INT112105

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Context Info
Confidence 0.40
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.89
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Dlg2, Grin2b) transport (Grin2b) embryo development (Grin2b)
cytoplasm (Dlg2)
Anatomy Link Frequency
cortex 3
Dlg2 (Mus musculus)
Grin2b (Mus musculus)
Pain Link Frequency Relevance Heat
Dorsal horn 12 97.92 Very High Very High Very High
spinal dorsal horn 1 96.20 Very High Very High Very High
Central nervous system 11 90.40 High High
Lasting pain 12 84.68 Quite High
Morphine 77 82.36 Quite High
nMDA receptor 5 80.92 Quite High
Peripheral nerve injury 2 78.00 Quite High
Dorsal horn neuron 1 74.24 Quite High
Acute pain 2 67.84 Quite High
withdrawal 23 66.44 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 52 100.00 Very High Very High Very High
Pain 23 84.68 Quite High
Nervous System Injury 2 77.12 Quite High
Nociception 2 70.24 Quite High
Substance Withdrawal Syndrome 4 66.80 Quite High
Drug Dependence 15 50.00 Quite Low
INFLAMMATION 2 25.76 Quite Low
Hyperalgesia 3 5.00 Very Low Very Low Very Low
Neuropathic Pain 3 5.00 Very Low Very Low Very Low
Hypersensitivity 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our quantitative Western blot analysis showed that PSD-93 deficiency significantly reduced the levels of NR2A and NR2B proteins in the synaptosomal membrane fractions of dorsal horn and forebrain cortex but did not affect their expression in the total soluble fractions of these two regions.
Negative_regulation (deficiency) of PSD-93 in cortex Negative_regulation (reduced) of Gene_expression (levels) of NR2B in cortex associated with dorsal horn
1) Confidence 0.40 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 0.41 Pain Relevance 0.64
Targeted disruption of the PSD-93 gene reduces not only surface NR2A and NR2B expression but also NMDAR-mediated excitatory postsynaptic currents and potentials, without affecting surface AMPA receptor expression or its synaptic function, in the regions mentioned above.
Negative_regulation (disruption) of PSD-93 gene Negative_regulation (reduces) of Gene_expression (expression) of NR2B associated with targeted disruption
2) Confidence 0.39 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12890763 Disease Relevance 0.49 Pain Relevance 0.57

General Comments

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