INT112070

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Context Info
Confidence 0.59
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Title
Documents 6
Total Number 6
Disease Relevance 3.72
Pain Relevance 3.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pparg) signal transduction (Pparg) nucleus (Pparg)
enzyme binding (Pparg) DNA binding (Pparg) cytoplasm (Pparg)
Anatomy Link Frequency
macrophages 3
colon 2
adipocyte 2
RAW 264 1
Pparg (Mus musculus)
Pain Link Frequency Relevance Heat
aspirin 3 100.00 Very High Very High Very High
COX2 1 100.00 Very High Very High Very High
cOX1 1 100.00 Very High Very High Very High
qutenza 28 99.98 Very High Very High Very High
Locus ceruleus 3 99.56 Very High Very High Very High
noradrenaline 8 99.36 Very High Very High Very High
Inflammation 15 95.32 Very High Very High Very High
Inflammatory mediators 2 91.16 High High
antagonist 4 84.88 Quite High
cINOD 5 82.72 Quite High
Disease Link Frequency Relevance Heat
Cancer 11 100.00 Very High Very High Very High
Necrosis 2 100.00 Very High Very High Very High
Disease 6 99.90 Very High Very High Very High
Death 1 99.78 Very High Very High Very High
Drug Induced Neurotoxicity 4 98.88 Very High Very High Very High
Colon Cancer 6 95.52 Very High Very High Very High
INFLAMMATION 19 95.32 Very High Very High Very High
Obesity 3 95.28 Very High Very High Very High
Body Weight 1 85.24 High High
Targeted Disruption 2 81.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conversely, decreased NA due to LC cell death in AD may reduce endogenous PPARgamma expression and therefore potentiate neuroinflammatory processes.
Negative_regulation (reduce) of Gene_expression (expression) of PPARgamma associated with locus ceruleus, noradrenaline, disease and death
1) Confidence 0.59 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12887689 Disease Relevance 0.72 Pain Relevance 0.74
Capsaicin inhibits the production of tumor necrosis factor alpha by LPS-stimulated murine macrophages, RAW 264.7: a PPARgamma ligand-like action as a novel mechanism.
Negative_regulation (inhibits) of in RAW 264 Gene_expression (production) of PPARgamma in macrophages associated with necrosis, qutenza and cancer
2) Confidence 0.41 Published 2004 Journal FEBS Lett. Section Title Doc Link 15304360 Disease Relevance 0.55 Pain Relevance 1.26
By using preadipocyte cultures, we found that evodiamine, but not capsaicin, increased phosphorylation of ERK/MAPK, reduced the expression of transcription factors such as peroxisome proliferator-activated receptor-gamma, and strongly inhibited adipocyte differentiation.
Negative_regulation (reduced) of Gene_expression (expression) of peroxisome proliferator-activated receptor-gamma in adipocyte associated with qutenza
3) Confidence 0.41 Published 2008 Journal Endocrinology Section Abstract Doc Link 17884939 Disease Relevance 0.40 Pain Relevance 0.17
Reduction of nuclear peroxisome proliferator-activated receptor gamma expression in methamphetamine-induced neurotoxicity and neuroprotective effects of ibuprofen.
Negative_regulation (Reduction) of Gene_expression (expression) of nuclear peroxisome proliferator-activated receptor gamma associated with aspirin and drug induced neurotoxicity
4) Confidence 0.14 Published 2009 Journal Neurochem. Res. Section Title Doc Link 18946735 Disease Relevance 0.32 Pain Relevance 0.32
Capsaicin inhibits the production of tumor necrosis factor alpha by LPS-stimulated murine macrophages, RAW 264.7: a PPARgamma ligand-like action as a novel mechanism.
Negative_regulation (inhibits) of Gene_expression (production) of PPARgamma in macrophages associated with necrosis, qutenza and cancer
5) Confidence 0.14 Published 2004 Journal FEBS Lett. Section Title Doc Link 15304360 Disease Relevance 0.55 Pain Relevance 1.26
Indomethacin reduced PGE2 content in normal and tumor tissue with subsequently decreased IP, HPGD and PPARgamma receptor expression in both tumor and normal colon tissue, while subtype EP1-4 receptors were not significantly influenced by indomethacin treatment.
Negative_regulation (decreased) of Gene_expression (expression) of PPARgamma in colon associated with cancer
6) Confidence 0.10 Published 2010 Journal Int. J. Oncol. Section Abstract Doc Link 20043083 Disease Relevance 1.18 Pain Relevance 0.20

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