL-2 and IFN-?)
Spec (clear) Negative_regulation (reduction) of Regulation (response) of Th1
2) Confidence 0.25 Published 2005 Journal Respir Res Section Body Doc Link PMC555575 Disease Relevance 0.79 Pain Relevance 0.25
While there are clearly some differences in human and murine systems, therapies for MS have nevertheless aimed to either reduce Th1 or Th17 responses or to increase Th2 responses.
Negative_regulation (reduce) of Regulation (responses) of Th1 associated with multiple sclerosis
3) Confidence 0.21 Published 2011 Journal Biol Sex Differ Section Body Doc Link PMC3022636 Disease Relevance 1.42 Pain Relevance 0.67
Since the underlying mechanisms by which this and other immunomodulatory effects occur have not been established, this report explores the in vitro modulation of Th1 and Th2 cytokine expression by these peptides.
Negative_regulation (explores) of Regulation (modulation) of Th1 associated with cytokine
4) Confidence 0.16 Published 2005 Journal Neuroimmunomodulation Section Abstract Doc Link 16557034 Disease Relevance 0.09 Pain Relevance 0.34
It was suggested that the therapeutic mechanism of this recombinant protein was through induction of Treg cell development and IL-10 expression with the subsequent suppression of Th1 and Th17 responses [46].
Negative_regulation (suppression) of Regulation (responses) of Th1
5) Confidence 0.07 Published 2011 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2963117 Disease Relevance 0.75 Pain Relevance 0.29
More precisely, a transcranial magnetic stimulation (TMS) study has demonstrated that the cortical control (in the contralateral hemisphere) of the left hand is more impaired than that of the right hand with advancing age [46].
Negative_regulation (impaired) of Regulation (control) of hand associated with transcranial magnetic stimulation
6) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2726952 Disease Relevance 0.09 Pain Relevance 0.13

General Comments

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