INT112063

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Context Info
Confidence 0.09
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Title
Documents 2
Total Number 4
Disease Relevance 1.84
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Drd3) signal transducer activity (Drd3)
Anatomy Link Frequency
cerebral cortex 3
brain 2
nucleus 2
cerebellum 1
Drd3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cerebral cortex 111 99.68 Very High Very High Very High
addiction 6 97.48 Very High Very High Very High
long-term potentiation 3 94.68 High High
dopamine receptor 37 92.48 High High
Inflammation 3 91.24 High High
Nucleus accumbens 2 81.20 Quite High
Dopamine 118 75.00 Quite High
gABA 4 75.00 Quite High
Glutamate 7 67.04 Quite High
Neurotransmitter 33 44.72 Quite Low
Disease Link Frequency Relevance Heat
Drug Dependence 6 97.48 Very High Very High Very High
Diabetes Mellitus 270 97.40 Very High Very High Very High
INFLAMMATION 3 91.24 High High
Schizophrenia 5 83.28 Quite High
Cognitive Disorder 33 40.28 Quite Low
Stress 27 5.00 Very Low Very Low Very Low
Body Weight 15 5.00 Very Low Very Low Very Low
Apoptosis 12 5.00 Very Low Very Low Very Low
Hyperglycemia 12 5.00 Very Low Very Low Very Low
Cerebellar Diseases 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is therefore important to identify the elements that modulate dopaminergic receptor expressions and phosphorylation of CREB and there by its expression in the nucleus.
Regulation (modulate) of Gene_expression (expressions) of dopaminergic receptor in nucleus
1) Confidence 0.09 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2890658 Disease Relevance 0.46 Pain Relevance 0.36
Curcumin modulates dopaminergic receptor, CREB and phospholipase c gene expression in the cerebral cortex and cerebellum of streptozotocin induced diabetic rats

Curcumin, an active principle component in rhizome of Curcuma longa, has proved its merit for diabetes through its anti-oxidative and anti-inflammatory properties.

Regulation (modulates) of Gene_expression (expression) of dopaminergic receptor in cerebral cortex associated with inflammation, diabetes mellitus and cerebral cortex
2) Confidence 0.08 Published 2010 Journal J Biomed Sci Section Title Doc Link PMC2890658 Disease Relevance 0.61 Pain Relevance 0.37
Curcumin modulates dopaminergic receptor, CREB and phospholipase c gene expression in the cerebral cortex and cerebellum of streptozotocin induced diabetic rats

Curcumin, an active principle component in rhizome of Curcuma longa, has proved its merit for diabetes through its anti-oxidative and anti-inflammatory properties.

Regulation (modulates) of in cerebellum Gene_expression (expression) of dopaminergic receptor in cerebral cortex associated with inflammation, diabetes mellitus and cerebral cortex
3) Confidence 0.03 Published 2010 Journal J Biomed Sci Section Title Doc Link PMC2890658 Disease Relevance 0.61 Pain Relevance 0.37
Antipsychotic drugs did not alter expression of D1R, D2R or D3R receptor mRNAs but elevated neurotensin and proenkephalin expression in both groups of rats; patterns of changes were dependent on the duration of treatment and brain area examined.
Neg (not) Regulation (alter) of Gene_expression (expression) of D3R receptor in brain
4) Confidence 0.02 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12887421 Disease Relevance 0.16 Pain Relevance 0.22

General Comments

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