INT11207

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Context Info
Confidence 0.46
First Reported 1986
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 0.17
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Cpe) extracellular space (Cpe) Golgi apparatus (Cpe)
Anatomy Link Frequency
astrocytes 2
Cpe (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 13 100.00 Very High Very High Very High
Enkephalin 6 100.00 Very High Very High Very High
Dopamine 124 98.24 Very High Very High Very High
Kinase C 60 92.72 High High
Thalamus 2 88.72 High High
gABA 8 5.00 Very Low Very Low Very Low
Neurotransmitter 8 5.00 Very Low Very Low Very Low
addiction 8 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
cocaine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 2 99.48 Very High Very High Very High
Disease 12 5.00 Very Low Very Low Very Low
Stress 12 5.00 Very Low Very Low Very Low
Obesity 8 5.00 Very Low Very Low Very Low
Drug Dependence 8 5.00 Very Low Very Low Very Low
Sprains And Strains 4 5.00 Very Low Very Low Very Low
Neurological Disease 4 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Schizophrenia 4 5.00 Very Low Very Low Very Low
Cognitive Disorder 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The percentage of cultured astrocytes expressing high levels of CPE mRNA was 42% for frontal cortex astrocytes and 23% for cerebellar astrocytes.
Positive_regulation (levels) of Gene_expression (expressing) of CPE mRNA in astrocytes associated with urological neuroanatomy
1) Confidence 0.46 Published 1992 Journal Brain Res. Section Abstract Doc Link 1540832 Disease Relevance 0.17 Pain Relevance 0.08
The expression of enkephalin convertase prior to that of most neuropeptides supports a role for this enzyme in propeptide processing.
Positive_regulation (role) of Gene_expression (expression) of enkephalin convertase associated with neuropeptide and enkephalin
2) Confidence 0.34 Published 1986 Journal Brain Res. Section Abstract Doc Link 3021286 Disease Relevance 0 Pain Relevance 0.56
Thus, the increased surface expression of DAT by CPE may involve phosphorylation events.
Positive_regulation (increased) of Gene_expression (expression) of CPE
3) Confidence 0.30 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.15
As illustrated in Fig 2A, CPE coexpression significantly increased the maximal uptake velocity (Vmax) of [3H] DA by ~50% (DAT: Vmax = 10.8 ± 1 pmol/min/well; DAT+CPE: 16 ± 1.9 pmol/min/well; P < 0.01), whereas no significant change in the estimated Km of the DAT could be observed (DAT: Km = 6.6 ± 0.7 ?
Positive_regulation (increased) of Gene_expression (coexpression) of CPE associated with dopamine
4) Confidence 0.30 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.17
In addition, immunofluorescence analysis demonstrated that co-expression of CPE and DAT facilitated surface translocation of both proteins.
Positive_regulation (facilitated) of Gene_expression (expression) of CPE
5) Confidence 0.30 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.18
As shown in Fig 3, coexpression of CPE increased the levels of both total DAT and cell surface DAT to about ~20% (Fig. 3A, B).
Positive_regulation (increased) of Gene_expression (coexpression) of CPE
6) Confidence 0.27 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.18

General Comments

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