INT112036

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Context Info
Confidence 0.82
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 51
Total Number 51
Disease Relevance 18.59
Pain Relevance 25.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1) transport (Trpv1) plasma membrane (Trpv1)
transmembrane transport (Trpv1) lipid metabolic process (Trpv1)
Anatomy Link Frequency
neurons 3
nerve 2
PGE2 2
neuronal 1
sensory neurons 1
Trpv1 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 1630 100.00 Very High Very High Very High
Kinase C 169 100.00 Very High Very High Very High
Inflammation 575 99.76 Very High Very High Very High
Pain 1344 99.64 Very High Very High Very High
Nerve growth factor 187 99.24 Very High Very High Very High
Thermal hyperalgesia 193 99.12 Very High Very High Very High
Hyperalgesia 294 98.96 Very High Very High Very High
agonist 544 98.84 Very High Very High Very High
bradykinin 153 98.82 Very High Very High Very High
central sensitization 67 98.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 223 99.84 Very High Very High Very High
INFLAMMATION 605 99.76 Very High Very High Very High
Pain 1480 99.64 Very High Very High Very High
Hyperalgesia 601 99.12 Very High Very High Very High
Nociception 527 99.08 Very High Very High Very High
Ganglion Cysts 335 94.40 High High
Diabetes Mellitus 433 92.64 High High
Injury 71 90.56 High High
Neuropathic Pain 311 89.84 High High
Hypersensitivity 49 89.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Direct phosphorylation of TRPV1 by PKC epsilon was confirmed and the involved two serine residues were determined.
Phosphorylation (phosphorylation) of TRPV1
1) Confidence 0.82 Published 2003 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 12884755 Disease Relevance 0.60 Pain Relevance 1.25
Direct phosphorylation of TRPV1 by PKC was confirmed biochemically and the two serine residues involved were identified.
Phosphorylation (phosphorylation) of TRPV1
2) Confidence 0.82 Published 2004 Journal Novartis Found. Symp. Section Abstract Doc Link 15469041 Disease Relevance 0.22 Pain Relevance 0.50
In addition, propofol increased phosphorylation of PKCepsilon as well as TRPV1 and stimulated translocation of PKCepsilon from cytosolic to membrane fraction.
Phosphorylation (phosphorylation) of TRPV1
3) Confidence 0.82 Published 2010 Journal Anesthesiology Section Body Doc Link 20808213 Disease Relevance 0.05 Pain Relevance 0
DISCUSSION: Our results indicate that propofol modulates TRPV1 sensitivity to capsaicin and that this most likely occurs through a PKCepsilon-mediated phosphorylation of TRPV1.


Phosphorylation (phosphorylation) of TRPV1
4) Confidence 0.82 Published 2010 Journal Anesthesiology Section Body Doc Link 20808213 Disease Relevance 0 Pain Relevance 0
Phosphorylation of PKCepsilon and TRPV1 and the cellular translocation of PKCepsilon from cytosol to membrane compartments were assessed by immunoblot analysis.
Phosphorylation (Phosphorylation) of TRPV1
5) Confidence 0.82 Published 2010 Journal Anesthesiology Section Body Doc Link 20808213 Disease Relevance 0.09 Pain Relevance 0
PKC-mediated phosphorylation of TRPV1 in DRG neuronal cultures has been shown to produce faster activation and slower deactivation of the channel [4].
Phosphorylation (phosphorylation) of TRPV1 in neuronal
6) Confidence 0.81 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647151 Disease Relevance 0.17 Pain Relevance 0.32
PKC-mediated phos-phorylation of TRPV1 can reduce its activation threshold by partially activating the receptor such that lower concentrations of the agonist can fully activate the receptor [4, 138, 193].
Phosphorylation (phos) of TRPV1 associated with agonist
7) Confidence 0.81 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647151 Disease Relevance 0 Pain Relevance 0.16
Thus, CaMKII and calcineurin control the subtle balance between TRPV1 phosphorylation/dephosphory-lation and its activation, deactivation and desensitization characteristics.
Phosphorylation (phosphorylation) of TRPV1
8) Confidence 0.81 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647151 Disease Relevance 0.32 Pain Relevance 0.50
PKC-dependent phosphorylation of TRPV1 not only potentiates capsaicin- or proton-evoked responses but also reduces its temperature threshold for activation [39, 126, 168, 183].
Phosphorylation (phosphorylation) of TRPV1 associated with qutenza
9) Confidence 0.81 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647151 Disease Relevance 0.05 Pain Relevance 0.35
We have used near saturating concentrations of capsaicin and the differences in current amplitude suggest that the TRPV1 protein content as a result of altered transcriptional regulation is higher and lower in hyper and hypoalgesic mice, respectively rather than phosphorylation state of TRPV1, where they showed prolongation of decay phase [41].


Phosphorylation (phosphorylation) of TRPV1 associated with qutenza
10) Confidence 0.81 Published 2008 Journal Mol Pain Section Body Doc Link PMC2275252 Disease Relevance 1.27 Pain Relevance 0.55
Mutants of CaMKII phosphorylation sites on TRPV1 (S502 and T704) failed to elicit currents in response to application of capsaicin or RTX [83].
Phosphorylation (phosphorylation) of TRPV1 associated with qutenza
11) Confidence 0.81 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647151 Disease Relevance 0.35 Pain Relevance 0.57
A PKA-dependent pathway took a relatively long time to exert its potentiating effects on TRPV1 activity, suggesting some difference between PKA- and PKC-dependent phosphorylation of TRPV1.
Phosphorylation (phosphorylation) of TRPV1
12) Confidence 0.80 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074353 Disease Relevance 0.30 Pain Relevance 0.33
We also show that the expression level of PKCepsilon paralleled the amount of phosphorylated TRPV1 protein using an antibody specific for phosphorylated TRPV1 at S800.
Phosphorylation (phosphorylated) of TRPV1
13) Confidence 0.80 Published 2006 Journal Pain Section Abstract Doc Link 16564619 Disease Relevance 0.21 Pain Relevance 0.20
Since S502 is a non-specific substrate for TRPV1 phosphorylation by kinases like PKC, PKA or CAMKII, evidence for a role of PKC specific substrate S800 was investigated.
Phosphorylation (phosphorylation) of TRPV1
14) Confidence 0.80 Published 2006 Journal Pain Section Abstract Doc Link 16564619 Disease Relevance 0.21 Pain Relevance 0.23
Evidence for in vivo phosphorylation of TRPV1 at S800 was demonstrated for the first time.
Phosphorylation (phosphorylation) of TRPV1
15) Confidence 0.80 Published 2006 Journal Pain Section Abstract Doc Link 16564619 Disease Relevance 0.21 Pain Relevance 0.21
Furthermore, the anti-phosphoTRPV1 antibody detected phosphorylation of TRPV1 in mouse and rat DRG neurons and may be useful for research regarding nociception in native tissues.
Phosphorylation (phosphorylation) of TRPV1 in neurons associated with nociception
16) Confidence 0.80 Published 2006 Journal Pain Section Abstract Doc Link 16564619 Disease Relevance 0.21 Pain Relevance 0.18
We also show that the expression level of PKCepsilon paralleled the amount of phosphorylated TRPV1 protein using an antibody specific for phosphorylated TRPV1 at S800.
Phosphorylation (phosphorylated) of TRPV1
17) Confidence 0.80 Published 2006 Journal Pain Section Abstract Doc Link 16564619 Disease Relevance 0.21 Pain Relevance 0.19
TRPV1 has two putative substrates S502 and S800 for PKCepsilon-mediated phosphorylation.
Phosphorylation (phosphorylation) of TRPV1
18) Confidence 0.79 Published 2006 Journal Pain Section Abstract Doc Link 16564619 Disease Relevance 0.18 Pain Relevance 0.27
Mutation at PKC-specific TRPV1 phosphorylation sites (S800A/S502A) and PKC inhibitors inhibited the potentiating effect of ET-1.
Phosphorylation (phosphorylation) of TRPV1 associated with kinase c
19) Confidence 0.79 Published 2008 Journal Neuroscience Section Abstract Doc Link 18495351 Disease Relevance 0.56 Pain Relevance 1.04
In addition, Western blot analysis was also performed to confirm ET-1-induced phosphorylation of TRPV1.
Phosphorylation (phosphorylation) of TRPV1
20) Confidence 0.79 Published 2008 Journal Neuroscience Section Abstract Doc Link 18495351 Disease Relevance 0.34 Pain Relevance 0.85

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