INT112101

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Context Info
Confidence 0.73
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 5.06
Pain Relevance 6.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Dlg2) cytoplasm (Dlg2)
Anatomy Link Frequency
dorsal horn 3
forebrain 2
synapse 1
Dlg2 (Mus musculus)
Pain Link Frequency Relevance Heat
narcan 24 99.84 Very High Very High Very High
spinal dorsal horn 4 99.40 Very High Very High Very High
Dorsal horn 48 99.20 Very High Very High Very High
withdrawal 92 99.16 Very High Very High Very High
Spinal cord 32 98.60 Very High Very High Very High
Morphine 308 98.28 Very High Very High Very High
Physical dependence 60 98.24 Very High Very High Very High
Central nervous system 51 98.04 Very High Very High Very High
tolerance 100 97.76 Very High Very High Very High
Lasting pain 48 97.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Substance Withdrawal Syndrome 16 99.16 Very High Very High Very High
Targeted Disruption 286 98.72 Very High Very High Very High
Drug Dependence 60 98.24 Very High Very High Very High
Aids-related Complex 1 97.52 Very High Very High Very High
Pain 92 97.32 Very High Very High Very High
Death 10 92.32 High High
Stress 24 91.56 High High
Nervous System Malformation 8 76.88 Quite High
INFLAMMATION 15 68.36 Quite High
Nervous System Injury 8 60.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We report here that postsynaptic density-93 protein (PSD-93), a postsynaptic neuronal MAGUK, is expressed abundantly in spinal dorsal horn and forebrain, where it colocalizes and interacts with NMDAR subunits NR2A and NR2B.
Gene_expression (expressed) of postsynaptic density-93 protein in forebrain associated with spinal dorsal horn
1) Confidence 0.73 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12890763 Disease Relevance 0.44 Pain Relevance 0.48
We report here that postsynaptic density-93 protein (PSD-93), a postsynaptic neuronal MAGUK, is expressed abundantly in spinal dorsal horn and forebrain, where it colocalizes and interacts with NMDAR subunits NR2A and NR2B.
Gene_expression (expressed) of PSD-93 in forebrain associated with spinal dorsal horn
2) Confidence 0.73 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12890763 Disease Relevance 0.43 Pain Relevance 0.48
Our previous studies demonstrated that PSD-93, NR2A, and NR2B are highly expressed in the superficial dorsal horn of spinal cord [16].
Gene_expression (expressed) of PSD-93 in dorsal horn associated with dorsal horn and spinal cord
3) Confidence 0.53 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 0.31 Pain Relevance 0.62
Given that inhibition of nNOS attenuates the development of persistent pain and morphine analgesic tolerance and physical dependence [34,35], it is very likely that the dissociation of NMDARs from NO signaling caused by PSD-93 deletion is also involved in the mechanism underlying impairing persistent pain and morphine analgesic tolerance and physical dependence in the KO mice.
Gene_expression (deletion) of PSD-93 associated with targeted disruption, pain, physical dependence, analgesic, lasting pain, tolerance and morphine
4) Confidence 0.52 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 1.10 Pain Relevance 1.46
In conclusion, the present study was the first to demonstrate that PSD-93 deletion has distinct effects on synaptic NMDAR expression in the CNS.
Gene_expression (deletion) of PSD-93 associated with central nervous system
5) Confidence 0.52 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 0.78 Pain Relevance 1.28
Effect of PSD-93 deletion on naloxone-induced withdrawal symptoms
Gene_expression (deletion) of PSD-93 associated with narcan and withdrawal
6) Confidence 0.52 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 0.70 Pain Relevance 0.94
The observed increases in gene expression for the synaptic membrane scaffold proteins (Dlg1, Dlg2, and Dlg4), and a protein involved in synapse strengthening (Arc, Activity-Regulated Cytoskeleton-Associated Protein), also fit a pattern of new synapse growth.
Gene_expression (expression) of Dlg2 in synapse associated with aids-related complex
7) Confidence 0.45 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.42 Pain Relevance 0.28
We report here that postsynaptic density-93 protein (PSD-93), a postsynaptic neuronal MAGUK, is expressed abundantly in spinal dorsal horn and forebrain, where it colocalizes and interacts with NMDAR subunits NR2A and NR2B.
Gene_expression (expressed) of postsynaptic density-93 protein in dorsal horn associated with spinal dorsal horn
8) Confidence 0.25 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12890763 Disease Relevance 0.44 Pain Relevance 0.48
We report here that postsynaptic density-93 protein (PSD-93), a postsynaptic neuronal MAGUK, is expressed abundantly in spinal dorsal horn and forebrain, where it colocalizes and interacts with NMDAR subunits NR2A and NR2B.
Gene_expression (expressed) of PSD-93 in dorsal horn associated with spinal dorsal horn
9) Confidence 0.25 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12890763 Disease Relevance 0.43 Pain Relevance 0.48

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