INT112054

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Context Info
Confidence 0.44
First Reported 2003
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 5.02
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (DMD) cytoskeleton (DMD) nucleus (DMD)
cytoplasm (DMD)
Anatomy Link Frequency
femur 4
liver 2
hip 2
spine 2
proximal 2
DMD (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 2 97.10 Very High Very High Very High
cytokine 9 96.12 Very High Very High Very High
referred pain 1 92.88 High High
backache 6 70.60 Quite High
Pain 41 69.12 Quite High
cva 19 5.00 Very Low Very Low Very Low
rheumatoid arthritis 13 5.00 Very Low Very Low Very Low
withdrawal 7 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
corticosteroid 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stroke 22 100.00 Very High Very High Very High
Cirrhosis 20 100.00 Very High Very High Very High
Osteoporosis 317 99.76 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 71 99.12 Very High Very High Very High
Cleidocranial Dysplasia 2 98.12 Very High Very High Very High
Infection 19 97.30 Very High Very High Very High
Osteoarthritis 2 97.10 Very High Very High Very High
Osteogenesis Imperfecta 24 96.16 Very High Very High Very High
Disease 46 93.48 High High
Referred Pain 1 92.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similarly, a 2-year brisk walking regimen significantly reduced loss of BMD at femoral neck, but there was no difference at the spine BMD [22].
Negative_regulation (reduced) of Negative_regulation (loss) of BMD in spine
1) Confidence 0.44 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3022164 Disease Relevance 0 Pain Relevance 0
Our data demonstrate that compliance to parenteral CLD is satisfactory and that this drug reduces bone turnover, increases the L1-L4 BMD and decreases the FN BMD loss.
Negative_regulation (decreases) of Negative_regulation (loss) of BMD
2) Confidence 0.42 Published 2003 Journal Ann. Ital. Med. Int. Section Abstract Doc Link 12886826 Disease Relevance 0.26 Pain Relevance 0.09
An antiresorptive should be added after a course of teriparatide is completed to prevent loss of BMD.



Negative_regulation (prevent) of Negative_regulation (loss) of BMD
3) Confidence 0.10 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2686338 Disease Relevance 0.43 Pain Relevance 0
The losses of the lumbar BMD in patients with liver cirrhosis and the metacarpal BMD in hemiplegic patients after stroke are prevented, and the lumbar BMD is possibly increased, preventing fragile fractures in adult patients with osteogenesis imperfecta type I.
Negative_regulation (prevented) of Negative_regulation (losses) of BMD in liver associated with cirrhosis, stroke and osteogenesis imperfecta
4) Confidence 0.07 Published 2005 Journal Yonsei Medical Journal Section Abstract Doc Link PMC2815806 Disease Relevance 1.31 Pain Relevance 0.13
Yamaguchi et al.28 showed in a randomized controlled study conducted on 42 patients with osteoarthritis of the hip joint secondary to acetabular dysplasia that 12 months of treatment with cyclical etidronate (400 mg/day for 2 weeks every 14 weeks) reduced the BMD loss in the proximal femur after cementless THA by decreasing the serum bone-specific alkaline phosphatase (BAP) and urinary NTX levels, suggesting that etidronate treatment may reduce proximal bone resorption around the femoral stem and help prevent some of the complications in patients undergoing cementless THA.


Negative_regulation (reduced) of Negative_regulation (loss) of BMD in proximal associated with cleidocranial dysplasia, hypercalcemia and osteoarthritis
5) Confidence 0.07 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2815806 Disease Relevance 1.02 Pain Relevance 0.18
Only time with HIV infection and not specific therapy was associated with BMD decreases 83 patients not receiving antiretrovirals also have a higher than expected prevalence of reduced BMD, which suggests that HIV itself may be a contributing factor, mediated by immune activation and cytokines 84
Negative_regulation (prevalence) of Negative_regulation (reduced) of BMD associated with acquired immune deficiency syndrome or hiv infection, infection and cytokine
6) Confidence 0.05 Published 2004 Journal International Journal of Medical Sciences Section Body Doc Link PMC1074710 Disease Relevance 1.19 Pain Relevance 0.05
Letrozole has also recently been shown to result in significantly greater loss of BMD at total hip (?
Negative_regulation (result) of Negative_regulation (loss) of BMD in hip
7) Confidence 0.05 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682397 Disease Relevance 0.45 Pain Relevance 0
However, interruption of treatment is followed by a rapid decrease of BMD, which can be prevented by subsequent treatment with a biphosphonate [115].
Negative_regulation (prevented) of Negative_regulation (decrease) of BMD
8) Confidence 0.04 Published 2010 Journal Osteoporos Int Section Body Doc Link PMC2931762 Disease Relevance 0.21 Pain Relevance 0
The primary objective of this investigation was to determine if a diet high in natural RS2 from high-amylose cornstarch (also termed "maize starch") can reduce or prevent loss of femur BMD and BMC subsequent to weight cycling in female rats.
Negative_regulation (prevent) of Negative_regulation (loss) of BMD in femur
9) Confidence 0.01 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2631000 Disease Relevance 0.08 Pain Relevance 0
The results provide the first evidence that a dietary component, in this case RS2, can prevent or reduce loss of BMD and BMC due to weight cycling.
Negative_regulation (prevent) of Negative_regulation (loss) of BMD
10) Confidence 0.01 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2631000 Disease Relevance 0 Pain Relevance 0
The primary objective of this investigation was to determine if a diet high in natural RS2 from high-amylose cornstarch (also termed "maize starch") can reduce or prevent loss of femur BMD and BMC subsequent to weight cycling in female rats.
Negative_regulation (reduce) of Negative_regulation (loss) of BMD in femur
11) Confidence 0.01 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2631000 Disease Relevance 0.08 Pain Relevance 0
The results provide the first evidence that a dietary component, in this case RS2, can prevent or reduce loss of BMD and BMC due to weight cycling.
Negative_regulation (reduce) of Negative_regulation (loss) of BMD
12) Confidence 0.01 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2631000 Disease Relevance 0 Pain Relevance 0

General Comments

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