INT112144

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.53
First Reported 2003
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.27
Pain Relevance 3.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Nrg2) plasma membrane (Nrg2) embryo development (Nrg2)
Anatomy Link Frequency
shell 1
brain 1
Nrg2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 5 99.94 Very High Very High Very High
dopamine receptor 2 99.82 Very High Very High Very High
antidepressant 9 99.76 Very High Very High Very High
Nucleus accumbens 7 99.68 Very High Very High Very High
Morphine 9 99.08 Very High Very High Very High
Clonidine 6 98.84 Very High Very High Very High
tricyclic antidepressant 12 97.40 Very High Very High Very High
antagonist 5 97.16 Very High Very High Very High
Neuropathic pain 2 95.96 Very High Very High Very High
allodynia 3 94.36 High High
Disease Link Frequency Relevance Heat
Neuropathic Pain 5 95.96 Very High Very High Very High
Apoptosis 1 94.40 High High
Body Weight 12 81.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The region-specific downregulation of alpha1- and alpha2-adrenoceptors density, which occur after prolonged AD treatment, may underline the therapeutic mechanism of action.
Negative_regulation (downregulation) of alpha1 associated with antidepressant
1) Confidence 0.53 Published 2003 Journal Neurochem. Int. Section Abstract Doc Link 12892647 Disease Relevance 0.25 Pain Relevance 0.52
The density of hippocampal alpha1-adrenoceptors was significantly decreased only with AMI treatment (47%), without affecting the affinity for [3H]prazosin.
Negative_regulation (decreased) of alpha1
2) Confidence 0.34 Published 2003 Journal Neurochem. Int. Section Abstract Doc Link 12892647 Disease Relevance 0.32 Pain Relevance 0.56
The results suggest that chronic antidepressant (AD) treatment downregulates the cortical, but not hippocampal, alpha1- and alpha2-adrenoceptors in rat brain.
Negative_regulation (downregulates) of alpha1 in brain associated with antidepressant
3) Confidence 0.34 Published 2003 Journal Neurochem. Int. Section Abstract Doc Link 12892647 Disease Relevance 0.27 Pain Relevance 0.54
These results suggest that the functions of alpha1- and alpha2-AR in this model are excitatory and inhibitory, respectively, consistent with their general properties.
Negative_regulation (inhibitory) of alpha1
4) Confidence 0.03 Published 2005 Journal Brain Res. Section Abstract Doc Link 15781064 Disease Relevance 0.34 Pain Relevance 0.65
Caspace 1, D2 dopamine receptor, GABA-A alpha1 subunit, GRIA 1/3/4, Galphai2, PSD-95 and CREB were down-regulated in the NAc shell with morphine administration.
Negative_regulation (down-regulated) of alpha1 in shell associated with nucleus accumbens, gaba, dopamine receptor and morphine
5) Confidence 0.03 Published 2004 Journal Neuroscience Section Abstract Doc Link 15183518 Disease Relevance 0.09 Pain Relevance 1.24

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox