INT112081

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Context Info
Confidence 0.34
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 2.37
Pain Relevance 1.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Vsig2) biological_process (Vsig2)
Anatomy Link Frequency
joint 1
articular 1
neurons 1
Vsig2 (Mus musculus)
Pain Link Frequency Relevance Heat
conotoxin 2 99.84 Very High Very High Very High
antinociception 5 99.40 Very High Very High Very High
Calcium channel 1 98.68 Very High Very High Very High
Osteoarthritis 149 98.32 Very High Very High Very High
Analgesic 10 94.80 High High
tail-flick 4 91.68 High High
ischemia 1 87.76 High High
Pain 38 75.28 Quite High
Arthritis 5 74.52 Quite High
intrathecal 1 65.84 Quite High
Disease Link Frequency Relevance Heat
Stress 6 98.44 Very High Very High Very High
Knee Osteoarthritis 90 98.32 Very High Very High Very High
Hypercalcemia 22 96.60 Very High Very High Very High
Osteoarthritis 61 94.00 High High
Cv Unclassified Under Development 1 87.76 High High
Toxicity 32 78.96 Quite High
Rheumatoid Arthritis 2 75.44 Quite High
Pain 36 75.28 Quite High
Bordatella Infection 2 75.00 Quite High
Vibrio Infection 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, inactivation of supraspinally located PTX-sensitive G-proteins and spinally located CTX-sensitive G-proteins may modulate immobilization stress-induced antinociception.
Negative_regulation (inactivation) of CTX associated with stress and antinociception
1) Confidence 0.34 Published 2003 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 12888188 Disease Relevance 0.65 Pain Relevance 0.65
The quantitative estimation of equivalents of CTX in samples may be obtained using the substitution of the concentration of standard material that induced 50% of effects for the concentration of sample that induced 50% of effects [119].
Negative_regulation (equivalents) of CTX
2) Confidence 0.24 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2901828 Disease Relevance 0.14 Pain Relevance 0
Contrary to our initial hypothesis that CTX-II levels should decrease after intra-articular hyaluronic acid injections, we found a significant increase in urinary CTX-II levels that was sustained throughout the study.
Negative_regulation (decrease) of CTX-II in articular
3) Confidence 0.06 Published 2010 Journal Clin. Rheumatol. Section Abstract Doc Link 20101426 Disease Relevance 0.51 Pain Relevance 0.32
omega-Conotoxin MVIIA (CTX MVIIA) is a potent and selective blocker of the N-type voltage-sensitive calcium channel in neurons.
Negative_regulation (blocker) of CTX MVIIA in neurons associated with calcium channel and conotoxin
4) Confidence 0.05 Published 2003 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 14592443 Disease Relevance 0.09 Pain Relevance 0.43
In 6-month-old rats, the CTX-II levels decreased by 86% compared to 3-month-old rats (Fig. 1), suggesting that skeletal growth and thereby growth-plate turnover at this time are minimized.
Negative_regulation (decreased) of CTX-II
5) Confidence 0.01 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400436 Disease Relevance 0 Pain Relevance 0
In contrast, the lower dose of SERM was only partly effective in reducing the elevated CTX-II levels.
Negative_regulation (reducing) of CTX-II
6) Confidence 0.01 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400436 Disease Relevance 0.37 Pain Relevance 0.04
At 12 and 24 weeks, significant reductions in urinary CTX-II and MMP-3, but not NTX concentrations, were observed for adalimumab versus placebo (p<0.001).
Negative_regulation (reductions) of CTX-II
7) Confidence 0.01 Published 2008 Journal J. Rheumatol. Section Body Doc Link 18785308 Disease Relevance 0.07 Pain Relevance 0
At 1 year, treatment with risedronate at 15 mg significantly decreased mean urinary CTX-II values, by -22.8% ± 5.35; urinary NTX-I was reduced by -32.9% ± 4.92 relative to baseline values (P < 0.05).
Negative_regulation (decreased) of CTX-II
8) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174954 Disease Relevance 0.24 Pain Relevance 0.14
Both studies showed significant decreases in CTX-II, the marker of cartilage degradation, but these were not associated with an attenuation of joint-space loss This lack of association may be related to the length of observation in these studies.
Negative_regulation (decreases) of CTX-II in joint
9) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174954 Disease Relevance 0.31 Pain Relevance 0.12

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