INT112015

Context Info Confidence 0.33 First Reported 2003 Last Reported 2011 Negated 0 Speculated 1 Reported most in Body Documents 5 Total Number 6 Disease Relevance 3.48 Pain Relevance 2.05

cell differentiation (Hand1) nucleoplasm (Hand1) enzyme binding (Hand1) DNA binding (Hand1) cytoplasm (Hand1) nucleolus (Hand1)

Hand1 (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 84 100.00 cINOD 4 99.40 Multiple sclerosis 122 99.30 Transcranial magnetic stimulation 1 99.04 Demyelination 6 93.92 Inflammation 69 92.92 imagery 47 92.16 rheumatoid arthritis 19 89.32 Enkephalin 3 87.40 Arthritis 13 85.04

Disease Link Frequency Relevance Heat Multiple Sclerosis 224 99.30 INFLAMMATION 80 98.68 Targeted Disruption 14 97.84 Handedness 18 94.64 Demyelinating Disease 8 93.92 Hypersensitivity 17 91.24 Arthritis 8 91.24 Inflammatory Bowel Disease 2 89.60 Rheumatoid Arthritis 19 89.32 Disease 117 86.36

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Indomethacin inhibited both Th1 and Th2 responses, although the nonsteroidal anti-inflammatory drug suppressed the former more effectively than the latter.

Negative_regulation (inhibited) of Regulation (responses) of Th1 associated with inflammation and cinod

1) Confidence 0.33 Published 2003 Journal J Pharm Sci Section Abstract Doc Link 12884258 Disease Relevance 0.33 Pain Relevance 0.37

We found a clear reduction in Th1 response (IL-2 and IFN-?)

Spec (clear) Negative_regulation (reduction) of Regulation (response) of Th1

2) Confidence 0.25 Published 2005 Journal Respir Res Section Body Doc Link PMC555575 Disease Relevance 0.79 Pain Relevance 0.25

While there are clearly some differences in human and murine systems, therapies for MS have nevertheless aimed to either reduce Th1 or Th17 responses or to increase Th2 responses.

Negative_regulation (reduce) of Regulation (responses) of Th1 associated with multiple sclerosis

3) Confidence 0.21 Published 2011 Journal Biol Sex Differ Section Body Doc Link PMC3022636 Disease Relevance 1.42 Pain Relevance 0.67

Since the underlying mechanisms by which this and other immunomodulatory effects occur have not been established, this report explores the in vitro modulation of Th1 and Th2 cytokine expression by these peptides.

Negative_regulation (explores) of Regulation (modulation) of Th1 associated with cytokine

4) Confidence 0.16 Published 2005 Journal Neuroimmunomodulation Section Abstract Doc Link 16557034 Disease Relevance 0.09 Pain Relevance 0.34

It was suggested that the therapeutic mechanism of this recombinant protein was through induction of Treg cell development and IL-10 expression with the subsequent suppression of Th1 and Th17 responses [46].

Negative_regulation (suppression) of Regulation (responses) of Th1

5) Confidence 0.07 Published 2011 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2963117 Disease Relevance 0.75 Pain Relevance 0.29

More precisely, a transcranial magnetic stimulation (TMS) study has demonstrated that the cortical control (in the contralateral hemisphere) of the left hand is more impaired than that of the right hand with advancing age [46].

Negative_regulation (impaired) of Regulation (control) of hand associated with transcranial magnetic stimulation

6) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2726952 Disease Relevance 0.09 Pain Relevance 0.13

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