INT112062

Context Info Confidence 0.01 First Reported 2003 Last Reported 2003 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.14 Pain Relevance 0.22

Anatomy Link Frequency prefrontal 2 Kcnk2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat dopamine receptor 1 100.00 Glutamate 1 98.12 Nucleus accumbens 2 95.00 gABA 1 75.00 Dopamine 1 75.00 Enkephalin 1 25.00

Disease Link Frequency Relevance Heat Schizophrenia 2 75.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We used in situ hybridization histochemistry to assess expression of dopamine receptors (D1R, D2R and D3R), neurotensin, proenkephalin and glutamate decarboxylase-67 (GAD67) in the prefrontal cortex, striatum, and/or nucleus accumbens in adult rats with neonatal ventral hippocampal (VH) lesions and in control animals after acute and chronic treatment with antipsychotic drugs clozapine and haloperidol.

Positive_regulation (assess) of Gene_expression (expression) of D1R in prefrontal associated with nucleus accumbens, glutamate and dopamine receptor

1) Confidence 0.01 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12887421 Disease Relevance 0.14 Pain Relevance 0.22

General Comments

This test has worked.