INT112144

Context Info Confidence 0.53 First Reported 2003 Last Reported 2005 Negated 0 Speculated 0 Reported most in Abstract Documents 5 Total Number 5 Disease Relevance 1.27 Pain Relevance 3.52

extracellular region (Nrg2) plasma membrane (Nrg2) embryo development (Nrg2)

Anatomy Link Frequency shell 1 brain 1 Nrg2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat gABA 5 99.94 dopamine receptor 2 99.82 antidepressant 9 99.76 Nucleus accumbens 7 99.68 Morphine 9 99.08 Clonidine 6 98.84 tricyclic antidepressant 12 97.40 antagonist 5 97.16 Neuropathic pain 2 95.96 allodynia 3 94.36

Disease Link Frequency Relevance Heat Neuropathic Pain 5 95.96 Apoptosis 1 94.40 Body Weight 12 81.76

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The region-specific downregulation of alpha1- and alpha2-adrenoceptors density, which occur after prolonged AD treatment, may underline the therapeutic mechanism of action.

Negative_regulation (downregulation) of alpha1 associated with antidepressant

1) Confidence 0.53 Published 2003 Journal Neurochem. Int. Section Abstract Doc Link 12892647 Disease Relevance 0.25 Pain Relevance 0.52

The density of hippocampal alpha1-adrenoceptors was significantly decreased only with AMI treatment (47%), without affecting the affinity for [3H]prazosin.

Negative_regulation (decreased) of alpha1

2) Confidence 0.34 Published 2003 Journal Neurochem. Int. Section Abstract Doc Link 12892647 Disease Relevance 0.32 Pain Relevance 0.56

The results suggest that chronic antidepressant (AD) treatment downregulates the cortical, but not hippocampal, alpha1- and alpha2-adrenoceptors in rat brain.

Negative_regulation (downregulates) of alpha1 in brain associated with antidepressant

3) Confidence 0.34 Published 2003 Journal Neurochem. Int. Section Abstract Doc Link 12892647 Disease Relevance 0.27 Pain Relevance 0.54

These results suggest that the functions of alpha1- and alpha2-AR in this model are excitatory and inhibitory, respectively, consistent with their general properties.

Negative_regulation (inhibitory) of alpha1

4) Confidence 0.03 Published 2005 Journal Brain Res. Section Abstract Doc Link 15781064 Disease Relevance 0.34 Pain Relevance 0.65

Caspace 1, D2 dopamine receptor, GABA-A alpha1 subunit, GRIA 1/3/4, Galphai2, PSD-95 and CREB were down-regulated in the NAc shell with morphine administration.

Negative_regulation (down-regulated) of alpha1 in shell associated with nucleus accumbens, gaba, dopamine receptor and morphine

5) Confidence 0.03 Published 2004 Journal Neuroscience Section Abstract Doc Link 15183518 Disease Relevance 0.09 Pain Relevance 1.24

General Comments

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