INT112088

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Context Info
Confidence 0.44
First Reported 2003
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.51
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cav1) mitochondrion (Cav1) Golgi apparatus (Cav1)
endoplasmic reticulum (Cav1) intracellular (Cav1) protein complex (Cav1)
Cav1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nav1.7 1 98.60 Very High Very High Very High
nav1.8 1 98.16 Very High Very High Very High
Pain 5 96.52 Very High Very High Very High
Calcium channel 3 95.36 Very High Very High Very High
Analgesic 2 75.00 Quite High
analgesia 2 74.32 Quite High
Morphine 1 66.40 Quite High
nMDA receptor 4 55.04 Quite High
long-term potentiation 3 48.32 Quite Low
Hippocampus 1 44.16 Quite Low
Disease Link Frequency Relevance Heat
Nociception 1 96.64 Very High Very High Very High
Pain 5 96.52 Very High Very High Very High
Cancer 56 90.20 High High
Targeted Disruption 6 86.24 High High
Body Weight 1 73.68 Quite High
Colon Cancer 33 50.00 Quite Low
INFLAMMATION 17 5.00 Very Low Very Low Very Low
Apoptosis 8 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 5 5.00 Very Low Very Low Very Low
Adenocarcinoma 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To investigate this we have examined the effect of disrupting the gene encoding the CaV1.3 (alpha 1D) alpha subunit of L-type Ca2+ channels on neurological function, acute nociceptive behavior, and hippocampal synaptic function in mice.
Spec (examined) Regulation (effect) of CaV1 associated with nociception
1) Confidence 0.44 Published 2003 Journal Neuroscience Section Abstract Doc Link 12890513 Disease Relevance 0.35 Pain Relevance 0.17
In contrast, lipoamino acids had weak effects on high-voltage-activated (HVA) Cav1.2 and Cav2.2 calcium currents, on Nav1.7 and Nav1.8 sodium currents, and on anandamide-sensitive TRPV1 and TASK1 currents.
Regulation (effects) of Cav1 associated with nav1.8 and nav1.7
2) Confidence 0.31 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19846698 Disease Relevance 0.06 Pain Relevance 0.56
While the effect of statins on caveolae disruption and caveolin-1 function may be related to its ability to block cholesterol formation, the effect of statins on proteins like lamin B, Ras and Rho is due to the unavailability of cholesterol biosynthetic pathway intermediates called isorenoids.
Regulation (effect) of caveolin-1
3) Confidence 0.20 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2745153 Disease Relevance 0.09 Pain Relevance 0

General Comments

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