INT11208

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Context Info
Confidence 0.78
First Reported 1984
Last Reported 2009
Negated 0
Speculated 2
Reported most in Abstract
Documents 23
Total Number 46
Disease Relevance 2.42
Pain Relevance 11.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Cpe) extracellular space (Cpe) Golgi apparatus (Cpe)
Anatomy Link Frequency
brain 4
plasma 2
cleavage 2
BRL-3A 2
astrocytes 2
Cpe (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 60 100.00 Very High Very High Very High
headache 7 100.00 Very High Very High Very High
Opioid 2 100.00 Very High Very High Very High
Neurotransmitter 58 99.96 Very High Very High Very High
Cluster headache 7 99.72 Very High Very High Very High
Dynorphin 12 99.48 Very High Very High Very High
Dopamine 713 99.32 Very High Very High Very High
Neuropeptide 74 99.08 Very High Very High Very High
Pyramidal cell 10 98.68 Very High Very High Very High
Hippocampus 10 97.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Paroxysmal Hemicrania 5 100.00 Very High Very High Very High
Cluster Headache 7 99.72 Very High Very High Very High
Urological Neuroanatomy 4 99.48 Very High Very High Very High
Gliosis 5 99.04 Very High Very High Very High
Headache 2 99.00 Very High Very High Very High
INFLAMMATION 2 97.76 Very High Very High Very High
Pain 1 93.16 High High
Neurodegenerative Disease 4 89.80 High High
Alzheimer's Dementia 1 86.88 High High
Disease 70 79.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ibotenic acid lesions of the hippocampus eliminated the majority of the label, which had been present over pyramidal cells, though labeling was increased over areas of reactive gliosis, suggesting that activated astrocytes can also synthesize CPE mRNA.
Gene_expression (synthesize) of CPE mRNA in pyramidal cells associated with pyramidal cell, hippocampus and gliosis
1) Confidence 0.78 Published 1990 Journal J. Neurosci. Section Abstract Doc Link 2388090 Disease Relevance 0.10 Pain Relevance 0.45
Heterogeneous expression of carboxypeptidase E and proenkephalin mRNAs by cultured astrocytes.
Gene_expression (expression) of carboxypeptidase E in astrocytes associated with enkephalin
2) Confidence 0.77 Published 1992 Journal Brain Res. Section Title Doc Link 1540832 Disease Relevance 0.08 Pain Relevance 0.20
The percentage of cultured astrocytes expressing high levels of CPE mRNA was 42% for frontal cortex astrocytes and 23% for cerebellar astrocytes.
Gene_expression (expressing) of CPE mRNA in astrocytes associated with urological neuroanatomy
3) Confidence 0.77 Published 1992 Journal Brain Res. Section Abstract Doc Link 1540832 Disease Relevance 0.17 Pain Relevance 0.08
Carboxypeptidase E (CPE), also referred to as enkephalin convertase or carboxypeptidase H (EC 3.4.17.10), is present in neurotransmitter secretory granules and can remove C-terminal basic residues following endopeptidase cleavage during peptide processing.
Gene_expression (present) of CPE in cleavage associated with neurotransmitter and enkephalin
4) Confidence 0.68 Published 1990 Journal J. Neurosci. Section Abstract Doc Link 2388090 Disease Relevance 0 Pain Relevance 0.22
Carboxypeptidase E (CPE), also referred to as enkephalin convertase or carboxypeptidase H (EC 3.4.17.10), is present in neurotransmitter secretory granules and can remove C-terminal basic residues following endopeptidase cleavage during peptide processing.
Gene_expression (present) of Carboxypeptidase E in cleavage associated with neurotransmitter and enkephalin
5) Confidence 0.68 Published 1990 Journal J. Neurosci. Section Abstract Doc Link 2388090 Disease Relevance 0 Pain Relevance 0.22
In general, the localization of CPE mRNA in the rat brain corresponded to the distribution of enkephalin and other peptide neurotransmitter-synthesizing neurons, though CPE mRNA was also present in neurons that do not secrete known peptides and in reactive glia.
Gene_expression (present) of CPE mRNA in brain associated with neurotransmitter and enkephalin
6) Confidence 0.68 Published 1990 Journal J. Neurosci. Section Abstract Doc Link 2388090 Disease Relevance 0.09 Pain Relevance 0.44
The interval between indomethacin administration and clinical response may be extremely relevant in the assessment of chronic paroxysmal hemicrania (CPH) and other unilateral headache disorders like cluster headache (CH), with which CPH can be confounded.
Gene_expression (confounded) of CPH associated with cluster headache, headache and paroxysmal hemicrania
7) Confidence 0.66 Published 2003 Journal Cephalalgia Section Abstract Doc Link 12662186 Disease Relevance 0.93 Pain Relevance 0.93
In this study, the role of CPE as a sorting receptor for other RSP proteins that contain sorting signals (proinsulin, proenkephalin, and chromogranin A) was investigated in neuroendocrine cells (Neuro-2a) stably expressing CPE antisense RNA.
Gene_expression (expressing) of CPE in Neuro-2a
8) Confidence 0.61 Published 1998 Journal Endocrinology Section Abstract Doc Link 9529003 Disease Relevance 0 Pain Relevance 0
The highest levels of CPE mRNA were found to be present in the pyramidal cells of the hippocampus, the pituitary anterior and intermediate lobes, the ependymal cells of the lateral ventricle, the endopiriform nucleus, the basolateral amygdala, the supraoptic nucleus, and the paraventricular nucleus.
Gene_expression (levels) of CPE mRNA in lateral ventricle associated with pyramidal cell, hippocampus and amygdala
9) Confidence 0.60 Published 1990 Journal J. Neurosci. Section Abstract Doc Link 2388090 Disease Relevance 0 Pain Relevance 0.36
Differential ontogeny of rat brain peptidases: prenatal expression of enkephalin convertase and postnatal development of angiotensin-converting enzyme.
Gene_expression (expression) of enkephalin convertase in brain associated with enkephalin
10) Confidence 0.57 Published 1986 Journal Brain Res. Section Title Doc Link 3021286 Disease Relevance 0 Pain Relevance 0.52
The expression of enkephalin convertase prior to that of most neuropeptides supports a role for this enzyme in propeptide processing.
Gene_expression (expression) of enkephalin convertase associated with neuropeptide and enkephalin
11) Confidence 0.57 Published 1986 Journal Brain Res. Section Abstract Doc Link 3021286 Disease Relevance 0 Pain Relevance 0.55
Enkephalin convertase (EC 3.4.17.10), a carboxypeptidase B-like enzyme detected by [3H]guanidinoethylmercaptosuccinic acid (GEMSA) autoradiography, is present in high concentration throughout the brains of rat fetuses 3 days prior to birth.
Gene_expression (present) of Enkephalin convertase in brains associated with enkephalin
12) Confidence 0.57 Published 1986 Journal Brain Res. Section Abstract Doc Link 3021286 Disease Relevance 0 Pain Relevance 0.44
In virtually all cells coexpressing DAT and CPE, DAT was largely found at the plasma membrane and colocalized with CPE (Fig. 3C).
Gene_expression (coexpressing) of CPE in plasma
13) Confidence 0.47 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.03
Since no change in DA uptake affinity could be observed upon coexpression of CPE with DAT, the increase in Vmax may reflect a change in the population of cell surface DAT.
Gene_expression (coexpression) of CPE associated with dopamine
14) Confidence 0.47 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.21
In addition, immunofluorescence analysis demonstrated that co-expression of CPE and DAT facilitated surface translocation of both proteins.
Gene_expression (expression) of CPE
15) Confidence 0.47 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.18
Taken together, these data indicated that the binding of DAT-CT tail583–620 sequences to CPE was both sufficient and necessary for the expression of CPE- mediated functional regulation of the DA translocation process.


Gene_expression (expression) of CPE associated with dopamine
16) Confidence 0.47 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.25
As illustrated in Fig 2A, CPE coexpression significantly increased the maximal uptake velocity (Vmax) of [3H] DA by ~50% (DAT: Vmax = 10.8 ± 1 pmol/min/well; DAT+CPE: 16 ± 1.9 pmol/min/well; P < 0.01), whereas no significant change in the estimated Km of the DAT could be observed (DAT: Km = 6.6 ± 0.7 ?
Gene_expression (coexpression) of CPE associated with dopamine
17) Confidence 0.47 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.17
Therefore, we next examined if DAT cell surface expression levels change upon coexpression of CPE by using a cell-based ELISA assay to quantify changes at the cell surface and total DAT levels [27-29].
Spec (examined) Gene_expression (expression) of CPE
18) Confidence 0.47 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.20
However, coexpression of CPE inhibited the disappearance of the DAT-positive band at 12 hours but was still completely degraded at 24 hours.


Gene_expression (coexpression) of CPE in band
19) Confidence 0.47 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.07
The expression of carboxypeptidase E, furin, and dynorphin converting enzyme in BRL-3A cells suggests that these peptide processing enzymes are not specific for neuropeptides, but are also present in cells which process peptide growth factors.
Gene_expression (expression) of carboxypeptidase E in BRL-3A associated with dynorphin and neuropeptide
20) Confidence 0.46 Published 1993 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 8375574 Disease Relevance 0 Pain Relevance 0.30

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