INT112103

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Context Info
Confidence 0.48
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 28
Total Number 28
Disease Relevance 4.21
Pain Relevance 12.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grin1) plasma membrane (Grin1) enzyme binding (Grin1)
cytoplasm (Grin1)
Anatomy Link Frequency
postsynaptic membrane 1
anterior 1
brain 1
forebrain 1
vestibule 1
Grin1 (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 262 100.00 Very High Very High Very High
Glutamate receptor 48 100.00 Very High Very High Very High
agonist 14 100.00 Very High Very High Very High
opioid receptor 168 99.90 Very High Very High Very High
Neurotransmitter 34 99.80 Very High Very High Very High
Hippocampus 162 99.76 Very High Very High Very High
tolerance 95 99.64 Very High Very High Very High
tetrodotoxin 11 99.58 Very High Very High Very High
Thalamus 40 99.40 Very High Very High Very High
spinal dorsal horn 3 99.18 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 119 99.40 Very High Very High Very High
Drug Dependence 24 99.00 Very High Very High Very High
Neuropathic Pain 8 97.80 Very High Very High Very High
Pain 46 96.72 Very High Very High Very High
Systemic Lupus Erythematosus 84 93.48 High High
Urological Neuroanatomy 37 91.00 High High
Hypersensitivity 10 86.92 High High
Repression 68 85.52 High High
Nervous System Injury 7 77.96 Quite High
Alcohol Addiction 50 69.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data provide important insights into the cascade of events involving the dynamic interaction between NMDAR function and spinal chemokine and glial production in neuropathic pain states.
NMDAR Binding (interaction) of in spinal associated with chemokine and neuropathic pain
1) Confidence 0.48 Published 2004 Journal Neuroscience Section Abstract Doc Link 15051165 Disease Relevance 0.77 Pain Relevance 0.87
Unexpectedly, mutant mice were also more resistant to pentobarbital, which is thought not to interact with NMDAR at clinically relevant concentrations.
NMDAR Binding (interact) of
2) Confidence 0.48 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15385364 Disease Relevance 0.09 Pain Relevance 0.45
These results indicate that the Neto1:NMDAR extracellular interaction is dependent on the first CUB domain of Neto1.


NMDAR Binding (interaction) of
3) Confidence 0.36 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0
We next asked which NMDAR subunit mediates the Neto1:NMDAR interaction, using heterologously expressed proteins in HEK293 cells.
NMDAR Binding (interaction) of
4) Confidence 0.36 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0
NR1 subunits bind the co-agonist glycine and NR2 subunits bind the neurotransmitter glutamate.
NR1 Binding (bind) of associated with glutamate, neurotransmitter and agonist
5) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797636 Disease Relevance 0 Pain Relevance 0.89
Since ifenprodil is well accepted for its selectivity on NR2B NMDARs, whereas NVP on NR2A is a debate, we therefore employed the occlusion strategy to test NR2B component with or without pretreatment with NVP.
NMDAR Binding (selectivity) of
6) Confidence 0.36 Published 2007 Journal Mol Pain Section Body Doc Link PMC1871573 Disease Relevance 0 Pain Relevance 0.23
Besides NMDARs and nNOS, PSD-93 binds to other postsynaptic membrane proteins, such as potassium channels [9,10], ?
NMDAR Binding (binds) of in postsynaptic membrane associated with potassium channel
7) Confidence 0.35 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 0.98 Pain Relevance 1.43
NMDARs are heteromeric assemblies of NR1, NR2 and NR3 subunits, which co-translationally assemble in the endoplasmic reticulum to form functional channels.
NR1 Binding (assemblies) of in reticulum
8) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797636 Disease Relevance 0 Pain Relevance 0.86
NR1 expression is not altered in the dark-reared visual cortex [24,25] but contrarily, an intraocular injection of tetrodotoxin (TTX) does increase NR1-antibody binding in layer IV of the cortical column driven by the blocked eye [41].
NR1 Binding (binding) of in eye associated with tetrodotoxin
9) Confidence 0.31 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0 Pain Relevance 0.15
We report here that postsynaptic density-93 protein (PSD-93), a postsynaptic neuronal MAGUK, is expressed abundantly in spinal dorsal horn and forebrain, where it colocalizes and interacts with NMDAR subunits NR2A and NR2B.
NMDAR Binding (interacts) of in forebrain associated with spinal dorsal horn
10) Confidence 0.29 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12890763 Disease Relevance 0.46 Pain Relevance 0.49
The simplest model consistent with our findings is that Neto1 interacts with the NMDAR bivalently, with one Neto1:NMDAR interaction mediated through the binding of the C-terminal tripeptide of Neto1 to PSD-95, and the second through the extracellular domains of Neto1 and NR2 subunits.


NMDAR Binding (interaction) of
11) Confidence 0.28 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0
20HA co-immunoprecipitated with both NR1 and NR2B, even in the absence of PSD-95 (Figure 4A, lane 2 and 3, respectively).
NR1 Binding (immunoprecipitated) of
12) Confidence 0.28 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.04
Consequently, we conclude that the PSD-95-independent Neto1:NMDAR interaction is mediated through NR2 subunits, and that the first extracellular CUB domain of Neto1 is sufficient for this binding.
NMDAR Binding (interaction) of
13) Confidence 0.28 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0
An emerging theme in NMDAR biology is that proteins associated with the core NMDAR may have important roles in the trafficking, stability, subunit composition, or function of NMDARs and may therefore be critical for synaptic plasticity, learning, and memory [5].
NMDAR Binding (associated) of
14) Confidence 0.27 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.19
NR1 subunits bind the co-agonist glycine and NR2 subunits bind the neurotransmitter glutamate.
NR1 Binding (bind) of associated with glutamate, neurotransmitter and agonist
15) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797636 Disease Relevance 0 Pain Relevance 0.90
Moreover, at the ultrastructural level, both receptors show co-localization [76], suggesting that MOR and NMDAR could physically interact in the manner described for GPCRs such as D1, mGlu5a and the NR1 subunit of the NMDAR [77]–[79].
NMDAR Binding (interact) of associated with opioid receptor
16) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.09 Pain Relevance 1.07
Upon inhibition of these early processes (e.g., Akt or nNOS), the subsequent steps responsible for NMDAR sustained potentiation and MOR tolerance do not occur.
NMDAR Binding (potentiation) of associated with tolerance and opioid receptor
17) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 1.13
The ability of [3H]dextrorphan to bind to a closed channel, moreover, indicates that its recognition site is shallower in the ion channel domain than that of MK-801 and may be associated with the extracellular vestibule of the NMDAR.
NMDAR Binding (associated) of in vestibule
18) Confidence 0.19 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15992576 Disease Relevance 0 Pain Relevance 0.24
In particular, disruption of Hebbian plasticity at CA1 synapses in the hippocampus appears to interfere with NMDAR-dependent memory formation.


NMDAR Binding (interfere) of in hippocampus associated with hippocampus
19) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947514 Disease Relevance 0 Pain Relevance 0.20
Here, we characterize the splicing of NMDAR1 E21.
NMDAR1 Binding (splicing) of
20) Confidence 0.18 Published 2007 Journal PLoS Biology Section Abstract Doc Link PMC1790950 Disease Relevance 0.14 Pain Relevance 0.09

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