INT112027

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Context Info
Confidence 0.75
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 58
Total Number 59
Disease Relevance 30.90
Pain Relevance 15.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Pik3r1) protein complex (Pik3r1) cytoplasm (Pik3r1)
cytosol (Pik3r1) signal transduction (Pik3r1) nucleus (Pik3r1)
Anatomy Link Frequency
PAG 3
skeletal muscle 3
external 2
spinal 2
brains 1
Pik3r1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 236 100.00 Very High Very High Very High
Clonidine 78 100.00 Very High Very High Very High
Pain 54 100.00 Very High Very High Very High
Arthritis 859 99.80 Very High Very High Very High
opioid receptor 19 99.70 Very High Very High Very High
Morphine 144 99.46 Very High Very High Very High
Inflammation 507 98.82 Very High Very High Very High
Inflammatory response 100 98.48 Very High Very High Very High
rheumatoid arthritis 200 98.40 Very High Very High Very High
cytokine 406 98.38 Very High Very High Very High
Disease Link Frequency Relevance Heat
Insulin Resistance 48 100.00 Very High Very High Very High
Pain 25 100.00 Very High Very High Very High
Systemic Lupus Erythematosus 16 100.00 Very High Very High Very High
Hypersensitivity 151 99.96 Very High Very High Very High
Apoptosis 106 99.82 Very High Very High Very High
Arthritis 907 99.80 Very High Very High Very High
Atherosclerosis 48 99.72 Very High Very High Very High
Urological Neuroanatomy 15 99.44 Very High Very High Very High
Disease 454 99.34 Very High Very High Very High
Pressure And Volume Under Development 250 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A single s.c. injection of morphine caused a marked increase in the number of PI3Kgamma-IR expressing cells in the PAG.
Gene_expression (expressing) of PI3K in PAG associated with urological neuroanatomy and morphine
1) Confidence 0.75 Published 2004 Journal Neuroscience Section Abstract Doc Link 14980723 Disease Relevance 0.44 Pain Relevance 0.82
In immunohistochemical studies, phosphoinositide 3-kinase (PI3K) was detected in the membrane of the cell soma and the immunoreactivity of PI3K (PI3K-IR) was almost overlapped with MOR-IR and PLC gamma 1-IR in the periaqueductal gray matter (PAG) that is considered to be one of the most important sites for the expression of MOR-mediated antinociception.
Gene_expression (detected) of PI3K in PAG associated with antinociception, urological neuroanatomy, opioid receptor and central grey
2) Confidence 0.73 Published 2003 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 12884752 Disease Relevance 0.19 Pain Relevance 0.97
Double immunolabeling assay showed that MOR-IR was mostly overlapped with PI3Kgamma-IR on the cell surface in the PAG section.
Gene_expression (overlapped) of PI3K in PAG associated with urological neuroanatomy and opioid receptor
3) Confidence 0.65 Published 2004 Journal Neuroscience Section Abstract Doc Link 14980723 Disease Relevance 0.44 Pain Relevance 0.88
Inhibition of peripheral PI3K signaling dose-dependently prevented and reversed pain behaviors and spinal Fos protein expression induced by intraplantar injection of ephrinB1-Fc.
Gene_expression (expression) of PI3K in spinal associated with pain
4) Confidence 0.65 Published 2010 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 20170671 Disease Relevance 0.33 Pain Relevance 0.45
These data demonstrated that PI3K and PI3K crosstalk to ERK signaling mediated pain behaviors induced by activation of peripheral ephrinBs/EphBs signaling in mice.
Gene_expression (crosstalk) of PI3K associated with pain
5) Confidence 0.65 Published 2010 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 20170671 Disease Relevance 0.39 Pain Relevance 0.43
These data demonstrated that PI3K and PI3K crosstalk to ERK signaling mediated pain behaviors induced by activation of peripheral ephrinBs/EphBs signaling in mice.
Gene_expression (crosstalk) of PI3K associated with pain
6) Confidence 0.65 Published 2010 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 20170671 Disease Relevance 0.39 Pain Relevance 0.42
There are two principal findings: (1) intrathecal pretreatment with wortmannin or LY294002, two structurally unrelated PI3K inhibitors, produced a dose-dependent increase of naloxone-precipitated withdrawal jumping, which was accompanied by an increased expression of spinal Fos protein in acute and chronic morphine-dependent mice; and (2) the expression of spinal p110gamma, the catalytic subunit PI3K, in the membrane fraction was significantly down-regulated by naloxone-precipitated withdrawal in acute and chronic morphine-dependent mice.
Gene_expression (expression) of PI3K in spinal associated with narcan, withdrawal, morphine and intrathecal
7) Confidence 0.60 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16806705 Disease Relevance 0 Pain Relevance 0.87
Intraplantar injection of ephrinB1-Fc produced a time- and dose-dependent increase of PI3K-p110gamma expression and of phosphorylation of AKT in skin of injection site.
Gene_expression (expression) of PI3K in skin
8) Confidence 0.58 Published 2010 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 20170671 Disease Relevance 0.33 Pain Relevance 0.37
In skeletal muscle, enhanced PI3K expression or downstream signalling promotes myoblast differentiation [21] and skeletal muscle growth [6], [7] but does not result in transformation of terminally differentiated skeletal muscle [22], [23].
Gene_expression (expression) of PI3K in myoblast
9) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905373 Disease Relevance 0.14 Pain Relevance 0
The PI3K pathway is activated after allergen challenge in sensitized mice and expression of a dominant-negative PI3K subunit or use of PI3K inhibitors ameliorate the inflammatory response to allergen [4], [5], [6].
Gene_expression (expression) of PI3K associated with inflammatory response
10) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994819 Disease Relevance 0.64 Pain Relevance 0.15
Altered PI3K/Akt signaling is also found in the skeletal muscle of young men with low birth weight (Jensen et al. 2008).
Gene_expression (/) of PI3K in skeletal muscle associated with birth weight
11) Confidence 0.36 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920914 Disease Relevance 0.17 Pain Relevance 0.03
Altered PI3K/Akt signaling is also found in the skeletal muscle of young men with low birth weight (Jensen et al. 2008).
Gene_expression (found) of PI3K in skeletal muscle associated with birth weight
12) Confidence 0.36 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920914 Disease Relevance 0.17 Pain Relevance 0.03
As suggested by ontology classifications of individual genes and enrichment of specific gene sets, ephrin receptor signaling and various signaling pathways such as PI3K/AKT and Wnt/?
Gene_expression (pathways) of PI3K
13) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816210 Disease Relevance 0 Pain Relevance 0.18
As suggested by ontology classifications of individual genes and enrichment of specific gene sets, ephrin receptor signaling and various signaling pathways such as PI3K/AKT and Wnt/?
Gene_expression (/) of PI3K
14) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816210 Disease Relevance 0 Pain Relevance 0.18
Phosphatidylinositol 3┬ľkinase inhibitor (PI3K-I), LY294002 (70920; Cayman Chemical, Ann Arbor, MI), was predissolved in DMSO and subsequently diluted in aCSF (final concentration 5% DMSO).
Gene_expression (diluted) of PI3K
15) Confidence 0.33 Published 2010 Journal Diabetes Section Body Doc Link PMC2797943 Disease Relevance 0.09 Pain Relevance 0.07
Injections of insulin (or vehicle aCSF), PI3K-I (or vehicle aCSF with 5% DMSO), or insulin antibodies (I8510; Sigma, St.
Gene_expression (Injections) of PI3K
16) Confidence 0.33 Published 2010 Journal Diabetes Section Body Doc Link PMC2797943 Disease Relevance 0.09 Pain Relevance 0.06
Phosphatidylinositol 3┬ľkinase inhibitor (PI3K-I), LY294002 (70920; Cayman Chemical, Ann Arbor, MI), was predissolved in DMSO and subsequently diluted in aCSF (final concentration 5% DMSO).
Gene_expression (predissolved) of PI3K
17) Confidence 0.33 Published 2010 Journal Diabetes Section Body Doc Link PMC2797943 Disease Relevance 0.09 Pain Relevance 0.07
PI3K/AKT signaling that may also account for the inhibitory action of PPAR?
Gene_expression (/) of PI3K
18) Confidence 0.32 Published 2008 Journal PPAR Research Section Body Doc Link PMC2430014 Disease Relevance 0.63 Pain Relevance 0.05
PI3K/AKT signaling that may also account for the inhibitory action of PPAR?
Gene_expression (signaling) of PI3K
19) Confidence 0.32 Published 2008 Journal PPAR Research Section Body Doc Link PMC2430014 Disease Relevance 0.63 Pain Relevance 0.05
Genes involved in the PI3K signaling pathway were also found to be differentially expressed, and have been shown to be involved in nerve growth cone dynamics [53], neurite growth [54] and synapse function [55].
Gene_expression (expressed) of PI3K in nerve
20) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816210 Disease Relevance 0 Pain Relevance 0.11

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