INT112029

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Context Info
Confidence 0.67
First Reported 2003
Last Reported 2010
Negated 1
Speculated 6
Reported most in Body
Documents 90
Total Number 96
Disease Relevance 38.76
Pain Relevance 20.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Pik3r1) protein complex (Pik3r1) cytoplasm (Pik3r1)
cytosol (Pik3r1) signal transduction (Pik3r1) nucleus (Pik3r1)
Anatomy Link Frequency
muscle 5
PAG 2
skeletal muscle 2
neuronal 2
skin 2
Pik3r1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 538 100.00 Very High Very High Very High
Nerve growth factor 37 100.00 Very High Very High Very High
Clonidine 548 99.98 Very High Very High Very High
Kinase C 1365 99.92 Very High Very High Very High
Paracetamol 26 99.88 Very High Very High Very High
Morphine 97 99.72 Very High Very High Very High
Inflammatory response 131 98.94 Very High Very High Very High
Pyramidal cell 15 98.48 Very High Very High Very High
Delta opioid receptors 3 98.46 Very High Very High Very High
antinociception 16 98.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 696 100.00 Very High Very High Very High
Stress 122 99.88 Very High Very High Very High
Insulin Resistance 211 99.74 Very High Very High Very High
Cancer 995 99.60 Very High Very High Very High
Prostate Cancer 34 99.44 Very High Very High Very High
Starvation 26 99.34 Very High Very High Very High
Neurodegenerative Disease 71 99.18 Very High Very High Very High
Apoptosis 333 99.12 Very High Very High Very High
Urological Neuroanatomy 36 98.76 Very High Very High Very High
Increased Venous Pressure Under Development 300 98.74 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, these results implicate that preassembly of the Pol II preinitiation complex, sustained activation of PI3K/Akt/NF-kappaB signaling, and dynamic p300 association at the promoters sequentially is one of the mechanisms of induction of the late phase genes during NGF-induced neuronal differentiation.
Positive_regulation (activation) of PI3K in neuronal associated with nerve growth factor
1) Confidence 0.67 Published 2010 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 20399742 Disease Relevance 0.05 Pain Relevance 0.48
Collectively, these findings raise the possibility that the activation of the PLC pathway associated with the stimulation of PI3K and/or G beta gamma is implicated in supraspinal antinociception induced by MOR agonists in mice.
Positive_regulation (stimulation) of PI3K associated with antinociception, agonist and opioid receptor
2) Confidence 0.65 Published 2003 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 12884752 Disease Relevance 0.06 Pain Relevance 1.18
Furthermore, upregulation of the PI3K-Akt pathway in mutant mice lacking phosphatase and tensin homolog, a lipid phosphatase counteracting PI3K, selectively enhanced chronic desensitization in a PI3K- and MAPK-dependent manner.
Positive_regulation (upregulation) of PI3K
3) Confidence 0.63 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 14614088 Disease Relevance 0.08 Pain Relevance 0.34
Exogenous NE and clonidine activate PI3Ks
Positive_regulation (activate) of PI3K associated with clonidine
4) Confidence 0.49 Published 2005 Journal BMC Physiol Section Body Doc Link PMC1183225 Disease Relevance 0 Pain Relevance 0.10
These results indicate that NE-elicited phosphorylation of Akt in mesenteric vein requires activation of PI3Ks.
Positive_regulation (activation) of PI3K in mesenteric vein
5) Confidence 0.49 Published 2005 Journal BMC Physiol Section Body Doc Link PMC1183225 Disease Relevance 0 Pain Relevance 0.30
PI3Ks, and particularly PI3K?
Positive_regulation (particularly) of PI3K
6) Confidence 0.49 Published 2005 Journal BMC Physiol Section Body Doc Link PMC1183225 Disease Relevance 0 Pain Relevance 0.42
To determine whether NE directly activates PI3Ks, we measured phosphorylation of Akt in control vein segments and in tissues incubated with exogenous NE (1 ?
Spec (whether) Positive_regulation (activates) of PI3K in vein
7) Confidence 0.49 Published 2005 Journal BMC Physiol Section Body Doc Link PMC1183225 Disease Relevance 0 Pain Relevance 0.15
These observations raise the possibility that the EFS and exogenous NE-induced activation of PI3Ks may be mediated by ?
Positive_regulation (activation) of PI3K
8) Confidence 0.49 Published 2005 Journal BMC Physiol Section Body Doc Link PMC1183225 Disease Relevance 0 Pain Relevance 0.34
Our previous studies have shown that sustained activation of NGF/PI3K/Akt/NF-kappaB signaling is essential for NGF-induced dor gene expression during neuronal differentiation and that the epigenetic modifications at histone 3 lysine 9 temporally correlate with the dor gene transcription.
Positive_regulation (activation) of PI3K in neuronal associated with nerve growth factor
9) Confidence 0.49 Published 2010 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 20399742 Disease Relevance 0.09 Pain Relevance 0.52
These findings suggested that acute treatment with morphine may directly activate the PI3Kgamma/PLCgamma1 pathway in the PAG.
Spec (may) Positive_regulation (activate) of PI3K in PAG associated with urological neuroanatomy and morphine
10) Confidence 0.49 Published 2004 Journal Neuroscience Section Abstract Doc Link 14980723 Disease Relevance 0.44 Pain Relevance 1.03
Intraplantar injection of ephrinB1-Fc produced a time- and dose-dependent increase of PI3K-p110gamma expression and of phosphorylation of AKT in skin of injection site.
Positive_regulation (increase) of PI3K in skin
11) Confidence 0.48 Published 2010 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 20170671 Disease Relevance 0.33 Pain Relevance 0.37
Thus, the activation of PI3Ks, and more specifically PI3K?
Positive_regulation (activation) of PI3K
12) Confidence 0.45 Published 2005 Journal BMC Physiol Section Body Doc Link PMC1183225 Disease Relevance 0 Pain Relevance 0.45
A single s.c. injection of morphine caused a marked increase in the number of PI3Kgamma-IR expressing cells in the PAG.
Positive_regulation (increase) of PI3K in PAG associated with urological neuroanatomy and morphine
13) Confidence 0.45 Published 2004 Journal Neuroscience Section Abstract Doc Link 14980723 Disease Relevance 0.44 Pain Relevance 0.82
Mild Electrical Stimulation with Heat Shock Ameliorates Insulin Resistance via Enhanced Insulin Signaling

Low-intensity electrical current (or mild electrical stimulation; MES) influences signal transduction and activates phosphatidylinositol-3 kinase (PI3K)/Akt pathway.

Positive_regulation (activates) of PI3K associated with shock and insulin resistance
14) Confidence 0.42 Published 2008 Journal PLoS ONE Section Title Doc Link PMC2603588 Disease Relevance 1.13 Pain Relevance 0
Additionally, PA contributes to the activation of Akt/phosphatidylinositol 3-kinase (PI3K) signaling by stimulating PI4P5-kinase [24].
Positive_regulation (activation) of PI3K
15) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 1.13 Pain Relevance 0.10
These results suggest that the CCR9-CCL25 axis mediates PI3K/AKT-dependent antiapoptotic signals in PCa cells and could be a possible reason for low apoptosis and modest chemotherapeutic response.
Positive_regulation (mediates) of PI3K associated with apoptosis and reprotox - general 1
16) Confidence 0.36 Published 2010 Journal Int. J. Cancer Section Abstract Doc Link 20127861 Disease Relevance 0.55 Pain Relevance 0.08
This suggests that growth factor activation of PI3K/PKB plays a limited direct role in the hypertrophy of adult skeletal muscle.



Positive_regulation (activation) of PI3K in skeletal muscle associated with hypertrophy
17) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905373 Disease Relevance 0.23 Pain Relevance 0
However, the enhanced PI3K/PKB signalling following ablation does not lead to significant increases in muscle mass.
Positive_regulation (enhanced) of PI3K in muscle
18) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905373 Disease Relevance 0.23 Pain Relevance 0
While the increase in PI3K/PKB activity in the overloaded PLN muscle did not lead to an increase in muscle growth, it could have led to alterations in phenotype that were not measured.
Positive_regulation (increase) of PI3K in muscle
19) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905373 Disease Relevance 0.37 Pain Relevance 0
Since changing recruitment could lead to greater metabolic stress and therefore greater angiogenesis, this finding is consistent with the hypothesis that the increase in PI3K/PKB activity is important in increasing blood flow to the muscle following overload.
Positive_regulation (increase) of PI3K in muscle associated with stress
20) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905373 Disease Relevance 0.23 Pain Relevance 0

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