INT112038

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Context Info
Confidence 0.45
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 2.41
Pain Relevance 4.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2ry2) mitochondrion (P2ry2) plasma membrane (P2ry2)
lysosome (P2ry2) signal transducer activity (P2ry2)
Anatomy Link Frequency
astrocytes 1
platelet 1
P2ry2 (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 19 100.00 Very High Very High Very High
bradykinin 16 100.00 Very High Very High Very High
Kinase C 26 99.96 Very High Very High Very High
Inflammatory mediators 4 99.88 Very High Very High Very High
qutenza 77 99.60 Very High Very High Very High
adenocard 2 99.52 Very High Very High Very High
nociceptor 141 98.56 Very High Very High Very High
Glutamate 11 98.44 Very High Very High Very High
Pain 122 97.88 Very High Very High Very High
algogenic 3 95.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 48 99.68 Very High Very High Very High
Rheumatoid Arthritis 68 98.20 Very High Very High Very High
Pain 119 97.88 Very High Very High Very High
Targeted Disruption 25 88.96 High High
Disease 17 88.28 High High
Hyperalgesia 58 87.96 High High
Injury 14 86.80 High High
Necrosis 2 83.20 Quite High
Nociception 41 75.00 Quite High
Cv General 3 Under Development 2 65.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Whereas P2X receptors are receptors of ATP, the different P2Y receptors are activated by distinct nucleotides, diphosphates or triphosphates, or purines or pyrimidines, some of them being conjugated to sugars.
Positive_regulation (activated) of P2Y
1) Confidence 0.45 Published 2005 Journal Semin. Thromb. Hemost. Section Abstract Doc Link 15852217 Disease Relevance 0.30 Pain Relevance 0.15
Once in the extracellular fluids, they are rapidly degraded by ectonucleotidases, such as CD39, that play a key role in neutralizing the platelet aggregatory action of adenosine diphosphate (ADP), and act on two families of receptors: the ionotropic P2X receptors and the G-protein-coupled P2Y receptors.
Positive_regulation (act) of P2Y in platelet associated with adenocard
2) Confidence 0.39 Published 2005 Journal Semin. Thromb. Hemost. Section Abstract Doc Link 15852217 Disease Relevance 0.21 Pain Relevance 0.11
Thus it is likely that UTP activation of P2Y2 leads to a Gq-dependent potentiation of the RA current which does not require prior activation of PKC.
Positive_regulation (activation) of P2Y2 associated with kinase c and rheumatoid arthritis
3) Confidence 0.33 Published 2009 Journal The Journal of Physiology Section Body Doc Link PMC2742277 Disease Relevance 0.31 Pain Relevance 0.51
Taken together these data imply that activation of P2Y2/P2Y4 receptors on astrocytes causes inhibition of SCO.
Positive_regulation (activation) of P2Y2 in astrocytes
4) Confidence 0.26 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2518726 Disease Relevance 0 Pain Relevance 0.03
P2Y2 receptors are coupled to Gq-proteins and can thus in principal also activate PKC pathways (von Kugelgen & Wetter, 2000).
Positive_regulation (activate) of P2Y2 associated with kinase c
5) Confidence 0.24 Published 2009 Journal The Journal of Physiology Section Body Doc Link PMC2742277 Disease Relevance 0.19 Pain Relevance 0.77
At this exposure time, P2Y receptors responses in satellite glia were instead upregulated, suggesting a complex modulation of P2 receptors in pain signaling.
Positive_regulation (upregulated) of P2Y associated with pain
6) Confidence 0.21 Published 2008 Journal Cell Calcium Section Abstract Doc Link 18031810 Disease Relevance 0.42 Pain Relevance 0.56
Prostaglandin E2 (PGE2), bradykinin, NGF, extracellular ATP, glutamate, trypsin, prolactin, prokineticin2 (Bv8) are pro-inflammatory mediators that activate their respective receptors EP prostaglandin, B1/B2 bradykinin, high-affinity TrkA NGF receptor, P2Y2, mGlu 5, PAR-2, PRLR and PKR2 G protein-coupled receptors [48, 96, 148, 221].
Positive_regulation (activate) of P2Y2 associated with inflammatory mediators, glutamate, nerve growth factor and bradykinin
7) Confidence 0.07 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645548 Disease Relevance 0.33 Pain Relevance 0.79
In cells expressing TRPV1, ATP or bradykinin increased the currents evoked by capsaicin or protons through activation of metabotropic P2Y or B2 bradykinin receptors.
Positive_regulation (activation) of P2Y associated with qutenza and bradykinin
8) Confidence 0.04 Published 2003 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 12884755 Disease Relevance 0.66 Pain Relevance 1.34
We have reported that Gq/11-coupled metabotropic receptor activation such as ATP (P2Y), bradykinin (B2) and proteinase-activated receptor 2 (PAR2) receptors causes potentiation or sensitization of TRPV1 through the PKC-dependent phosphorylation of TRPV1 [16-18,25].
Positive_regulation (activation) of P2Y associated with bradykinin
9) Confidence 0.01 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074353 Disease Relevance 0 Pain Relevance 0.13

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