INT11204

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Context Info
Confidence 0.60
First Reported 1989
Last Reported 2007
Negated 2
Speculated 3
Reported most in Abstract
Documents 11
Total Number 14
Disease Relevance 1.01
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prep) peptidase activity (Prep) nucleus (Prep)
cytoplasm (Prep)
Anatomy Link Frequency
VMN 4
neurons 2
brain 2
pituitary 2
Purkinje cells 2
Prep (Rattus norvegicus)
Pain Link Frequency Relevance Heat
alcohol 12 99.62 Very High Very High Very High
antagonist 1 98.42 Very High Very High Very High
Intracerebroventricular 1 96.84 Very High Very High Very High
Enkephalin 22 95.64 Very High Very High Very High
Opioid 2 92.52 High High
Endogenous opioid 2 88.72 High High
Neuropeptide 4 78.72 Quite High
Anterior cingulate cortex 35 54.36 Quite High
Pyramidal cell 31 53.08 Quite High
Dopamine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 85 99.84 Very High Very High Very High
Lordosis 9 96.92 Very High Very High Very High
Urological Neuroanatomy 3 91.08 High High
Body Weight 15 5.00 Very Low Very Low Very Low
Anxiety Disorder 4 5.00 Very Low Very Low Very Low
Disseminated Intravascular Coagulation 2 5.00 Very Low Very Low Very Low
Overdose 1 5.00 Very Low Very Low Very Low
Schizophrenia 1 5.00 Very Low Very Low Very Low
Frailty 1 5.00 Very Low Very Low Very Low
Cognitive Disorder 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition we have examined the effects of progesterone on PE gene expression in the VL-VM of estrogen-primed rats.
Spec (examined) Regulation (effects) of Gene_expression (expression) of PE gene
1) Confidence 0.60 Published 1989 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 2927283 Disease Relevance 0 Pain Relevance 0
Together, the short latency of the estrogen-induced elevation and the rapid rate of decay following estrogen removal indicate that PE gene expression is highly sensitive to fluctuating estrogen levels.
Regulation (sensitive) of Gene_expression (expression) of PE gene
2) Confidence 0.60 Published 1989 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 2927283 Disease Relevance 0 Pain Relevance 0
These results indicate that estrogen regulation of PE gene expression in the VL-VM is sexually differentiated and support the hypothesis that the enkephalinergic neurons of the VL-VM are involved in the regulation of female reproductive behavior.
Regulation (regulation) of Gene_expression (expression) of PE gene in neurons
3) Confidence 0.53 Published 1990 Journal Brain Res. Section Abstract Doc Link 1707724 Disease Relevance 0.19 Pain Relevance 0
Testosterone treatment of gonadectomized males also had no effect on PE gene expression.
Neg (no) Regulation (effect) of Gene_expression (expression) of PE gene
4) Confidence 0.53 Published 1990 Journal Brain Res. Section Abstract Doc Link 1707724 Disease Relevance 0.14 Pain Relevance 0.08
Overall, these data indicate that the estrogen responsiveness of PE mRNA expression in the VMN declines with age and, furthermore, prenatal exposure to alcohol blunts estrogen's effects on PE mRNA expression in the adult VMN.
Regulation (effects) of Gene_expression (expression) of PE mRNA in VMN associated with alcohol
5) Confidence 0.45 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9221919 Disease Relevance 0 Pain Relevance 0.18
To determine whether there is a sex difference in steroid hormone regulation of PE gene expression we have examined the effects of estrogen and testosterone on PE mRNA levels in male rats.
Spec (whether) Regulation (regulation) of Gene_expression (expression) of PE gene
6) Confidence 0.39 Published 1990 Journal Brain Res. Section Abstract Doc Link 1707724 Disease Relevance 0.10 Pain Relevance 0.10
Overall, these data indicate that the estrogen responsiveness of PE mRNA expression in the VMN declines with age and, furthermore, prenatal exposure to alcohol blunts estrogen's effects on PE mRNA expression in the adult VMN.
Regulation (responsiveness) of Gene_expression (expression) of PE mRNA in VMN associated with alcohol
7) Confidence 0.27 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9221919 Disease Relevance 0 Pain Relevance 0.19
These results indicate that the ontogeny of PE mRNA expression in Purkinje cells is developmentally regulated since levels of expression closely follow the chronological order of settling and maturation of these neurons.
Regulation (regulated) of Gene_expression (expression) of PE mRNA in Purkinje cells
8) Confidence 0.22 Published 1991 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 1790599 Disease Relevance 0 Pain Relevance 0.09
The effect of culture density on the expression of PE mRNA was also examined.
Regulation (effect) of Gene_expression (expression) of PE mRNA
9) Confidence 0.20 Published 1992 Journal Brain Res. Section Abstract Doc Link 1540832 Disease Relevance 0.15 Pain Relevance 0.08
Previous intracerebroventricular (i.c.v.) administration of the type II glucocorticoid receptor (GR) antagonist RU-486 (20 ng/rat), increased the basal CRH mRNA levels in the PVN but had no effect on PE gene expression.
Neg (no) Regulation (effect) of Gene_expression (expression) of PE gene in PVN associated with antagonist and intracerebroventricular
10) Confidence 0.19 Published 1998 Journal Brain Res. Section Abstract Doc Link 9555022 Disease Relevance 0.35 Pain Relevance 0.10
Chronic exposure to GHB (500 mg/kg i.p. twice a day) for 10 days induced significant increases in both PE and PD mRNA levels in different brain regions examined, suggesting that PD and PE mRNA expressions are modulated by the endogenous GHBergic system.
Regulation (modulated) of Gene_expression (expressions) of PE mRNA in brain
11) Confidence 0.17 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10076874 Disease Relevance 0.09 Pain Relevance 0
Hypophysectomy prior to the onset of puberty was found to drastically reduce the level of PE mRNA in the testis and epididymus, suggesting that pituitary factors affect the expression of the PE gene in these tissues, either directly or indirectly.
Regulation (affect) of Gene_expression (expression) of PE gene in pituitary
12) Confidence 0.17 Published 1990 Journal NIDA Res. Monogr. Section Abstract Doc Link 1875991 Disease Relevance 0 Pain Relevance 0.17
Therefore, we examined the effect of gonadectomy with or without four weeks of hormone treatment on PE mRNA expression in adult male Fisher 344 rats using quantitative in situ hybridization histochemistry.
Spec (examined) Regulation (effect) of Gene_expression (expression) of PE mRNA
13) Confidence 0.09 Published 1993 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8361335 Disease Relevance 0 Pain Relevance 0.09
Bonferroni's post hoc test showed reliable
Regulation (Bonferroni) of Gene_expression (test) of post
14) Confidence 0.03 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1975761 Disease Relevance 0 Pain Relevance 0.05

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