INT112147

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Context Info
Confidence 0.49
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 3.42
Pain Relevance 2.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1b) aging (Il1b) extracellular region (Il1b)
Anatomy Link Frequency
blood 2
spinal cord 2
neurons 2
brain 2
Il1b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
trigeminal ganglion 8 100.00 Very High Very High Very High
Intracerebroventricular 4 100.00 Very High Very High Very High
Neuronal excitability 1 99.96 Very High Very High Very High
Spinal cord 2 99.92 Very High Very High Very High
Inflammation 10 97.68 Very High Very High Very High
Hyperalgesia 9 97.66 Very High Very High Very High
Neuropathic pain 2 94.96 High High
Sciatic nerve 4 94.80 High High
ischemia 8 93.72 High High
qutenza 2 89.36 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 9 100.00 Very High Very High Very High
Pancreatitis 6 99.96 Very High Very High Very High
INFLAMMATION 8 97.68 Very High Very High Very High
Hyperalgesia 10 97.66 Very High Very High Very High
Nervous System Injury 1 95.08 Very High Very High Very High
Cv Unclassified Under Development 8 93.72 High High
Aids-related Complex 3 85.92 High High
Injury 8 83.52 Quite High
Peripheral Arterial Disease 1 63.04 Quite High
Neuropathic Pain 2 55.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To identify the part of the brain that is affected by hyperalgesia-induced IL-1beta and the possible site of alpha-MSH inhibition, we have examined Fos expression in the rat brain in response to ICV microinjection of alpha-MSH and/or IL-1beta.
Spec (examined) Positive_regulation (response) of Negative_regulation (microinjection) of IL-1beta in brain associated with hyperalgesia and intracerebroventricular
1) Confidence 0.49 Published 2005 Journal Neuroendocrinology Section Abstract Doc Link 16015027 Disease Relevance 0.56 Pain Relevance 0.59
These results indicate that the protective effect by ghrelin in the spinal cord is mediated through the suppression of TNF-alpha and IL-1beta.
Positive_regulation (mediated) of Negative_regulation (suppression) of IL-1beta in spinal cord associated with spinal cord
2) Confidence 0.49 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20561937 Disease Relevance 0.81 Pain Relevance 0.96
Ischemic preconditioning, applied prior to induction of pancreatitis, caused the reduction in plasma lipase, plasma interleukin-1beta and histological signs of pancreatic damage, as well as attenuated the reduction in pancreatic blood flow and DNA synthesis.
Positive_regulation (caused) of Negative_regulation (reduction) of interleukin-1beta in blood associated with pancreatitis
3) Confidence 0.45 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12892840 Disease Relevance 0.94 Pain Relevance 0.44
These results suggest that the inhibitory effect of I(A) and I(K) currents by IL-1beta in small-diameter TRG neurons potentiates neuronal excitability thereby contributing to trigeminal inflammatory hyperalgesia.
Positive_regulation (potentiates) of Negative_regulation (effect) of IL-1beta in neurons associated with hyperalgesia, inflammation, neuronal excitability and trigeminal ganglion
4) Confidence 0.17 Published 2008 Journal Pain Section Abstract Doc Link 18694623 Disease Relevance 1.11 Pain Relevance 0.78

General Comments

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