INT112090

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Context Info
Confidence 0.57
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 3.50
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cav1) mitochondrion (Cav1) Golgi apparatus (Cav1)
endoplasmic reticulum (Cav1) intracellular (Cav1) protein complex (Cav1)
Anatomy Link Frequency
macrophages 2
Cav1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 16 97.36 Very High Very High Very High
nMDA receptor 14 96.76 Very High Very High Very High
cINOD 8 95.84 Very High Very High Very High
long-term potentiation 7 95.72 Very High Very High Very High
anesthesia 4 85.72 High High
Hippocampus 3 82.56 Quite High
agonist 24 68.32 Quite High
adenocard 2 67.28 Quite High
amygdala 2 59.48 Quite High
halothane 2 55.24 Quite High
Disease Link Frequency Relevance Heat
Breast Cancer 138 98.36 Very High Very High Very High
INFLAMMATION 62 94.40 High High
Hypokalemic Periodic Paralysis 58 93.44 High High
Cancer 212 91.00 High High
Injury 20 90.72 High High
Disease 90 89.44 High High
Toxicity 24 87.96 High High
Malignant Hyperthermia 16 86.16 High High
Renal Failure 2 80.16 Quite High
Myoglobinuria 2 78.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together these data indicate that following loss of CaV1.3 alpha 1 subunit expression there is sufficient residual activity of other Ca2+ channel subtypes to support NMDA receptor-independent long-term potentiation and some forms of sensory behavior/function.
Negative_regulation (loss) of Gene_expression (expression) of CaV1 associated with nmda receptor and long-term potentiation
1) Confidence 0.57 Published 2003 Journal Neuroscience Section Abstract Doc Link 12890513 Disease Relevance 0.19 Pain Relevance 0.34
To establish whether interactions between maxi-K channels and caveolin affect the endogenous myometrial total outward K+ current, we used a siRNA to inhibit cav-1 gene expression in hMSMCs.
Negative_regulation (inhibit) of Gene_expression (expression) of cav-1 gene
2) Confidence 0.45 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2785819 Disease Relevance 0 Pain Relevance 0
Although reduced expression of Cav1.1, ?
Negative_regulation (reduced) of Gene_expression (expression) of Cav1
3) Confidence 0.34 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2883925 Disease Relevance 0.40 Pain Relevance 0.12
Several alternative loci have also been proposed, but so far, only the Cav1.1 ?
Negative_regulation (loci) of Spec (proposed) Gene_expression (proposed) of Cav1
4) Confidence 0.34 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2883925 Disease Relevance 0.84 Pain Relevance 0.15
The maxi-K channel-generated current in human MSMCs is reduced when caveolin-1 is knocked down
Negative_regulation (down) of Gene_expression (knocked) of caveolin-1
5) Confidence 0.33 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2785819 Disease Relevance 0 Pain Relevance 0
Caveolin-1 expression is reduced in early mammary carcinogenesis [9], but increased levels have been found in many basal-like breast cancers [10].
Negative_regulation (reduced) of Gene_expression (expression) of Caveolin-1 associated with breast cancer
6) Confidence 0.20 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 0.93 Pain Relevance 0
In MDA-MB231 cell, CDIM9 induced caveolin-1 and p27 expression, which was significantly downregulated by co-treatment with the PPAR-?
Negative_regulation (downregulated) of Gene_expression (expression) of caveolin-1
7) Confidence 0.15 Published 2007 Journal Breast Cancer Res Section Abstract Doc Link PMC2206732 Disease Relevance 0.87 Pain Relevance 0.18
Treatment of mice with ozone caused an immediate decrease in Cav-1 expression that began to return to control at 12 h.
Negative_regulation (decrease) of Gene_expression (expression) of Cav-1
8) Confidence 0.13 Published 2009 Journal Toxicological Sciences Section Body Doc Link PMC2769059 Disease Relevance 0.06 Pain Relevance 0
was effective in suppressing Cav-1 expression in macrophages in culture.
Negative_regulation (suppressing) of Gene_expression (expression) of Cav-1 in macrophages
9) Confidence 0.09 Published 2009 Journal Toxicological Sciences Section Body Doc Link PMC2769059 Disease Relevance 0.20 Pain Relevance 0

General Comments

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