INT112071

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Context Info
Confidence 0.62
First Reported 2003
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 4
Total Number 6
Disease Relevance 4.62
Pain Relevance 3.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pparg) signal transduction (Pparg) nucleus (Pparg)
enzyme binding (Pparg) DNA binding (Pparg) cytoplasm (Pparg)
Anatomy Link Frequency
fat 4
neurons 3
brain 2
astrocytes 1
Pparg (Mus musculus)
Pain Link Frequency Relevance Heat
noradrenaline 24 100.00 Very High Very High Very High
agonist 22 100.00 Very High Very High Very High
Inflammation 71 99.58 Very High Very High Very High
antagonist 6 94.84 High High
Locus ceruleus 9 90.92 High High
cINOD 7 82.68 Quite High
Inflammatory response 22 71.32 Quite High
Dismenorea 2 59.56 Quite High
Pain 2 57.52 Quite High
corticosteroid 14 19.52 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 99 99.58 Very High Very High Very High
Influenza Virus Infection 82 99.00 Very High Very High Very High
Diabetes Mellitus 5 98.40 Very High Very High Very High
Disease 23 94.92 High High
Hyperlipidemia 4 93.76 High High
Hyperinsulinism 2 93.00 High High
Body Weight 5 90.00 High High
Hyperglycemia 2 75.00 Quite High
Reprotox - General 1 2 59.56 Quite High
Thrombosis Related Under Development 2 58.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results indicate for the first time that PPARgamma expression can be modulated by the cAMP signalling pathway, and suggest that the anti-inflammatory effects of NA on brain cells may be partly mediated by increasing PPARgamma levels.
Regulation (modulated) of Gene_expression (expression) of PPARgamma in brain associated with inflammation and noradrenaline
1) Confidence 0.62 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12887689 Disease Relevance 0.75 Pain Relevance 0.86
To study a possible relationship between NA depletion and PPARgamma-mediated suppression of inflammation we investigated the influence of NA on PPARgamma expression in murine primary cortical astrocytes and neurons.
Spec (investigated) Regulation (influence) of Gene_expression (expression) of PPARgamma in neurons associated with inflammation and noradrenaline
2) Confidence 0.27 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12887689 Disease Relevance 0.91 Pain Relevance 0.87
While Aldridge and colleagues argue that PPAR-gamma agonists exert their effects during an influenza infection by down-regulating the recruitment of TNF-?
Regulation (exert) of Gene_expression (agonists) of PPAR-gamma associated with influenza virus infection and agonist
3) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2953496 Disease Relevance 0.66 Pain Relevance 0.25
EA exerted beneficial effects on glucose and lipid homeostasis in diabetes that are not secondary to its ability to decrease food intake but its specific effects on hepatic lipogenesis related genes (SREBPla, FAS, GAPT) and PPAR-gamma gene expression in periepididymal fat.
Regulation (effects) of Gene_expression (expression) of PPAR-gamma gene in fat associated with diabetes mellitus
4) Confidence 0.12 Published 2005 Journal J Ethnopharmacol Section Abstract Doc Link 16095853 Disease Relevance 0.70 Pain Relevance 0.12
EA exerted beneficial effects on glucose and lipid homeostasis in diabetes that are not secondary to its ability to decrease food intake but its specific effects on hepatic lipogenesis related genes (SREBPla, FAS, GAPT) and PPAR-gamma gene expression in periepididymal fat.
Regulation (effects) of Gene_expression (expression) of PPAR-gamma gene in fat associated with diabetes mellitus
5) Confidence 0.12 Published 2005 Journal J Ethnopharmacol Section Abstract Doc Link 16095853 Disease Relevance 0.70 Pain Relevance 0.12
To study a possible relationship between NA depletion and PPARgamma-mediated suppression of inflammation we investigated the influence of NA on PPARgamma expression in murine primary cortical astrocytes and neurons.
Spec (investigated) Regulation (influence) of in astrocytes Gene_expression (expression) of PPARgamma in neurons associated with inflammation and noradrenaline
6) Confidence 0.09 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12887689 Disease Relevance 0.91 Pain Relevance 0.87

General Comments

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