INT112100

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Context Info
Confidence 0.42
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.71
Pain Relevance 4.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grin2b) plasma membrane (Grin2b) embryo development (Grin2b)
Anatomy Link Frequency
dorsal horn 3
amygdala 2
forebrain 1
Grin2b (Mus musculus)
Pain Link Frequency Relevance Heat
Central grey 77 99.68 Very High Very High Very High
amygdala 12 99.68 Very High Very High Very High
Analgesic 67 99.28 Very High Very High Very High
nMDA receptor 105 99.24 Very High Very High Very High
Inflammation 27 98.72 Very High Very High Very High
Dorsal horn 26 98.20 Very High Very High Very High
IPN 13 95.52 Very High Very High Very High
spinal dorsal horn 1 95.00 High High
Central nervous system 29 87.04 High High
antagonist 37 86.24 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 77 99.68 Very High Very High Very High
Targeted Disruption 111 99.60 Very High Very High Very High
Anxiety Disorder 23 99.12 Very High Very High Very High
INFLAMMATION 30 98.72 Very High Very High Very High
Inflammatory Pain 13 95.52 Very High Very High Very High
Injury 27 92.56 High High
Pain 96 83.48 Quite High
Nervous System Injury 8 77.12 Quite High
Nociception 14 70.24 Quite High
Substance Withdrawal Syndrome 9 67.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The down regulation of NR2B expression throughout development is marked by a concomitant change in NMDA receptor function [13].
Negative_regulation (regulation) of Gene_expression (expression) of NR2B associated with nmda receptor
1) Confidence 0.42 Published 2008 Journal Mol Brain Section Body Doc Link PMC2546399 Disease Relevance 0.44 Pain Relevance 1.64
However, PSD-93 deletion significantly reduced the levels of NR2A and NR2B in the synaptosomal membrane fractions from dorsal horn and forebrain cortex, but not cerebellum, of mice (Fig. 1B).
Negative_regulation (reduced) of Gene_expression (levels) of NR2B in dorsal horn associated with dorsal horn
2) Confidence 0.39 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 0.23 Pain Relevance 0.22
Western blots show a reduction in phosphorylated-NR1, NR2A, and NR2B subunit protein expression in the amygdala from fear-conditioned animals.
Negative_regulation (reduction) of Gene_expression (expression) of NR2B in amygdala associated with anxiety disorder and amygdala
3) Confidence 0.39 Published 2009 Journal Mol Brain Section Body Doc Link PMC2644299 Disease Relevance 0.77 Pain Relevance 0.68
Targeted disruption of the PSD-93 gene reduces not only surface NR2A and NR2B expression but also NMDAR-mediated excitatory postsynaptic currents and potentials, without affecting surface AMPA receptor expression or its synaptic function, in the regions mentioned above.
Negative_regulation (reduces) of Gene_expression (expression) of NR2B associated with targeted disruption
4) Confidence 0.36 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12890763 Disease Relevance 0.48 Pain Relevance 0.56
NR2B expression was significantly reduced in the PAG of CFA-injected mice administrated with Hyp (100 mg/kg, i.g. twice daily for 3 days) (132.1% ± 26.8% saline, n = 6, p < 0.05 vs CFA-injected alone; Fig. 1B).
Negative_regulation (reduced) of Gene_expression (expression) of NR2B associated with central grey
5) Confidence 0.30 Published 2009 Journal Mol Pain Section Body Doc Link PMC2803476 Disease Relevance 1.56 Pain Relevance 0.92
However, PSD-93 deletion significantly reduced the levels of NR2A and NR2B in the synaptosomal membrane fractions from dorsal horn and forebrain cortex, but not cerebellum, of mice (Fig. 1B).
Negative_regulation (reduced) of in forebrain Gene_expression (levels) of NR2B in dorsal horn associated with dorsal horn
6) Confidence 0.13 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 0.23 Pain Relevance 0.22

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