INT112174

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Context Info
Confidence 0.78
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 47
Total Number 82
Disease Relevance 26.26
Pain Relevance 20.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Trpv4) cilium (Trpv4) transmembrane transport (Trpv4)
Anatomy Link Frequency
dorsal root ganglion 8
F11 7
neurons 5
neurite 2
growth cone 2
Trpv4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 753 100.00 Very High Very High Very High
Hyperalgesia 161 100.00 Very High Very High Very High
TRP channel 145 100.00 Very High Very High Very High
nociceptor 61 100.00 Very High Very High Very High
5HT 20 100.00 Very High Very High Very High
Serotonin 11 100.00 Very High Very High Very High
Taxol 1087 99.98 Very High Very High Very High
imagery 451 99.92 Very High Very High Very High
Pain 538 99.84 Very High Very High Very High
qutenza 123 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 827 100.00 Very High Very High Very High
Hyperalgesia 164 100.00 Very High Very High Very High
Nociception 561 99.84 Very High Very High Very High
Pain 498 99.84 Very High Very High Very High
Overactive Bladder 19 99.78 Very High Very High Very High
Neuropathic Pain 256 99.36 Very High Very High Very High
Stress 62 99.12 Very High Very High Very High
Shock 72 98.72 Very High Very High Very High
Increased Venous Pressure Under Development 72 97.32 Very High Very High Very High
Stress Incontinence 8 96.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Antisense-induced decrease in expression of TRPV4 confirmed that the channel is required for hypotonic stimulus-induced nociception.
Gene_expression (expression) of TRPV4 associated with nociception
1) Confidence 0.78 Published 2003 Journal Neuron Section Abstract Doc Link 12895423 Disease Relevance 0.79 Pain Relevance 0.34
Collateral Trpv4 expression was quantified by reverse transcription-polymerase chain reaction.
Gene_expression (expression) of Trpv4
2) Confidence 0.78 Published 2010 Journal Eur J Vasc Endovasc Surg Section Body Doc Link 20304685 Disease Relevance 0 Pain Relevance 0
Trpv4 expression in collaterals harvested 0.5h post exercise was not significantly different from expression in shunted rats.
Gene_expression (expression) of Trpv4
3) Confidence 0.78 Published 2010 Journal Eur J Vasc Endovasc Surg Section Body Doc Link 20304685 Disease Relevance 0 Pain Relevance 0
First, the levels of TRPV4 mRNA and protein expression in the dorsal root ganglion (DRG) were assessed using real-time RT-PCR and Western blotting analysis respectively at 7, 14, and 28 days post-CCD.
Gene_expression (levels) of TRPV4 mRNA in dorsal root ganglion associated with ganglion cysts and dorsal root ganglion
4) Confidence 0.78 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18206306 Disease Relevance 0.95 Pain Relevance 0.60
Here, we demonstrate expression of functional TRPV4 protein in the urothelium lining the renal pelvis, ureters, urinary bladder, and urethra.
Gene_expression (expression) of TRPV4 in urinary bladder associated with stress incontinence
5) Confidence 0.78 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17636010 Disease Relevance 0.16 Pain Relevance 0.04
Trpv4 expression as well as Ki67-positive staining was significantly increased in collateral vessels.
Gene_expression (expression) of Trpv4 in vessels
6) Confidence 0.78 Published 2009 Journal J. Cell. Mol. Med. Section Abstract Doc Link 19017361 Disease Relevance 0.48 Pain Relevance 0.06
Cultured porcine endothelial cells showed a dose-dependent expression of Trpv4 and an increased level of Ki67-positive cells upon treatment with 4alpha-Phorbol 12,13-didecanoate (4alphaPDD), a specific Trpv4 activator.
Gene_expression (expression) of Trpv4 in endothelial cells
7) Confidence 0.78 Published 2009 Journal J. Cell. Mol. Med. Section Abstract Doc Link 19017361 Disease Relevance 0.41 Pain Relevance 0.08
An increased protein expression of Trpv4 was localized in the FSS-sensing endothelium by means of confocal immunohistochemistry.
Gene_expression (expression) of Trpv4 in endothelium associated with stress
8) Confidence 0.78 Published 2009 Journal J. Cell. Mol. Med. Section Abstract Doc Link 19017361 Disease Relevance 0.45 Pain Relevance 0.08
Spinal administration of antisense oligodeoxynucleotides to TRPV4, which reduced the expression of TRPV4 in sensory nerve, abolished Taxol-induced mechanical hyperalgesia and attenuated hypotonic hyperalgesia by 42%.
Gene_expression (expression) of TRPV4 in sensory nerve associated with hyperalgesia and taxol
9) Confidence 0.78 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15128858 Disease Relevance 1.07 Pain Relevance 1.37
We studied the function of TRPV4 expression and its neuronal activation in response to noxious stimulation of oral mucosa.
Gene_expression (expression) of TRPV4 in oral mucosa
10) Confidence 0.77 Published 2009 Journal Okajimas Folia Anat Jpn Section Abstract Doc Link 19877445 Disease Relevance 0.21 Pain Relevance 0.15
Expression of TRPV4 in the stimulated rat oral mucous membrane--nociceptive mechanisms of lingual conical papillae.
Gene_expression (Expression) of TRPV4 in papillae associated with nociception and nociceptor
11) Confidence 0.77 Published 2009 Journal Okajimas Folia Anat Jpn Section Title Doc Link 19877445 Disease Relevance 0.24 Pain Relevance 0.37
Immunohistological studies of the TRPV4, pERK and serotonin (5HT) expression in designated regions of tongues and brainstems were performed for studying the descending pain modulatory system in response to nociception.
Gene_expression (expression) of TRPV4 in brainstems associated with nociception, pain, 5ht and serotonin
12) Confidence 0.77 Published 2009 Journal Okajimas Folia Anat Jpn Section Abstract Doc Link 19877445 Disease Relevance 0.27 Pain Relevance 0.22
Real-time reverse transcription polymerase chain reaction and Western blot analysis were performed to assess the change of TRPV4 messenger RNA (mRNA) and protein expression in DRG.
Gene_expression (expression) of TRPV4 in DRG
13) Confidence 0.77 Published 2010 Journal Neurol. Res. Section Body Doc Link 19278577 Disease Relevance 0.17 Pain Relevance 0
The present study intended to evaluate the effect of small interfering RNA (siRNA) on the expression and function of TRPV4 in DRG neurons and its possible usage in pain relief treatment.
Gene_expression (expression) of TRPV4 in neurons associated with pain and dorsal root ganglion
14) Confidence 0.77 Published 2010 Journal Neurol. Res. Section Abstract Doc Link 19278577 Disease Relevance 0.65 Pain Relevance 0.42
TRPV4 protein expression was also decreased significantly, as indicated by Western blot.
Gene_expression (expression) of TRPV4 protein
15) Confidence 0.77 Published 2010 Journal Neurol. Res. Section Body Doc Link 19278577 Disease Relevance 0.13 Pain Relevance 0
Inhibition of the expression and function of TRPV4 by RNA interference in dorsal root ganglion.
Gene_expression (expression) of TRPV4 in dorsal root ganglion associated with ganglion cysts and dorsal root ganglion
16) Confidence 0.77 Published 2010 Journal Neurol. Res. Section Title Doc Link 19278577 Disease Relevance 0.47 Pain Relevance 0.41
At last, immunohistochemistry stainings were performed to observe expression of TRPV4/CGRP/MaxiK in mesenteric resistance arteries and sensory neurons/nerve fibers.
Gene_expression (expression) of TRPV4 in nerve
17) Confidence 0.76 Published 2010 Journal J. Hypertens. Section Body Doc Link 19996988 Disease Relevance 0 Pain Relevance 0
Previously we have shown that the transient receptor potential vanilloid 4 (TRPV4) channel regulates urinary bladder function, and that TRPV4 is expressed in both smooth muscle and urothelial cell types within the bladder wall.(1) Urothelial cells have also been suggested to express TRPV1 channels.(2) Therefore, we enzymatically isolated guinea-pig urothelial cells in an attempt to record TRPV4 and TRPV1-mediated currents.
Gene_expression (expressed) of TRPV4 in urothelial cells associated with overactive bladder
18) Confidence 0.76 Published 2009 Journal Channels (Austin) Section Abstract Doc Link 19411839 Disease Relevance 0.10 Pain Relevance 0.11
We demonstrate that TRPV4 channels are functionally expressed at the plasma membrane of freshly isolated, guinea-pig urothelial cells, further supporting the important role of TRPV4 in urinary bladder physiology.
Gene_expression (expressed) of TRPV4 in urothelial cells
19) Confidence 0.76 Published 2009 Journal Channels (Austin) Section Abstract Doc Link 19411839 Disease Relevance 0.06 Pain Relevance 0.26
MBP-LacZ and MBP-TRPV4-Ct constructs were expressed in E. coli; the cleared cell lysates were applied to amylose resin (NEB), and incubated for 1 hour at RT (25°C) followed by washing.
Gene_expression (expressed) of TRPV4
20) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0.15 Pain Relevance 0

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