INT112109

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Context Info
Confidence 0.31
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 8.31
Pain Relevance 1.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (FIGF) extracellular space (FIGF) extracellular region (FIGF)
Anatomy Link Frequency
monocyte 2
pericytes 2
smooth muscle cells 2
heart 2
hepatocyte 1
FIGF (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 80 99.84 Very High Very High Very High
Angina 2 99.52 Very High Very High Very High
cytokine 41 96.20 Very High Very High Very High
metalloproteinase 18 94.40 High High
Kinase C 5 78.56 Quite High
Analgesic 3 78.04 Quite High
Inflammation 35 75.72 Quite High
chemokine 14 74.84 Quite High
Osteoarthritis 43 72.56 Quite High
Inflammatory response 4 57.48 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 80 99.84 Very High Very High Very High
Cv General 3 Under Development 2 99.52 Very High Very High Very High
Coronary Artery Disease 6 99.28 Very High Very High Very High
Reprotox - General 1 8 98.94 Very High Very High Very High
Ovarian Cancer 8 97.24 Very High Very High Very High
Age-related Macular Degeneration 22 95.24 Very High Very High Very High
Hyperplasia 12 94.96 High High
Hypercalcemia 12 94.84 High High
Apoptosis 118 93.88 High High
Dermal Scarring 48 91.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, pterostilbene can inhibit TPA-induced expression of vascular endothelial growth factor, epidermal growth factor and epidermal growth factor receptor.
Gene_expression (expression) of vascular endothelial growth factor
1) Confidence 0.31 Published 2009 Journal Carcinogenesis Section Abstract Doc Link 19447859 Disease Relevance 0.56 Pain Relevance 0.24
Capsaicin down-regulated the expression of the STAT3-regulated gene products, such as cyclin D1, Bcl-2, Bcl-xL, survivin, and vascular endothelial growth factor.
Gene_expression (expression) of vascular endothelial growth factor
2) Confidence 0.19 Published 2007 Journal Clin. Cancer Res. Section Body Doc Link 17505005 Disease Relevance 0.06 Pain Relevance 0
[Effect of dipyridamole on blood levels of fibroblast growth factor and vascular endothelial growth factor in patients with ischemic heart disease].
Gene_expression (levels) of vascular endothelial growth factor in heart associated with coronary artery disease
3) Confidence 0.15 Published 2003 Journal Kardiologiia Section Title Doc Link 12891306 Disease Relevance 0.20 Pain Relevance 0.09
Addition if dipyridamole to standard therapy in patients with ischemic heart disease was associated with improvement of functional class of angina and elevation of blood levels of fibroblast growth factor and Vascular Endothelial Growth Factor.
Gene_expression (levels) of Vascular Endothelial Growth Factor in heart associated with angina and coronary artery disease
4) Confidence 0.15 Published 2003 Journal Kardiologiia Section Abstract Doc Link 12891306 Disease Relevance 0.27 Pain Relevance 0.10
Lutgendorf et al. showed that elevated levels of vascular endothelial growth factor were associated with lesser degrees of social support in women with ovarian cancer [63].
Gene_expression (levels) of vascular endothelial growth factor associated with ovarian cancer
5) Confidence 0.15 Published 2009 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2723676 Disease Relevance 3.47 Pain Relevance 0.21
-induced IL-6 and vascular endothelial growth factor synthesis in RA synovial fibroblasts [41].
Gene_expression (synthesis) of vascular endothelial growth factor in fibroblasts associated with rheumatoid arthritis
6) Confidence 0.13 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888220 Disease Relevance 0.80 Pain Relevance 0.39
Remaining ovarian tissues were fixed for evaluation of morphology, expression of factor VIII (marker of endothelial cells), vascular endothelial growth factor (VEGF; expressed by pericytes and smooth muscle cells), and smooth muscle cell actin (SMCA; marker of pericytes and smooth muscle cells), and cellular proliferation and apoptosis.
Gene_expression (expressed) of vascular endothelial growth factor in pericytes associated with apoptosis and hyperplasia
7) Confidence 0.11 Published 2008 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2323016 Disease Relevance 0.33 Pain Relevance 0
Remaining ovarian tissues were fixed for evaluation of morphology, expression of factor VIII (marker of endothelial cells), vascular endothelial growth factor (VEGF; expressed by pericytes and smooth muscle cells), and smooth muscle cell actin (SMCA; marker of pericytes and smooth muscle cells), and cellular proliferation and apoptosis.
Gene_expression (expression) of vascular endothelial growth factor in pericytes associated with apoptosis and hyperplasia
8) Confidence 0.11 Published 2008 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2323016 Disease Relevance 0.33 Pain Relevance 0
The results of a recent open-label, phase II clinical trial using EGCG in prostate cancer patients showed a significant decrease in the serum levels of prostate-specific antigen, hepatocyte growth factor, and vascular endothelial growth factor after 6 weeks of treatment [55].
Gene_expression (levels) of vascular endothelial growth factor in hepatocyte associated with reprotox - general 1
9) Confidence 0.10 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888220 Disease Relevance 1.00 Pain Relevance 0.26
-actin, basic fibroblast growth factor, vascular endothelial growth factor, platelet-derived growth factor (PDGF), PDGF receptors and integrins ?
Gene_expression (receptors) of vascular endothelial growth factor in platelet
10) Confidence 0.10 Published 2010 Journal Eplasty Section Body Doc Link PMC2851107 Disease Relevance 0.62 Pain Relevance 0.15
RESULTS: Fibrinogen induced the production of interleukin 6 (IL6), interleukin 8 (IL8), monocyte chemoattractant protein-1, vascular endothelial growth factor, angiopoietin-1 and type I collagen, but not proliferation or intercellular adhesion molecule-1 expression.
Gene_expression (production) of vascular endothelial growth factor in monocyte
11) Confidence 0.08 Published 2009 Journal Gut Section Body Doc Link 19052021 Disease Relevance 0 Pain Relevance 0
RESULTS: Fibrinogen induced the production of interleukin 6 (IL6), interleukin 8 (IL8), monocyte chemoattractant protein-1, vascular endothelial growth factor, angiopoietin-1 and type I collagen, but not proliferation or intercellular adhesion molecule-1 expression.
Gene_expression (expression) of vascular endothelial growth factor in monocyte
12) Confidence 0.08 Published 2009 Journal Gut Section Body Doc Link 19052021 Disease Relevance 0 Pain Relevance 0
Remaining ovarian tissues were fixed for evaluation of morphology, expression of factor VIII (marker of endothelial cells), vascular endothelial growth factor (VEGF; expressed by pericytes and smooth muscle cells), and smooth muscle cell actin (SMCA; marker of pericytes and smooth muscle cells), and cellular proliferation and apoptosis.
Gene_expression (expression) of vascular endothelial growth factor in smooth muscle cells associated with apoptosis and hyperplasia
13) Confidence 0.04 Published 2008 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2323016 Disease Relevance 0.33 Pain Relevance 0
Remaining ovarian tissues were fixed for evaluation of morphology, expression of factor VIII (marker of endothelial cells), vascular endothelial growth factor (VEGF; expressed by pericytes and smooth muscle cells), and smooth muscle cell actin (SMCA; marker of pericytes and smooth muscle cells), and cellular proliferation and apoptosis.
Gene_expression (expressed) of vascular endothelial growth factor in smooth muscle cells associated with apoptosis and hyperplasia
14) Confidence 0.04 Published 2008 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2323016 Disease Relevance 0.33 Pain Relevance 0

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