INT112166

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Context Info
Confidence 0.72
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 15
Total Number 16
Disease Relevance 8.86
Pain Relevance 2.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gast)
Anatomy Link Frequency
parietal cell 1
Gast (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 20 99.56 Very High Very High Very High
Potency 2 99.28 Very High Very High Very High
Somatostatin 54 98.52 Very High Very High Very High
antagonist 21 96.80 Very High Very High Very High
Inflammation 4 96.60 Very High Very High Very High
anesthesia 11 96.00 Very High Very High Very High
halothane 38 92.80 High High
peptic ulcer disease 3 90.08 High High
isoflurane 38 76.88 Quite High
adenocard 1 69.20 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 66 99.86 Very High Very High Very High
Cancer 94 99.44 Very High Very High Very High
Metastasis 30 97.04 Very High Very High Very High
INFLAMMATION 3 96.60 Very High Very High Very High
Stomach Cancer 2 95.96 Very High Very High Very High
Fistula 5 94.52 High High
Gastritis 2 94.52 High High
Frailty 8 91.68 High High
Carcinoid 47 90.72 High High
Gastric Fistula 2 89.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, in HDC-/- mice, theophylline failed to exert an effect on basal acid secretion, as well as carbachol- and gastrin-stimulated acid secretion.
Localization (secretion) of gastrin-stimulated
1) Confidence 0.72 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12893847 Disease Relevance 0.19 Pain Relevance 0.10
The present work investigated the role of endogenous histamine in carbachol- and gastrin-induced gastric acid secretion with HDC-knockout (HDC-/-) mice.
Localization (secretion) of gastrin associated with targeted disruption
2) Confidence 0.72 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12893847 Disease Relevance 0.27 Pain Relevance 0.09
In wild-type mice, theophylline significantly increased acid secretion, enhancing carbachol- and gastrin-stimulated acid secretion.
Localization (secretion) of gastrin-stimulated
3) Confidence 0.72 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12893847 Disease Relevance 0.21 Pain Relevance 0.11
Such results suggest that 1) histamine is essential for carbachol- and gastrin-stimulated gastric acid secretion in mice; and 2) histamine-induced cAMP production contributes to the in vivo response to carbachol or gastrin.
Localization (secretion) of gastrin-stimulated
4) Confidence 0.72 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12893847 Disease Relevance 0.13 Pain Relevance 0.09
We conclude that G-gly synergizes with amidated gastrin to stimulate acid secretion and inhibits parietal cell loss in INS-GAS/G-gly mice.
Localization (secretion) of gastrin in parietal cell
5) Confidence 0.71 Published 2004 Journal Cancer Res. Section Abstract Doc Link 15548680 Disease Relevance 0.70 Pain Relevance 0.09
Recently we have reported synergistic effects between glycine-extended gastrin (G-gly) and amidated gastrin-17 on acid secretion in short-term infusion studies.
Localization (secretion) of gastrin-17
6) Confidence 0.71 Published 2004 Journal Cancer Res. Section Abstract Doc Link 15548680 Disease Relevance 0.46 Pain Relevance 0
Unexpectedly, M(1) KO mice exhibited normal intragastric pH, serum gastrin and mucosal histamine levels, and gastric acid secretion stimulated by carbachol, histamine, and gastrin.
Localization (secretion) of gastrin associated with targeted disruption
7) Confidence 0.69 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15691866 Disease Relevance 0.61 Pain Relevance 0.14
Unexpectedly, M(1) KO mice exhibited normal intragastric pH, serum gastrin and mucosal histamine levels, and gastric acid secretion stimulated by carbachol, histamine, and gastrin.
Localization (secretion) of gastrin associated with targeted disruption
8) Confidence 0.69 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15691866 Disease Relevance 0.61 Pain Relevance 0.14
In wild-type mice, somatostatin-14, SMS 201-995, and the SSTR2-preferential agonist, DC 32-87, inhibited gastrin-stimulated acid secretion with an order of potency SMS 201-995>DC 32-87>somatostatin-14.
Localization (secretion) of gastrin associated with agonist, somatostatin and potency
9) Confidence 0.66 Published 2004 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 15599710 Disease Relevance 0.67 Pain Relevance 0.72
In wild-type mice, carbachol and gastrin significantly stimulated acid secretion, increasing gastric mucosal histamine.
Localization (secretion) of gastrin
10) Confidence 0.63 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12893847 Disease Relevance 0.26 Pain Relevance 0.13
In SSTR2 knockout mice, gastrin and histamine stimulated acid secretion with similar efficacy, while in wild-type mice histamine was more effective than gastrin.
Localization (secretion) of gastrin associated with targeted disruption
11) Confidence 0.58 Published 2004 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 15599710 Disease Relevance 0.66 Pain Relevance 0.58
Barbiturates were first synthesized in 1864, but their value as GAs was not recognized until 1903.
Localization (value) of GAs
12) Confidence 0.21 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989583 Disease Relevance 0.25 Pain Relevance 0.14
In the subsequent 50 years or so, experimental data on the efficacy of various chemicals, especially homologous organic series, as GAs, accumulated.
Localization (accumulated) of GAs
13) Confidence 0.21 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989583 Disease Relevance 0 Pain Relevance 0.03
Immunochemistry of the GHRH-secreting tumors has regularly demonstrated cosecretion of other hormones, including gastrin, gastrin-releasing peptide, calcitonin, pancreatic polypeptide, VIP, glucagon, insulin, and somatostatin, pointing to the multihormonal nature of these tumors.
Localization (cosecretion) of gastrin associated with cancer and somatostatin
14) Confidence 0.17 Published 2007 Journal Pituitary Section Body Doc Link PMC2045692 Disease Relevance 1.56 Pain Relevance 0.15
Immunochemistry of the GHRH-secreting tumors has regularly demonstrated cosecretion of other hormones, including gastrin, gastrin-releasing peptide, calcitonin, pancreatic polypeptide, VIP, glucagon, insulin, and somatostatin, pointing to the multihormonal nature of these tumors.
Localization (cosecretion) of gastrin associated with cancer and somatostatin
15) Confidence 0.17 Published 2007 Journal Pituitary Section Body Doc Link PMC2045692 Disease Relevance 1.56 Pain Relevance 0.15
Since PPIs produce histamine, gastrin or acetylcholine-independent inhibition of acid secretion, they provide more sustained increase of the gastric pH than H2-receptor (H2R) antagonists [5].
Localization (secretion) of gastrin associated with antagonist
16) Confidence 0.11 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2386521 Disease Relevance 0.71 Pain Relevance 0.25

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