INT112175

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Context Info
Confidence 0.59
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 3.70
Pain Relevance 3.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Trpv4) cilium (Trpv4) transmembrane transport (Trpv4)
Anatomy Link Frequency
dorsal root ganglion 6
sensory nerve 2
Trpv4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 1 99.84 Very High Very High Very High
dorsal root ganglion 42 99.44 Very High Very High Very High
Taxol 37 98.84 Very High Very High Very High
Pain 32 98.52 Very High Very High Very High
Hyperalgesia 8 97.84 Very High Very High Very High
allodynia 6 96.52 Very High Very High Very High
Calcium channel 3 96.20 Very High Very High Very High
Inflammation 19 92.08 High High
peripheral neuropathy 4 91.48 High High
c fibre 1 89.96 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 42 99.44 Very High Very High Very High
Pain 30 98.52 Very High Very High Very High
Hyperalgesia 9 97.84 Very High Very High Very High
Nociception 31 97.16 Very High Very High Very High
Neuropathic Pain 38 96.52 Very High Very High Very High
INFLAMMATION 20 92.08 High High
Peripheral Neuropathy 4 91.48 High High
Myelodysplastic Syndromes 1 90.32 High High
Cancer 4 86.36 High High
Inflammatory Pain 13 76.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Antisense-induced decrease in expression of TRPV4 confirmed that the channel is required for hypotonic stimulus-induced nociception.
Negative_regulation (decrease) of Gene_expression (expression) of TRPV4 associated with nociception
1) Confidence 0.59 Published 2003 Journal Neuron Section Abstract Doc Link 12895423 Disease Relevance 0.80 Pain Relevance 0.34
Inhibition of the expression and function of TRPV4 by RNA interference in dorsal root ganglion.
Negative_regulation (Inhibition) of Gene_expression (expression) of TRPV4 in dorsal root ganglion associated with ganglion cysts and dorsal root ganglion
2) Confidence 0.58 Published 2010 Journal Neurol. Res. Section Title Doc Link 19278577 Disease Relevance 0.47 Pain Relevance 0.41
TRPV4 protein expression was also decreased significantly, as indicated by Western blot.
Negative_regulation (decreased) of Gene_expression (expression) of TRPV4 protein
3) Confidence 0.58 Published 2010 Journal Neurol. Res. Section Body Doc Link 19278577 Disease Relevance 0.13 Pain Relevance 0
First, the levels of TRPV4 mRNA and protein expression in the dorsal root ganglion (DRG) were assessed using real-time RT-PCR and Western blotting analysis respectively at 7, 14, and 28 days post-CCD.
Negative_regulation (levels) of Gene_expression (levels) of TRPV4 mRNA in dorsal root ganglion associated with ganglion cysts and dorsal root ganglion
4) Confidence 0.43 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18206306 Disease Relevance 0.95 Pain Relevance 0.60
Spinal administration of antisense oligodeoxynucleotides to TRPV4, which reduced the expression of TRPV4 in sensory nerve, abolished Taxol-induced mechanical hyperalgesia and attenuated hypotonic hyperalgesia by 42%.
Negative_regulation (reduced) of Gene_expression (expression) of TRPV4 in sensory nerve associated with hyperalgesia and taxol
5) Confidence 0.43 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15128858 Disease Relevance 1.07 Pain Relevance 1.37
CONCLUSION: TRPV4 is a key component in hypotonic signal transduction, and designed siRNA inhibits mRNA level, protein expression and function of TRPV4 in DRG neurons.
Negative_regulation (designed) of Gene_expression (expression) of TRPV4 in DRG
6) Confidence 0.42 Published 2010 Journal Neurol. Res. Section Body Doc Link 19278577 Disease Relevance 0 Pain Relevance 0
In contrast, cells, which did not express TRPV4 were unaffected by 4?
Neg (unaffected) Negative_regulation (unaffected) of Neg (not) Gene_expression (express) of TRPV4
7) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0 Pain Relevance 0.10
Previous reports demonstrated that HC-030031 does not block TRPV1, TRPV3 or TRPV4 activation by capsaicin, 2-APB, and 4?
Negative_regulation (block) of Gene_expression (activation) of TRPV4 associated with qutenza
8) Confidence 0.23 Published 2008 Journal Mol Pain Section Body Doc Link PMC2584039 Disease Relevance 0.28 Pain Relevance 0.30

General Comments

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