INT11206

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Context Info
Confidence 0.60
First Reported 1988
Last Reported 2007
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 5
Disease Relevance 1.06
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prep) peptidase activity (Prep) nucleus (Prep)
cytoplasm (Prep)
Anatomy Link Frequency
hypothalamus 2
gonadal 2
brain 2
Prep (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Anterior cingulate cortex 70 94.64 High High
Pyramidal cell 62 83.76 Quite High
Enkephalin 4 74.28 Quite High
Neuropeptide 4 63.60 Quite High
Dopamine 12 5.00 Very Low Very Low Very Low
amygdala 10 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Ventral tegmentum 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 160 97.36 Very High Very High Very High
Urological Neuroanatomy 2 96.32 Very High Very High Very High
Lordosis 3 75.56 Quite High
Body Weight 30 5.00 Very Low Very Low Very Low
Anxiety Disorder 8 5.00 Very Low Very Low Very Low
Disseminated Intravascular Coagulation 4 5.00 Very Low Very Low Very Low
Overdose 2 5.00 Very Low Very Low Very Low
Schizophrenia 2 5.00 Very Low Very Low Very Low
Frailty 2 5.00 Very Low Very Low Very Low
Cognitive Disorder 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine whether the sex difference in estrogen-inducibility of PE gene expression is due to the developmental effects of gonadal steroids, we have investigated the effect of estrogen on PE mRNA levels in the VL-VM of neonatally androgenized female rats.
Spec (whether) Positive_regulation (inducibility) of Gene_expression (expression) of PE gene in gonadal
1) Confidence 0.60 Published 1990 Journal Brain Res. Section Abstract Doc Link 1707724 Disease Relevance 0.19 Pain Relevance 0.07
Slot blot hybridization analysis indicates that the levels of PE mRNA in the ventromedial hypothalamus of ovariectomized rats increase 3.1-fold after 2 weeks of estrogen replacement.
Positive_regulation (increase) of Gene_expression (levels) of PE mRNA in hypothalamus
2) Confidence 0.46 Published 1988 Journal Mol. Endocrinol. Section Abstract Doc Link 2464133 Disease Relevance 0 Pain Relevance 0
While the percentages of cultured astrocytes expressing high levels of PE mRNA varied slightly between brain region (24-28%), the level of PE mRNA expression per cell showed greater variation between regions.
Positive_regulation (levels) of Gene_expression (expressing) of PE mRNA in brain
3) Confidence 0.15 Published 1992 Journal Brain Res. Section Abstract Doc Link 1540832 Disease Relevance 0.16 Pain Relevance 0.06
However, the post
Positive_regulation (However) of Gene_expression (However) of post
4) Confidence 0.03 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1975761 Disease Relevance 0.70 Pain Relevance 0.11
However, the post hoc
Positive_regulation (However) of Gene_expression (However) of post
5) Confidence 0.03 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1975761 Disease Relevance 0 Pain Relevance 0.22

General Comments

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