INT112104

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Context Info
Confidence 0.44
First Reported 2003
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 21
Total Number 23
Disease Relevance 6.78
Pain Relevance 8.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grin2b) plasma membrane (Grin2b) embryo development (Grin2b)
Anatomy Link Frequency
hippocampus 2
spinal 1
nerve 1
spine 1
forebrain 1
Grin2b (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 298 100.00 Very High Very High Very High
Peripheral nerve injury 11 99.96 Very High Very High Very High
Spinal cord 19 99.84 Very High Very High Very High
long-term potentiation 346 99.48 Very High Very High Very High
allodynia 11 99.34 Very High Very High Very High
spinal dorsal horn 4 99.18 Very High Very High Very High
Neuropathic pain 15 99.08 Very High Very High Very High
Hippocampus 117 98.92 Very High Very High Very High
Opioid 10 98.32 Very High Very High Very High
neuralgia 4 98.26 Very High Very High Very High
Disease Link Frequency Relevance Heat
Immunization 12 100.00 Very High Very High Very High
Nervous System Injury 27 99.96 Very High Very High Very High
Targeted Disruption 95 99.84 Very High Very High Very High
Neuropathic Pain 26 99.34 Very High Very High Very High
Anxiety Disorder 275 99.20 Very High Very High Very High
Neurological Disease 4 98.28 Very High Very High Very High
Drug Dependence 20 98.04 Very High Very High Very High
Pain 97 93.20 High High
Congenital Anomalies 49 80.60 Quite High
Substance Withdrawal Syndrome 4 72.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Alternatively, it has been proposed that there are potential interactions for NR2A and NR2B [27], which may also account for the variability.
NR2B Binding (interactions) of
1) Confidence 0.44 Published 2007 Journal Mol Pain Section Body Doc Link PMC1871573 Disease Relevance 0.06 Pain Relevance 0.22
We report here that postsynaptic density-93 protein (PSD-93), a postsynaptic neuronal MAGUK, is expressed abundantly in spinal dorsal horn and forebrain, where it colocalizes and interacts with NMDAR subunits NR2A and NR2B.
NR2B Binding (interacts) of in forebrain associated with spinal dorsal horn
2) Confidence 0.41 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12890763 Disease Relevance 0.47 Pain Relevance 0.50
Since ifenprodil is well accepted for its selectivity on NR2B NMDARs, whereas NVP on NR2A is a debate, we therefore employed the occlusion strategy to test NR2B component with or without pretreatment with NVP.
NR2B Binding (selectivity) of
3) Confidence 0.34 Published 2007 Journal Mol Pain Section Body Doc Link PMC1871573 Disease Relevance 0 Pain Relevance 0.23
These changes in spine density were accompanied by altered expression of proteins known to interact with PSD-95, including NR2B and SAP102, suggesting that PSD-95 plays a role in regulating the expression and activation of proteins found within the NMDA receptor complex.
NR2B Binding (interact) of in spine associated with nmda receptor
4) Confidence 0.33 Published 2006 Journal Brain Res. Section Abstract Doc Link 16677619 Disease Relevance 0.07 Pain Relevance 0.28
NMDA NR2B receptor does not undergo potentiation in memory storage
NMDA NR2B Binding (receptor) of
5) Confidence 0.30 Published 2009 Journal Mol Brain Section Body Doc Link PMC2644299 Disease Relevance 0.75 Pain Relevance 0.53
Contribution of NR2B-containing NMDA receptors to synaptic LTP
NR2B-containing Binding (receptors) of associated with nmda receptor and long-term potentiation
6) Confidence 0.30 Published 2009 Journal Mol Brain Section Body Doc Link PMC2644299 Disease Relevance 0 Pain Relevance 0.75
This study demonstrated preliminary association of one variant in the GRIN2B gene encoding the N-methyl-D-aspartate (NMDA) receptor subunit 2B.
GRIN2B Binding (association) of
7) Confidence 0.28 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.58 Pain Relevance 0.30
Evidence from in vitro studies shows that PSD-93 clusters and anchors NMDARs at synapses through interaction of its PDZ domains with seven C-terminal amino acids of NR2A and NR2B [9,10].
NR2B Binding (interaction) of in synapses
8) Confidence 0.28 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 0.48 Pain Relevance 0.71
Moreover, the amount of NR2A, NR2B, and PSD-95 that co-immunoprecipitated with NR1 from crude synaptosomes was normal in Neto1-null mice, indicating that the lack of Neto1 did not alter the overall abundance of the NMDAR:PSD-95 holocomplex (Figure 6N).


NR2B Binding (amount) of
9) Confidence 0.26 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0.16 Pain Relevance 0.07
20HA co-immunoprecipitated with both NR1 and NR2B, even in the absence of PSD-95 (Figure 4A, lane 2 and 3, respectively).
NR2B Binding (immunoprecipitated) of
10) Confidence 0.26 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.04
Although Neto1 binds to both NR2A and NR2B, the loss of Neto1 leads to a reduction in the abundance of NR2A, but not NR2B, in the PSD fraction from hippocampus and a reduction in NR2A puncta in the CA1 region.
NR2B Binding (leads) of in hippocampus associated with hippocampus
11) Confidence 0.26 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.12
Other studies indicate that the cytoplasmic domains of NR2A and NR2B preferentially associate with unique sets of proteins.
NR2B Binding (associate) of
12) Confidence 0.26 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0
Despite the ability of Neto1 to bind to both NR2A and NR2B subunits in vitro, the differential effect of Neto1 on NR2A- versus NR2B-containing NMDARs in vivo, might be mediated by the extracellular, membrane or cytoplasmic domains of these NR2 subunits.
NR2B Spec (might) Binding (bind) of
13) Confidence 0.26 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0
Although Neto1 binds to both NR2A and NR2B, the loss of Neto1 leads to a reduction in the abundance of NR2A, but not NR2B, in the PSD fraction from hippocampus and a reduction in NR2A puncta in the CA1 region.
NR2B Binding (binds) of in hippocampus associated with hippocampus
14) Confidence 0.25 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.12
In parallel experiments, we did not observe the interaction between DREAM and the NMDA receptor subunits NR1, NR2A or NR2B (Figure 6B).
NR2B Neg (not) Binding (interaction) of associated with nmda receptor
15) Confidence 0.23 Published 2010 Journal Mol Brain Section Body Doc Link PMC2822766 Disease Relevance 0 Pain Relevance 0.40
These findings indicate that EphB receptor signaling, probably by interacting with NR2B in SC, contributes to the development of opioid physical dependence and withdrawal effects.
NR2B Binding (interacting) of associated with physical dependence, withdrawal, opioid and spinal cord
16) Confidence 0.22 Published 2009 Journal FASEB J. Section Abstract Doc Link 18772347 Disease Relevance 0.24 Pain Relevance 1.26
Despite the ability of Neto1 to bind to both NR2A and NR2B subunits in vitro, the differential effect of Neto1 on NR2A- versus NR2B-containing NMDARs in vivo, might be mediated by the extracellular, membrane or cytoplasmic domains of these NR2 subunits.
NR2B-containing Spec (might) Binding (bind) of
17) Confidence 0.22 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0
After blocking nonspecific protein interactions with 10% albumin in Tris-buffered saline (TBS), the nitrocellulose papers were incubated for 2 hr at room temperature with the primary antibodies: NR1 (1:1000; Pharmingen, San Diego, CA, USA), NR2A (1:1000; Zymed, San Francisco, CA, USA), NR2B (1:1000; Zymed), GluR1 (1:1500; Chemicon, Temecula, CA, USA), PSD-95 (1:2000; Affinity BioReagents, Golden, CO, USA), SAP97 (1:1000; StressGen, San Diego, CA, USA), Ca2+/calmodulin-dependent protein kinase II (?
NR2B Neg (blocking) Binding (blocking) of
18) Confidence 0.20 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1892123 Disease Relevance 0 Pain Relevance 0
These data proved the feasibility of oral immunization with rAd5/NR2B for the prevention of neuropathic pain.
NR2B Binding (immunization) of associated with immunization and neuropathic pain
19) Confidence 0.16 Published 2007 Journal Gene Ther. Section Abstract Doc Link 17960165 Disease Relevance 0.95 Pain Relevance 0.51
Prevention of neuropathic pain in an animal model of spare nerve injury following oral immunization with recombinant adenovirus serotype 5-mediated NR2B gene transfer.
NR2B Binding (immunization) of in nerve associated with neuralgia, nervous system injury, immunization and neuropathic pain
20) Confidence 0.14 Published 2007 Journal Gene Ther. Section Title Doc Link 17960165 Disease Relevance 0.87 Pain Relevance 0.63

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