INT112040

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Context Info
Confidence 0.73
First Reported 2003
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 4.69
Pain Relevance 4.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
afferent neurons 2
ureter 1
bladder 1
intestine 1
P2RX2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Visceral pain 3 99.76 Very High Very High Very High
analgesia 12 97.56 Very High Very High Very High
Pain 108 97.20 Very High Very High Very High
Neurotransmitter 4 96.20 Very High Very High Very High
IPN 7 91.48 High High
Inflammation 40 86.96 High High
burning pain 2 84.36 Quite High
bradykinin 6 80.08 Quite High
Spinal cord 9 80.00 Quite High
Inflammatory mediators 7 79.20 Quite High
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

3 99.76 Very High Very High Very High
Nociception 25 97.96 Very High Very High Very High
Pain 138 97.20 Very High Very High Very High
Inflammatory Pain 7 91.48 High High
Injury 12 88.40 High High
INFLAMMATION 47 86.96 High High
Osteoarthritis 1 82.24 Quite High
Neuropathic Pain 28 74.24 Quite High
Hyperalgesia 11 68.92 Quite High
Frailty 48 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Purinergic mechanosensory transduction has been proposed for visceral pain, where ATP released from epithelial cells lining the bladder, ureter, and intestine during distension acts on P2X3 and P2X2/3, and possibly P2Y, receptors on subepithelial sensory nerve fibers to send messages to the pain centers in the brain as well as initiating local reflexes.
Localization (released) of P2X2 in bladder associated with pain and visceral pain
1) Confidence 0.73 Published 2006 Journal Pharmacol. Ther. Section Abstract Doc Link 16226312 Disease Relevance 0.72 Pain Relevance 0.86
Functional homomeric (P2X(3)) and heteromeric (P2X(2/3)) receptors are highly localised on primary sensory afferent neurons that transmit nociceptive sensory information.
Localization (localised) of P2X in afferent neurons associated with nociception
2) Confidence 0.28 Published 2003 Journal Expert Opin. Ther. Targets Section Abstract Doc Link 12885270 Disease Relevance 0.53 Pain Relevance 0.26
Functional homomeric (P2X(3)) and heteromeric (P2X(2/3)) receptors are highly localised on primary sensory afferent neurons that transmit nociceptive sensory information.
Localization (localised) of P2X in afferent neurons associated with nociception
3) Confidence 0.28 Published 2003 Journal Expert Opin. Ther. Targets Section Abstract Doc Link 12885270 Disease Relevance 0.53 Pain Relevance 0.26
Purinergic mechanosensory transduction has been proposed for visceral pain, where ATP released from epithelial cells lining the bladder, ureter, and intestine during distension acts on P2X3 and P2X2/3, and possibly P2Y, receptors on subepithelial sensory nerve fibers to send messages to the pain centers in the brain as well as initiating local reflexes.
Localization (released) of P2X2 in ureter associated with pain and visceral pain
4) Confidence 0.25 Published 2006 Journal Pharmacol. Ther. Section Abstract Doc Link 16226312 Disease Relevance 0.72 Pain Relevance 0.86
Purinergic mechanosensory transduction has been proposed for visceral pain, where ATP released from epithelial cells lining the bladder, ureter, and intestine during distension acts on P2X3 and P2X2/3, and possibly P2Y, receptors on subepithelial sensory nerve fibers to send messages to the pain centers in the brain as well as initiating local reflexes.
Localization (released) of P2X2 in intestine associated with pain and visceral pain
5) Confidence 0.25 Published 2006 Journal Pharmacol. Ther. Section Abstract Doc Link 16226312 Disease Relevance 0.72 Pain Relevance 0.86
The unique localization of the purinergic 2X ionotropic (P2X)3 receptor to small sensory fibres has highlighted its importance in pain.
Localization (localization) of P2X associated with pain
6) Confidence 0.04 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206352 Disease Relevance 1.18 Pain Relevance 1.21

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