INT11203

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Context Info
Confidence 0.75
First Reported 1984
Last Reported 2011
Negated 2
Speculated 0
Reported most in Body
Documents 30
Total Number 30
Disease Relevance 33.49
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (BCR) signal transduction (BCR) plasma membrane (BCR)
kinase activity (BCR)
Anatomy Link Frequency
B-cell 6
lymphocyte 5
PHL 2
ears 2
liver 1
BCR (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 78 96.72 Very High Very High Very High
antidepressant 1 96.44 Very High Very High Very High
fluoxetine 1 95.84 Very High Very High Very High
diclofenac 28 93.36 High High
Pain 33 89.88 High High
imagery 1 85.40 High High
Morphine 2 85.20 High High
Spinal cord 8 78.16 Quite High
Chronic pancreatitis 2 58.24 Quite High
palliative 27 50.88 Quite High
Disease Link Frequency Relevance Heat
Leukemia 917 100.00 Very High Very High Very High
Acute Myeloid Leukemia 80 100.00 Very High Very High Very High
Myeloproliferative Disorder 64 99.96 Very High Very High Very High
Hodgkin's Disease 969 99.88 Very High Very High Very High
Malignant Neoplastic Disease 7 99.70 Very High Very High Very High
Cancer 178 99.60 Very High Very High Very High
Bordatella Infection 3 99.44 Very High Very High Very High
Myeloid Leukemia 44 99.42 Very High Very High Very High
Myelofibrosis 56 99.32 Very High Very High Very High
Hematologic Neoplasms 120 99.26 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At oral doses of 200-600 mg, the majority of patients with chronic myeloid leukaemia, Philadelphia chromosome-positive acute lymphoblastic leukemia expressing the BCR-ABL fusion protein and gastrointestinal stromal tumours (GIST) achieve a bio-molecular and clinical response, frequently complete, associated with limited toxicity.
Gene_expression (expressing) of BCR associated with toxicity, leukemia, philadelphia chromosome and gastrointestinal stromal tumor
1) Confidence 0.75 Published 2003 Journal J. Exp. Clin. Cancer Res. Section Abstract Doc Link 16767900 Disease Relevance 1.34 Pain Relevance 0.05
All PRP-OMPC formulations met prespecified acceptability criteria for postdose 3 immunogenicity for all antigens: PRP, HBsAg, pertussis, diphtheria, tetanus and polio.
Gene_expression (antigens) of all associated with polio, bordatella infection, anaerobic bacterial infections and diphtheria
2) Confidence 0.65 Published 2009 Journal Vaccine Section Abstract Doc Link 19124057 Disease Relevance 1.53 Pain Relevance 0.09
The chronic BCR-ABL negative myeloproliferative disorders (MPDs)
Neg (negative) Gene_expression (negative) of BCR associated with myeloproliferative disorder
3) Confidence 0.65 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721304 Disease Relevance 1.15 Pain Relevance 0
The MPDs (which include polycythemia vera (PV), essential thrombocythemia (ET), chronic eosinophilic leukemia (CEL), primary myelofibrosis (PMF), chronic myelomonocytic leukemia (CMML), and systemic mast cell disease (SMCD)) exclude chronic myeloid leukemia (CML) because of the pathognomic importance of the BCR-ABL translocation for the diagnosis and treatment of this disorder with imatinib mesylate.
Gene_expression (importance) of BCR in mast cell associated with leukemia, myeloid leukemia, myelofibrosis, myeloproliferative disorder, chronic myelomonocytic leukemia, hypereosinophilic syndrome, systemic mastocytosis and myelodysplastic syndromes
4) Confidence 0.65 Published 2007 Journal Biologics : Targets & Therapy Section Abstract Doc Link PMC2721304 Disease Relevance 2.25 Pain Relevance 0
Induced AV binding appeared BCR-selective in that it did not proceed in Bcl-2(high) cells in response to calcium ionophore or the antidepressant fluoxetine, each of which activate the full apoptotic program in Bcl-2(low) equivalents.
Gene_expression (selective) of BCR associated with antidepressant, apoptosis and fluoxetine
5) Confidence 0.65 Published 2006 Journal Leuk. Res. Section Abstract Doc Link 16076491 Disease Relevance 0.59 Pain Relevance 0.14
Peripheral blood RT-PCR for bcr-abl was negative.
Neg (negative) Gene_expression (negative) of bcr in blood
6) Confidence 0.58 Published 2008 Journal Leuk. Res. Section Abstract Doc Link 18308388 Disease Relevance 1.51 Pain Relevance 0.13
A total of 1,060 incident cases of hematopoietic malignancies were included: 764 cases of AL (646 ALL including 544 common B-cell ALL, 27 mature B-cell ALL, 67 T-cell ALL and 8 unspecified ALL, 100 AML and 18 unspecified or biphenotypic AL), 130 of HL, of whom 128 were > 4 years of age (79 nodular sclerosis, 19 mixed-cell, 18 lymphocyte predominant and 12 unspecified HL), and 166 NHL of whom 165 were > 1 year of age (76 Burkitt, 39 B-cell lymphoblastic, 27 T-cell lymphoblastic, 21 anaplasic large cell, and 2 unspecified NHL).
Gene_expression (including) of ALL in B-cell associated with leukemia, sclerosis, hodgkin's disease, acute myeloid leukemia and hematologic neoplasms
7) Confidence 0.51 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137105 Disease Relevance 2.15 Pain Relevance 0
A total of 1,060 incident cases of hematopoietic malignancies were included: 764 cases of AL (646 ALL including 544 common B-cell ALL, 27 mature B-cell ALL, 67 T-cell ALL and 8 unspecified ALL, 100 AML and 18 unspecified or biphenotypic AL), 130 of HL, of whom 128 were > 4 years of age (79 nodular sclerosis, 19 mixed-cell, 18 lymphocyte predominant and 12 unspecified HL), and 166 NHL of whom 165 were > 1 year of age (76 Burkitt, 39 B-cell lymphoblastic, 27 T-cell lymphoblastic, 21 anaplasic large cell, and 2 unspecified NHL).
Gene_expression (including) of ALL in B-cell associated with leukemia, sclerosis, hodgkin's disease, acute myeloid leukemia and hematologic neoplasms
8) Confidence 0.51 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137105 Disease Relevance 2.17 Pain Relevance 0
Additional analyses by AL subtype [acute lymphoblastic leukemia (ALL) and acute myeloblastic leukemia (AML)], ALL subtype (common B-cell ALL, mature B-cell ALL, and T-cell ALL), HL subtype (nodular sclerosis, mixed cellularity and lymphocyte predominant), and NHL subtype (Burkitt, B-cell lymphoblastic, T-cell lymphoblastic, and anaplastic large cell) were carried out.
Gene_expression (subtype) of ALL in lymphocyte associated with leukemia, sclerosis, hodgkin's disease and acute myeloid leukemia
9) Confidence 0.51 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137105 Disease Relevance 1.83 Pain Relevance 0
Additional analyses by AL subtype [acute lymphoblastic leukemia (ALL) and acute myeloblastic leukemia (AML)], ALL subtype (common B-cell ALL, mature B-cell ALL, and T-cell ALL), HL subtype (nodular sclerosis, mixed cellularity and lymphocyte predominant), and NHL subtype (Burkitt, B-cell lymphoblastic, T-cell lymphoblastic, and anaplastic large cell) were carried out.
Gene_expression (subtype) of ALL in lymphocyte associated with leukemia, sclerosis, hodgkin's disease and acute myeloid leukemia
10) Confidence 0.51 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137105 Disease Relevance 1.87 Pain Relevance 0
A total of 1,060 incident cases of hematopoietic malignancies were included: 764 cases of AL (646 ALL including 544 common B-cell ALL, 27 mature B-cell ALL, 67 T-cell ALL and 8 unspecified ALL, 100 AML and 18 unspecified or biphenotypic AL), 130 of HL, of whom 128 were > 4 years of age (79 nodular sclerosis, 19 mixed-cell, 18 lymphocyte predominant and 12 unspecified HL), and 166 NHL of whom 165 were > 1 year of age (76 Burkitt, 39 B-cell lymphoblastic, 27 T-cell lymphoblastic, 21 anaplasic large cell, and 2 unspecified NHL).
Gene_expression (including) of ALL in B-cell associated with leukemia, sclerosis, hodgkin's disease, acute myeloid leukemia and hematologic neoplasms
11) Confidence 0.51 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137105 Disease Relevance 2.24 Pain Relevance 0
Additional analyses by AL subtype [acute lymphoblastic leukemia (ALL) and acute myeloblastic leukemia (AML)], ALL subtype (common B-cell ALL, mature B-cell ALL, and T-cell ALL), HL subtype (nodular sclerosis, mixed cellularity and lymphocyte predominant), and NHL subtype (Burkitt, B-cell lymphoblastic, T-cell lymphoblastic, and anaplastic large cell) were carried out.
Gene_expression (subtype) of ALL in lymphocyte associated with leukemia, sclerosis, hodgkin's disease and acute myeloid leukemia
12) Confidence 0.51 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137105 Disease Relevance 1.89 Pain Relevance 0
Additional analyses by AL subtype [acute lymphoblastic leukemia (ALL) and acute myeloblastic leukemia (AML)], ALL subtype (common B-cell ALL, mature B-cell ALL, and T-cell ALL), HL subtype (nodular sclerosis, mixed cellularity and lymphocyte predominant), and NHL subtype (Burkitt, B-cell lymphoblastic, T-cell lymphoblastic, and anaplastic large cell) were carried out.
Gene_expression (subtype) of ALL in lymphocyte associated with leukemia, sclerosis, hodgkin's disease and acute myeloid leukemia
13) Confidence 0.51 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137105 Disease Relevance 1.83 Pain Relevance 0
Additional analyses by AL subtype [acute lymphoblastic leukemia (ALL) and acute myeloblastic leukemia (AML)], ALL subtype (common B-cell ALL, mature B-cell ALL, and T-cell ALL), HL subtype (nodular sclerosis, mixed cellularity and lymphocyte predominant), and NHL subtype (Burkitt, B-cell lymphoblastic, T-cell lymphoblastic, and anaplastic large cell) were carried out.
Gene_expression (subtype) of ALL in lymphocyte associated with leukemia, sclerosis, hodgkin's disease and acute myeloid leukemia
14) Confidence 0.51 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137105 Disease Relevance 1.82 Pain Relevance 0
A total of 1,060 incident cases of hematopoietic malignancies were included: 764 cases of AL (646 ALL including 544 common B-cell ALL, 27 mature B-cell ALL, 67 T-cell ALL and 8 unspecified ALL, 100 AML and 18 unspecified or biphenotypic AL), 130 of HL, of whom 128 were > 4 years of age (79 nodular sclerosis, 19 mixed-cell, 18 lymphocyte predominant and 12 unspecified HL), and 166 NHL of whom 165 were > 1 year of age (76 Burkitt, 39 B-cell lymphoblastic, 27 T-cell lymphoblastic, 21 anaplasic large cell, and 2 unspecified NHL).
Gene_expression (including) of ALL in B-cell associated with leukemia, sclerosis, hodgkin's disease, acute myeloid leukemia and hematologic neoplasms
15) Confidence 0.51 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137105 Disease Relevance 2.23 Pain Relevance 0
A total of 1,060 incident cases of hematopoietic malignancies were included: 764 cases of AL (646 ALL including 544 common B-cell ALL, 27 mature B-cell ALL, 67 T-cell ALL and 8 unspecified ALL, 100 AML and 18 unspecified or biphenotypic AL), 130 of HL, of whom 128 were > 4 years of age (79 nodular sclerosis, 19 mixed-cell, 18 lymphocyte predominant and 12 unspecified HL), and 166 NHL of whom 165 were > 1 year of age (76 Burkitt, 39 B-cell lymphoblastic, 27 T-cell lymphoblastic, 21 anaplasic large cell, and 2 unspecified NHL).
Gene_expression (including) of ALL in B-cell associated with leukemia, sclerosis, hodgkin's disease, acute myeloid leukemia and hematologic neoplasms
16) Confidence 0.51 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137105 Disease Relevance 2.16 Pain Relevance 0
Platter lists several examples: infants, old people, the whole human race (“all men in every age inasmuch as all their actions seem to be foolish as Erasmus and Brant have elegantly shown”), “fantastics” who excel in cleverness (ingenium) but whose love of being praised gives them “[asses'] ears” and leads them to buffoonery and ridiculous behaviour, people who are foolish when seized by strong emotions and, in the middle of this disparate list,
Gene_expression (men) of all in ears
17) Confidence 0.22 Published 2004 Journal Medical History Section Body Doc Link PMC547918 Disease Relevance 0.42 Pain Relevance 0
Inability to understand religion characterized the Christian laity in general, including the bottom rungs of the priesthood; these were all idiotae in that their faith was prescribed for them by the expertise of the ecclesiastical and social élite.
Gene_expression (idiotae) of all
18) Confidence 0.22 Published 2004 Journal Medical History Section Body Doc Link PMC547918 Disease Relevance 0.09 Pain Relevance 0
Platter lists several examples: infants, old people, the whole human race (“all men in every age inasmuch as all their actions seem to be foolish as Erasmus and Brant have elegantly shown”), “fantastics” who excel in cleverness (ingenium) but whose love of being praised gives them “[asses'] ears” and leads them to buffoonery and ridiculous behaviour, people who are foolish when seized by strong emotions and, in the middle of this disparate list,
Gene_expression (men) of all in ears
19) Confidence 0.22 Published 2004 Journal Medical History Section Body Doc Link PMC547918 Disease Relevance 0.42 Pain Relevance 0
When Paracelsus says in his prologue that the possibility of redemption “is greatly to be wondered at” in the case of the unwise, one might think his wonderment to be that even some of the intellectually disabled are redeemable.10 However it could mean that we are all redeemable in spite of the fact that we are all fools, qua human.
Gene_expression (fools) of all
20) Confidence 0.22 Published 2004 Journal Medical History Section Body Doc Link PMC547918 Disease Relevance 0.06 Pain Relevance 0

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