INT112124

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 71
Total Number 71
Disease Relevance 47.82
Pain Relevance 5.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Egfr) cell morphogenesis (Egfr) Golgi apparatus (Egfr)
endoplasmic reticulum (Egfr) intracellular (Egfr) enzyme binding (Egfr)
Anatomy Link Frequency
enterocytes 4
lung 2
pancreas 1
cleavage 1
Murphy 1
Egfr (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 36 99.80 Very High Very High Very High
COX2 22 99.32 Very High Very High Very High
imagery 79 98.80 Very High Very High Very High
addiction 22 98.40 Very High Very High Very High
cINOD 62 97.96 Very High Very High Very High
antagonist 32 97.28 Very High Very High Very High
Inflammation 199 95.24 Very High Very High Very High
Inflammatory mediators 16 94.48 High High
metalloproteinase 90 91.56 High High
Kinase C 123 91.16 High High
Disease Link Frequency Relevance Heat
Cancer 1973 100.00 Very High Very High Very High
Non-small-cell Lung Cancer 334 99.96 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 375 99.86 Very High Very High Very High
Pancreatic Cancer 861 99.84 Very High Very High Very High
Bullous Skin Disease 1824 99.82 Very High Very High Very High
Lung Cancer 223 99.78 Very High Very High Very High
Breast Cancer 112 99.78 Very High Very High Very High
Solid Tumor 122 99.68 Very High Very High Very High
Acantholysis 390 99.60 Very High Very High Very High
Targeted Disruption 62 99.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Despite the current gaps in our knowledge, the evidence of EGFR overexpression in pancreatic cancer specimens, combined with convincing in vitro data demonstrating the oncogenic potential of EGFR activation, together support a role for EGFR activation in the progression of this malignancy.
Positive_regulation (activation) of EGFR associated with malignant neoplastic disease and pancreatic cancer
1) Confidence 0.70 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727779 Disease Relevance 0.89 Pain Relevance 0
At this time, the mechanism of EGFR activation in pancreatic cancer remains poorly understood.
Positive_regulation (activation) of EGFR associated with pancreatic cancer
2) Confidence 0.70 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727779 Disease Relevance 0.71 Pain Relevance 0
Despite the current gaps in our knowledge, the evidence of EGFR overexpression in pancreatic cancer specimens, combined with convincing in vitro data demonstrating the oncogenic potential of EGFR activation, together support a role for EGFR activation in the progression of this malignancy.
Positive_regulation (activation) of EGFR associated with malignant neoplastic disease and pancreatic cancer
3) Confidence 0.70 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727779 Disease Relevance 0.91 Pain Relevance 0
However, a growing number of reports had supported the idea that activation of the EGFR signal transduction pathway might induce chemo-resistance in NSCLC cells [32].
Positive_regulation (activation) of EGFR associated with non-small-cell lung cancer
4) Confidence 0.70 Published 2005 Journal Genet Vaccines Ther Section Body Doc Link PMC1187910 Disease Relevance 0.45 Pain Relevance 0
Increased activation of the EGFR-PI3K-Akt signaling pathway in tumors relative to Apc+/+ and ApcMin/+ enterocytes provides potential opportunities for therapeutic interventions to differentially suppress tumor formation, promotion, progression, and/or recurrence.
Positive_regulation (activation) of EGFR-PI3K-Akt in enterocytes associated with cancer and recurrence
5) Confidence 0.68 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15294912 Disease Relevance 1.34 Pain Relevance 0.10
Protein analyses showed that Egfr activity was highest in the tumors, and also up-regulated in Min/+ relative to WT enterocytes.
Positive_regulation (up-regulated) of Egfr in enterocytes associated with cancer
6) Confidence 0.68 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15294912 Disease Relevance 1.09 Pain Relevance 0
Apc deficiency is associated with increased Egfr activity in the intestinal enterocytes and adenomas of C57BL/6J-Min/+ mice.
Positive_regulation (increased) of Egfr in enterocytes associated with adenoma and cox2
7) Confidence 0.68 Published 2004 Journal J. Biol. Chem. Section Title Doc Link 15294912 Disease Relevance 1.02 Pain Relevance 0.05
Ligand activation of EGFR is maintained during the refractory period.
Positive_regulation (activation) of EGFR
8) Confidence 0.67 Published 2004 Journal Clin. Cancer Res. Section Body Doc Link 15355899 Disease Relevance 0.07 Pain Relevance 0
After irradiation, cells are refractory to additional transactivation of EGFR by additional irradiation for 8 to 12 hours.
Positive_regulation (transactivation) of EGFR
9) Confidence 0.67 Published 2004 Journal Clin. Cancer Res. Section Body Doc Link 15355899 Disease Relevance 0.07 Pain Relevance 0
This is consistent with previous studies that reported increased EGFR gene copy number in lung tumours [1,2].
Positive_regulation (increased) of EGFR gene in lung associated with lung cancer
10) Confidence 0.65 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2883966 Disease Relevance 0.71 Pain Relevance 0
Since activation of epidermal growth factor receptor (EGFR) promotes mechanisms leading to tumor growth and progression, EGFR-targeted agents are being widely explored.
Positive_regulation (activation) of EGFR associated with cancer
11) Confidence 0.65 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2883966 Disease Relevance 0.66 Pain Relevance 0
Since activation of epidermal growth factor receptor (EGFR) promotes mechanisms leading to tumor growth and progression, EGFR-targeted agents are being widely explored.
Positive_regulation (activation) of epidermal growth factor receptor associated with cancer
12) Confidence 0.65 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2883966 Disease Relevance 0.66 Pain Relevance 0
Prostaglandin E2 (PGE2) is a product of cyclooxygenase-2 (Cox-2) activity that is up-regulated in Min/+ tumors and transactivates Egfr.
Positive_regulation (transactivates) of Egfr in PGE2 associated with cancer
13) Confidence 0.59 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15294912 Disease Relevance 1.23 Pain Relevance 0.09
The existence of multiple ligands may confer redundancy in activation of EGFR signaling as well as enable differential signaling patterns specific to each ligand.
Positive_regulation (activation) of EGFR
14) Confidence 0.50 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727779 Disease Relevance 0.31 Pain Relevance 0.03
While the clinical focus of these agents has been on solid tumors with high levels of EGFR expression whose malignant phenotypes are known to be dependent on EGFR signaling, EGFR expression in and of itself may not be a reliable indicator of the potential antitumor activity of either class of agents, as will be discussed later.
Positive_regulation (dependent) of EGFR associated with malignant neoplastic disease and solid tumor
15) Confidence 0.50 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727779 Disease Relevance 0.36 Pain Relevance 0
EGFR overexpression with resultant increase in EGFR signaling may be associated with metastatic potential and decreased survival in patients with pancreatic cancer.
Positive_regulation (increase) of EGFR associated with pancreatic cancer
16) Confidence 0.50 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727779 Disease Relevance 0.76 Pain Relevance 0
We report here RNAi induced effective silencing of the epidermal growth factor receptor (EGFR) gene, which is over expressed in NSCLC.
Positive_regulation (induced) of EGFR associated with non-small-cell lung cancer
17) Confidence 0.50 Published 2005 Journal Genet Vaccines Ther Section Abstract Doc Link PMC1187910 Disease Relevance 1.06 Pain Relevance 0
There are indications that cell proliferation is stimulated by activation of the epidermal growth factor receptor (EGFR) (Yoshimoto et al. 2002).
Positive_regulation (activation) of EGFR
18) Confidence 0.49 Published 2007 Journal Cancer Informatics Section Body Doc Link PMC2675840 Disease Relevance 0.77 Pain Relevance 0.03
There are indications that cell proliferation is stimulated by activation of the epidermal growth factor receptor (EGFR) (Yoshimoto et al. 2002).
Positive_regulation (activation) of epidermal growth factor receptor
19) Confidence 0.49 Published 2007 Journal Cancer Informatics Section Body Doc Link PMC2675840 Disease Relevance 0.77 Pain Relevance 0.03
Increased activation of the EGFR-PI3K-Akt signaling pathway in tumors relative to Apc+/+ and ApcMin/+ enterocytes provides potential opportunities for therapeutic interventions to differentially suppress tumor formation, promotion, progression, and/or recurrence.
Positive_regulation (activation) of EGFR-PI3K-Akt in enterocytes associated with cancer and recurrence
20) Confidence 0.49 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15294912 Disease Relevance 1.34 Pain Relevance 0.10

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox