INT112102

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Context Info
Confidence 0.55
First Reported 2001
Last Reported 2010
Negated 6
Speculated 0
Reported most in Body
Documents 14
Total Number 16
Disease Relevance 5.40
Pain Relevance 5.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gria2) endoplasmic reticulum (Gria2) plasma membrane (Gria2)
protein complex (Gria2)
Anatomy Link Frequency
spinal 4
dorsal horn 4
hippocampus 4
neurons 2
amygdala 2
Gria2 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate receptor 85 100.00 Very High Very High Very High
antidepressant 6 100.00 Very High Very High Very High
spinal dorsal horn 30 99.84 Very High Very High Very High
Inflammation 40 99.82 Very High Very High Very High
Hippocampus 153 99.68 Very High Very High Very High
amygdala 7 99.68 Very High Very High Very High
IPN 37 98.84 Very High Very High Very High
Glutamate 50 98.80 Very High Very High Very High
Central nervous system 58 98.16 Very High Very High Very High
Desipramine 1 97.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 41 99.82 Very High Very High Very High
Thiamine Deficiency 186 99.80 Very High Very High Very High
Nociception 108 99.44 Very High Very High Very High
Inflammatory Pain 37 98.84 Very High Very High Very High
Toxicity 3 97.12 Very High Very High Very High
Targeted Disruption 59 96.98 Very High Very High Very High
Neuropathic Pain 21 92.32 High High
Motor Neuron Diseases 14 91.28 High High
Disease 35 89.84 High High
Neurological Disease 7 89.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In an animal model of complete Freund's adjuvant (CFA)-induced persistent inflammatory pain, Park et al. found that CFA-induced inflammation did not change the total expression or distribution of AMPA receptor subunits, GluR1 and GluR2 in spinal dorsal horn, but did alter their subcellular distribution.
Neg (not) Regulation (change) of Gene_expression (expression) of GluR2 in dorsal horn associated with inflammation, spinal dorsal horn and ipn
1) Confidence 0.55 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.45 Pain Relevance 0.58
We also noted no difference in expression of GluR2 in the amygdala between GluR2-cKO mice and controls.
Neg (no) Regulation (difference) of Gene_expression (expression) of GluR2 in amygdala associated with amygdala
2) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947514 Disease Relevance 0.05 Pain Relevance 0.28
Functional regulation of spinal AMPA receptors through phosphorylation of receptor subunits
Regulation (regulation) of Gene_expression (receptors) of AMPA in spinal
3) Confidence 0.40 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.41 Pain Relevance 0.40
In an animal model of complete Freund's adjuvant (CFA)-induced persistent inflammatory pain, Park et al. found that CFA-induced inflammation did not change the total expression or distribution of AMPA receptor subunits, GluR1 and GluR2 in spinal dorsal horn, but did alter their subcellular distribution.
Neg (not) Regulation (change) of Gene_expression (expression) of AMPA receptor in dorsal horn associated with inflammation, spinal dorsal horn and ipn
4) Confidence 0.40 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.45 Pain Relevance 0.58
Regulation of the spinal AMPA receptors in post-synaptic membrane through the receptor trafficking evoked by painful stimuli
Regulation (Regulation) of Gene_expression (receptors) of AMPA in spinal associated with pain
5) Confidence 0.40 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.09 Pain Relevance 0.48
We demonstrate that TD does not affect GluR2 expression, but inhibits its RNA editing.
Neg (not) Regulation (affect) of Gene_expression (expression) of GluR2 associated with thiamine deficiency
6) Confidence 0.38 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3006372 Disease Relevance 1.18 Pain Relevance 0.14
Altered GluR2 gene expression does not affect cell survival
Regulation (Altered) of Gene_expression (expression) of GluR2
7) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947514 Disease Relevance 0 Pain Relevance 0.26
In their studies of the hippocampus in mice with reduced or deleted GluR2 sub-units, they demonstrated that GluR2 sub-units play a critical role in the assembly and synaptic expression of the AMPA receptor complex.
Regulation (role) of Gene_expression (expression) of AMPA receptor in hippocampus associated with hippocampus
8) Confidence 0.25 Published 2004 Journal BMC Med Genet Section Body Doc Link PMC411038 Disease Relevance 0.14 Pain Relevance 0.29
Manipulation of ADAR2 expression alters AMPA-mediated Ca2+ influx and TD-induced cytoxicity
Regulation (Manipulation) of Gene_expression (influx) of AMPA-mediated associated with thiamine deficiency
9) Confidence 0.24 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3006372 Disease Relevance 0.76 Pain Relevance 0
These changes arise not only from dysregulation of the expression of GluR2, but also because of RNA editing [50] and receptor trafficking [51].
Regulation (dysregulation) of Gene_expression (expression) of GluR2
10) Confidence 0.17 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3006372 Disease Relevance 1.11 Pain Relevance 0.16
Targeted disruption of the PSD-93 gene reduces not only surface NR2A and NR2B expression but also NMDAR-mediated excitatory postsynaptic currents and potentials, without affecting surface AMPA receptor expression or its synaptic function, in the regions mentioned above.
Neg (without) Regulation (affecting) of Gene_expression (expression) of AMPA receptor associated with targeted disruption
11) Confidence 0.10 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12890763 Disease Relevance 0.51 Pain Relevance 0.59
Moreover, the basal expression of growth factor brain-derived neurotrophic factor and subunit 1 of AMPA glutamate receptor, GluR1, both of which are modified after chronic antidepressant administration, are altered in the hippocampus of CN98 mice.
Regulation (altered) of Gene_expression (expression) of AMPA glutamate receptor in hippocampus associated with antidepressant, glutamate receptor and hippocampus
12) Confidence 0.09 Published 2007 Journal Neuroscience Section Abstract Doc Link 17207580 Disease Relevance 0.09 Pain Relevance 0.67
Normal AMPA receptor function in TgDREAM mice
Regulation (Normal) of Gene_expression (function) of AMPA receptor
13) Confidence 0.06 Published 2010 Journal Mol Brain Section Body Doc Link PMC2822766 Disease Relevance 0 Pain Relevance 0.20
However, the application of D-AP5 did indeed affect the amplitude of the dual component EPSC as well as the initial slope indicating that these parameters were clearly not exclusively mediated by AMPA receptor activation under our experimental conditions.
Neg (not) Regulation (mediated) of Gene_expression (activation) of AMPA receptor
14) Confidence 0.04 Published 2008 Journal J Neural Transm Section Body Doc Link PMC2516544 Disease Relevance 0 Pain Relevance 0.21
In contrast to previous observations that the AMPA receptor expression is relatively constant in glutamate sensitive neurons [26], recent studies have shown that the expression of AMPA receptor subunits, especially GluR1, the major functional subunit of the AMPA receptor [11] is regulated developmentally at regional, cellular, and synaptic levels [27,28,29,30].
Regulation (regulated) of Gene_expression (expression) of AMPA in neurons associated with glutamate
15) Confidence 0.03 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0.06 Pain Relevance 0.32
Transcriptional regulation of metabotropic glutamate receptor 2/3 expression by the NF-?
Regulation (regulation) of Gene_expression (expression) of glutamate receptor 2 associated with glutamate receptor
16) Confidence 0.02 Published 2006 Journal Mol Pain Section Title Doc Link PMC1550235 Disease Relevance 0.09 Pain Relevance 0.37

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