INT11202

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Context Info
Confidence 0.57
First Reported 1980
Last Reported 2011
Negated 0
Speculated 1
Reported most in Abstract
Documents 8
Total Number 10
Disease Relevance 1.74
Pain Relevance 3.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pfkm) kinase activity (Pfkm) cytoplasm (Pfkm)
Anatomy Link Frequency
liver 2
blood 1
mammary glands 1
endothelial cells 1
muscle 1
Pfkm (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dexamethasone 2 99.36 Very High Very High Very High
Morphine 18 98.80 Very High Very High Very High
Pain 2 97.24 Very High Very High Very High
Desipramine 4 95.56 Very High Very High Very High
narcan 4 94.64 High High
opiate 2 91.20 High High
antagonist 4 90.64 High High
guanethidine 3 90.28 High High
agonist 1 90.24 High High
Opioid 4 86.00 High High
Disease Link Frequency Relevance Heat
Stress 10 99.78 Very High Very High Very High
Necrosis 4 99.08 Very High Very High Very High
Nash(non-alcoholic Steatohepatitis) 8 94.92 High High
Body Weight 8 91.80 High High
Poisoning 2 90.48 High High
Diabetes Mellitus 41 85.68 High High
Insulin Resistance 33 75.20 Quite High
Syndrome 8 69.16 Quite High
Impaired Glucose Tolerance 8 51.20 Quite High
Fatty Liver 1 41.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The stress caused an activation of hexokinase and phosphofructokinase within 2 and 7 days, activity of pyruvate kinase was not altered.
Positive_regulation (activation) of phosphofructokinase associated with stress
1) Confidence 0.57 Published 1985 Journal Vopr. Med. Khim. Section Abstract Doc Link 3157268 Disease Relevance 0.70 Pain Relevance 0.19
Corticotropin increased the activity of PFK in the mammary glands of intact and hypophysectomised animals but was without any effect in tissues from ovariectomised and adrenalectomised animals.
Positive_regulation (increased) of PFK in mammary glands
2) Confidence 0.47 Published 1983 Journal Horm. Res. Section Abstract Doc Link 6301962 Disease Relevance 0 Pain Relevance 0.57
Nalozone treatment alone, to both intact and ovariectomized/adrenalectomized animals, resulted in stimulation of PFK and inhibition of PHI activities.
Positive_regulation (stimulation) of PFK
3) Confidence 0.46 Published 1980 Journal J. Endocrinol. Section Abstract Doc Link 6447740 Disease Relevance 0 Pain Relevance 1.01
It included activation of key glycolytic enzymes: hexokinase, glucokinase and phosphofructokinase and increase blood and liver tissue glucose being increased.
Positive_regulation (increased) of phosphofructokinase in blood
4) Confidence 0.26 Published 2004 Journal Biomed Khim Section Abstract Doc Link 15354538 Disease Relevance 0.18 Pain Relevance 0.26
The constitutive expression and inducibility of UDP-GT isozyme(s) for 1-naphthol glucuronidation was also clearly demonstrated in Kupffer and endothelial cells.
Positive_regulation (inducibility) of isozyme in endothelial cells
5) Confidence 0.11 Published 1992 Journal Biochem. Pharmacol. Section Abstract Doc Link 1540226 Disease Relevance 0 Pain Relevance 0.15
It included activation of key glycolytic enzymes: hexokinase, glucokinase and phosphofructokinase and increase blood and liver tissue glucose being increased.
Positive_regulation (increased) of phosphofructokinase in liver
6) Confidence 0.09 Published 2004 Journal Biomed Khim Section Abstract Doc Link 15354538 Disease Relevance 0.18 Pain Relevance 0.26
Tremblay et al. [38] have shown that 16 weeks of HIIE significantly increased phosphofructokinase levels which is a key rate limiting enzyme in glycolysis, whereas Macdougall et al. [53] also showed increases in phosphofructokinase with a Wingate-type protocol carried out for 7 weeks.
Positive_regulation (increased) of phosphofructokinase
7) Confidence 0.03 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2991639 Disease Relevance 0.15 Pain Relevance 0
Tremblay et al. [38] have shown that 16 weeks of HIIE significantly increased phosphofructokinase levels which is a key rate limiting enzyme in glycolysis, whereas Macdougall et al. [53] also showed increases in phosphofructokinase with a Wingate-type protocol carried out for 7 weeks.
Positive_regulation (increases) of phosphofructokinase
8) Confidence 0.03 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2991639 Disease Relevance 0.21 Pain Relevance 0.03
F affects the partitioning of fatty acids toward their esterification, which has been shown in isolated perfused livers.48,49 In addition, F increases phosphofructokinase mRNA as well as G-6PDH and CHREB50 and fatty acid synthase activities.51 These effects lead to hepatic lipid loading, resulting in NASH (of which an HF diet is a relevant model in rats).
Positive_regulation (increases) of phosphofructokinase mRNA in livers associated with nash(non-alcoholic steatohepatitis)
9) Confidence 0.02 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2910863 Disease Relevance 0.31 Pain Relevance 0
The low doses (0.1 microgram/ml x 3) of MKV, which did not produce any observable increase in tone of the anococcygeus muscle, potentiated the contractile responses to field stimulation, but not the responses to exogenous NA.
Spec (observable) Positive_regulation (increase) of anococcygeus muscle in muscle
10) Confidence 0.01 Published 1995 Journal Toxicon Section Abstract Doc Link 8585083 Disease Relevance 0 Pain Relevance 0.59

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