INT112017

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Context Info
Confidence 0.36
First Reported 2003
Last Reported 2011
Negated 1
Speculated 5
Reported most in Body
Documents 77
Total Number 82
Disease Relevance 62.23
Pain Relevance 18.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hand2) nucleus (Hand2) DNA binding (Hand2)
protein complex (Hand2) transcription factor binding (Hand2)
Anatomy Link Frequency
T cell 9
lymphocytes 3
immune system 3
Th2 cells 3
dendritic cells 2
Hand2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 2044 100.00 Very High Very High Very High
cINOD 32 100.00 Very High Very High Very High
Multiple sclerosis 430 99.84 Very High Very High Very High
Inflammation 1828 99.72 Very High Very High Very High
Opioid 15 99.60 Very High Very High Very High
chemokine 413 99.28 Very High Very High Very High
antagonist 486 99.24 Very High Very High Very High
tolerance 63 99.24 Very High Very High Very High
Inflammatory response 131 99.16 Very High Very High Very High
Leflunomide 3 98.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1950 100.00 Very High Very High Very High
Demyelinating Disease 356 99.84 Very High Very High Very High
Asthma 2410 99.68 Very High Very High Very High
Burns 130 99.58 Very High Very High Very High
Immunization 188 99.56 Very High Very High Very High
Hypersensitivity 343 99.46 Very High Very High Very High
Cold Sores 1105 99.24 Very High Very High Very High
Influenza Virus Infection 94 99.14 Very High Very High Very High
Infection 534 99.08 Very High Very High Very High
Autoimmune Disease 259 99.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of the nonsteroidal anti-inflammatory drug indomethacin on Th1 and Th2 immune responses in mice.
Regulation (Effect) of Th2 associated with inflammation and cinod
1) Confidence 0.36 Published 2003 Journal J Pharm Sci Section Title Doc Link 12884258 Disease Relevance 0.33 Pain Relevance 0.35
Indomethacin inhibited both Th1 and Th2 responses, although the nonsteroidal anti-inflammatory drug suppressed the former more effectively than the latter.
Regulation (responses) of Th2 associated with inflammation and cinod
2) Confidence 0.36 Published 2003 Journal J Pharm Sci Section Abstract Doc Link 12884258 Disease Relevance 0.33 Pain Relevance 0.37
The present study was undertaken to study the effect of the nonsteroidal anti-inflammatory drug indomethacin on Th1 and Th2 immune responses.
Regulation (effect) of Th2 associated with inflammation and cinod
3) Confidence 0.36 Published 2003 Journal J Pharm Sci Section Abstract Doc Link 12884258 Disease Relevance 0.17 Pain Relevance 0.23
IL-5 and IL-13 levels in the tissue may also be reduced by a direct effect on Th2 cell cytokine elaboration.
Regulation (effect) of Th2 in Th2 cell associated with cytokine
4) Confidence 0.29 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.34 Pain Relevance 0.36
Then, we studied the results of Th2 cytokines affected by the minimal dose of RA treatment.
Regulation (affected) of Th2 associated with rheumatoid arthritis and cytokine
5) Confidence 0.28 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2773769 Disease Relevance 0.45 Pain Relevance 0.14
Down-regulation of Th2 cytokine genes (Il4, Il10, Il13), as described in our data, has been reported in alloreactive T cells in which tolerance has been induced and immune rejection suppressed (Taylor et al. 2002).
Regulation (regulation) of Th2 in T cells associated with tolerance and cytokine
6) Confidence 0.23 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137099 Disease Relevance 1.01 Pain Relevance 0.53
Amongst host immune responses modulated by ixodid ticks, T cell cytokine polarization to an up-regulated Th2 profile appears to be a common strategy often accompanied by a decrease in Th1 cytokine expression [4].
Regulation (regulated) of Th2 in T cell associated with cytokine
7) Confidence 0.22 Published 2009 Journal Parasit Vectors Section Body Doc Link PMC2764639 Disease Relevance 0.58 Pain Relevance 0.19
A Th2 response was superimposed on the background Th1 response.
Regulation (response) of Th2
8) Confidence 0.22 Published 2009 Journal Parasit Vectors Section Body Doc Link PMC2764639 Disease Relevance 0.28 Pain Relevance 0.17
Molecule(s) have not been identified that are responsible for Th2 polarizing activity in D. andersoni saliva.
Regulation (responsible) of Th2 in saliva
9) Confidence 0.22 Published 2009 Journal Parasit Vectors Section Body Doc Link PMC2764639 Disease Relevance 0 Pain Relevance 0
This effect on Th2 cytokines, via a modulation of Th2 activation, may result from a role of H4R in the Th2 priming capability of dendritic cells [6].
Regulation (effect) of Th2 in dendritic cells associated with cytokine
10) Confidence 0.21 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.32 Pain Relevance 0.41
In addition to investigating the anti-inflammatory effects of H4R antagonism, it was important to assess whether its modulation of Th2 cytokines could have meaningful effects on allergen induced airway structural changes.
Regulation (modulation) of Th2 associated with inflammation and cytokine
11) Confidence 0.21 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.55 Pain Relevance 0.31
Dysregulation of the Th1/Th2 balance can result in autoimmune diseases [143].
Regulation (Dysregulation) of Th2 associated with autoimmune disease
12) Confidence 0.20 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 1.21 Pain Relevance 0.92
On one hand, administration of anti-IL-10 antibody was shown to enhance pneumococcal immunity [51], while others showed this Th2-associated cytokine is critical for MARCO-1 expression and subsequent pneumococcal clearance [50].
Regulation (critical) of Th2-associated associated with cytokine
13) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2828482 Disease Relevance 0.85 Pain Relevance 0.11
This interaction of SOCS5 with the IL-4 receptor is likely to cause the reduction in IL-4-induced activation of STAT6 and thus to regulate Th2 polarization.
Regulation (regulate) of Th2
14) Confidence 0.19 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.91 Pain Relevance 0
Modulation of SOCS3 levels in T cells could be useful in regulating the Th1/Th2 balance for the treatment of autoimmune inflammatory diseases.


Regulation (regulating) of Th2 in T cells associated with inflammation and disease
15) Confidence 0.19 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 1.87 Pain Relevance 0.31
Our findings of an incomplete Th2 response to aeroallergen stimulation in SHIP-1?
Regulation (response) of Th2
16) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994819 Disease Relevance 0.33 Pain Relevance 0.18
The Th1/Th2 balance of the immune response depends on several factors including the nature of the antigen and the adjuvant, the delivery route and the targeted APCs, as suggested by the ratio of IgG1/IgG2a antibody titers (22).
Regulation (depends) of Th2
17) Confidence 0.17 Published 2009 Journal Pharm Res Section Body Doc Link PMC2689355 Disease Relevance 0.59 Pain Relevance 0
It also can regulate the Th1/Th2 cytokine balance [36] and it is now accepted that changes in the balance of Th1/Th2 type cytokines occur during pregnancy in the feto-placental unit.
Regulation (regulate) of Th2 associated with cytokine
18) Confidence 0.16 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2958556 Disease Relevance 0.37 Pain Relevance 0.31
or IL-10 as specific markers of the Th1 and Th2 response respectively.
Regulation (response) of Th2
19) Confidence 0.16 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2918605 Disease Relevance 1.85 Pain Relevance 0.21
To determine whether the cytokine response in the heart after burn was also related to changes in the Th1 and Th2 we analyzed heart tissue for IFN-?
Spec (whether) Regulation (changes) of Th2 in heart associated with burns and cytokine
20) Confidence 0.16 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2918605 Disease Relevance 1.87 Pain Relevance 0.21

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